CAS No.11003-38-6,Capreomycin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	11003-38-6
Name:	Capreomycin

Formula:	C50H88N28O15
Molecular Weight:	1321.41232
Synonyms:	Capastat;Capostatin; Capreomicin; Capromycin
Boiling Point:	1376.7°C at 760 mmHg
Flash Point:	786.4°C
Safety:	A poison by intravenous route. Moderately toxic by subcutaneous route. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

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Chemistry

Chemistry informtion about Capreomycin (CAS NO.11003-38-6) is:
IUPAC Name: 3,6-diamino-N-[[(4Z)-11-amino-7-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-4-[(carbamoylamino)methylidene]-14-(hydroxymethyl)-2,5,8,12,15-pentaoxo-3,6,9,13,16-pentazacyclohexadec-1-yl]methyl]hexanamide; sulfuric acid
Synonyms: 3,6-Diamino-N-[[(8z)-15-Amino-11-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-2-(Hydroxymethyl)-3,6,9,12,16-Pentaoxo-8-(Ureidomethylene)-1,4,7,10,13-Pentazacyclohexadec-5-Yl]Methyl]Hexanamide ; Sulfuric Acid
MF: C₂₅H₄₆N₁₄O₁₂S
MW: 766.7843
Flash Point: 786.4 °C
Boiling Point: 1376.7 °C at 760 mmHg
Enthalpy of Vaporization: 234.62 kJ/mol
Following is the molecular structure of Capreomycin (CAS NO.11003-38-6) is:

Production

Raw materials: Cation exchange resin,strong acidic styrene --> Cation exchange resin,weak acidic acrylic acid

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	1371mg/kg/96D (1371mg/kg)	vascular: bp elevation not characterized in autonomic section	American Journal of Kidney Diseases. Vol. 7, Pg. 245, 1986.
mouse	LD50	intravenous	238mg/kg (238mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 353, 1974.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 861, 1967.
mouse	LD50	subcutaneous	514mg/kg (514mg/kg)		Yakkyoku. Pharmacy. Vol. 25, Pg. 353, 1974.

Safety Profile

A poison by intravenous route. Moderately toxic by subcutaneous route. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Specification

Capreomycin (CAS NO.11003-38-6) is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for tuberculosis. Adverse effects include nephrotoxicity and 8th cranial nerve toxicity.The drug should not be given with streptomycin or other drugs that may damage the 8th nerve.