CAS No.11041-12-6,CHOLESTYRAMINE RESIN Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	11041-12-6
Name:	CHOLESTYRAMINE RESIN

Formula:	Unspecified
Molecular Weight:	385.66878
Synonyms:	Cholestyraminechloride;Cholestyramine hydroxide;Cholestyramine resin;Cholybar;Colestyramin;Cuemid;LoCholest;Quantalan;Questran Light;
EINECS:	234-270-8
Hazard Symbols:	Xi
Safety:	22-24/25
PSA:	0.00000
LogP:	2.54390

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The Cholestyramine with cas registry number of 11041-12-6 also has other registry numbers including 58391-37-0 and 9007-26-5. Its EINECS registry number is 234-270-8. Its molecular formula has not been unspecified. And no descriptors have found for this chemical. It is white to buff-colored fine powder with odorless or a slight amine odor. It is insoluble in water.

This chemical belongs to classification codes which include (1)Anion exchange resins; (2)Anticholesteremic agents; (3)Antihyperlipidemic; (4)Antilipemic Agents; (5)Antimetabolites; (6)Human Data; (7)Ion Exchange Resins; (8)Ion-exchange resin [bile salts]; (9)Reproductive Effect; (10)Tumor data. It is also known as (1)HSDB 7219; (2)Locholest; (3)Locholest Light; (4)Polystyrene benzyltrimethylaminonium chloride; (5)Prevalite; (6)Quantalan; (7)Questran; (8)Questran Light; (9)UNII-4B33BGI082.

Uses of Cholestyramine: this compound has been used as a drug for the treatment of typeⅡhyperlipidemia, atherosclerosis and Itching caused by Cirrhosis and gallstone disease. There is a disadvantage about this drug. It has to be used in a large amount during the treatment. About 2% of patients have the gastrointestinal tract.

When you are using this chemical, please be cautious about it as the following:
Low toxicity by ingestion. Questionable human carcinogen producing colon tumors. An experimental teratogen. Other experimental reproductive effects. Toxic effects by ingestion: acidosis and nosebleeds. When heated to decomposition it emits acrid smoke and irritating fumes.

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	46gm/kg/39W-I (46000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BLOOD: HEMORRHAGE	Canadian Medical Association Journal. Vol. 134, Pg. 609, 1986.
infant	TDLo	oral	4gm/kg/2D-I (4000mg/kg)		American Journal of Diseases of Children. Vol. 141, Pg. 479, 1987.
infant	TDLo	unreported	42gm/kg/7W-I (42000mg/kg)	BLOOD: EOSINOPHILIA	Clinical Pediatrics Vol. 20, Pg. 675, 1981.
mouse	LD50	intraperitoneal	> 4gm/kg (4000mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.
mouse	LD50	oral	> 7500mg/kg (7500mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.
mouse	LD50	subcutaneous	> 3gm/kg (3000mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.
rabbit	LD50	oral	> 3gm/kg (3000mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.
rat	LD50	intraperitoneal	> 1600mg/kg (1600mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.
rat	LD50	oral	> 4gm/kg (4000mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.
rat	LD50	subcutaneous	> 1200mg/kg (1200mg/kg)		Drugs in Japan Vol. -, Pg. 412, 1990.