CAS No.1104-22-9,Meclizine dihydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1104-22-9
Name:	Meclizine dihydrochloride
Article Data:	1

Formula:	C₂₅H₂₉Cl₃N₂
Molecular Weight:	463.878
Synonyms:	Piperazine,1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride (6CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride(9CI);1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride;Ancolandihydrochloride;Bonamine;Diadril;Meclizine dihydrochloride;Meclizinehydrochloride;Meclozine dihydrochloride;Meclozine hydrochloride;NSC 28728;Navidoxine;Parachloramine dihydrochloride;Postafen;Postafene dihydrochloride;
EINECS:	214-164-8
Density:	1.159g/cm3
Melting Point:	210.0 to 214.0 °C
Boiling Point:	495.3 °C at 760 mmHg
Flash Point:	253.3 °C
Appearance:	white,slightly yellowish,crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22-63
Safety:	22-36
PSA:	6.48000
LogP:	7.03540

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Chemistry

IUPAC: 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride
The molecular structure of Meclozine dihydrochloride (CAS NO.1104-22-9):

Molecular Formula: C₂₅H₂₉Cl₃N₂
Molecular Weight: 463.87
EINECS: 214-164-8
LogP: ACD/LogP: 4.99
ACD/LogD (pH 5.5): 3.86
ACD/LogD (pH 7.4): 4.93
ACD/BCF (pH 5.5): 270.77
ACD/BCF (pH 7.4): 3158.05
ACD/KOC (pH 5.5): 915.03
ACD/KOC (pH 7.4): 10672.26
Covalently-Bonded Unit Count: 3
Flash Point: 253.3°C
Storage temp.: 2-8 °C
Enthalpy of Vaporization: 76.28 kJ/mol
Boiling Point: 495.3°C at 760 mmHg
Vapour Pressure: 6E-10 mmHg at 25 °C
The appearance of Meclozine dihydrochloride (CAS NO.1104-22-9): white,slightly yellowish,crystalline powder
Canonical SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
InChI: InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
InChIKey: VCTHNOIYJIXQLV-UHFFFAOYSA-N

Uses

Meclozine dihydrochloride (CAS NO.1104-22-9) is used as antiemetic, histamine H1 antagonist and anti-allergic agent.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	625mg/kg (625mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.
mouse	LD50	oral	1600mg/kg (1600mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 67, 1969.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.
Hazard Codes: Harmful Xn
Risk Statements: 22-63
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child.
Safety Statements: 22-36
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: TL2005000

Specification

Meclozine dihydrochloride (CAS NO.1104-22-9) is also called for 1-p-Chlorbenzhydryl-m-methylbenzylpiperazine dihydrochloride ; Ancolan dihydrochloride ; Antivert ; Bonamine ; Diadril ; Duremesin ; EINECS 214-164-8 ; Meclizine HCl ; Meclizine dihydrochloride ; NSC 28728 ; Parachloramine dihydrochloride ; Postafen ; Postafene dihydrochloride ; Taizer ; UNII-L997QXC9J1 ; V-Cline ; Vertizine and so on. Its classification code are Drug / Therapeutic Agent and Reproductive Effect.