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| CAS No.: | 11041-12-6 |
|---|---|
| Name: | CHOLESTYRAMINE RESIN |
| Molecular Structure: | |
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| Formula: | Unspecified |
| Molecular Weight: | 385.66878 |
| Synonyms: | Cholestyraminechloride;Cholestyramine hydroxide;Cholestyramine resin;Cholybar;Colestyramin;Cuemid;LoCholest;Quantalan;Questran Light; |
| EINECS: | 234-270-8 |
| Hazard Symbols: | Xi |
| Safety: | 22-24/25 |
| PSA: | 0.00000 |
| LogP: | 2.54390 |
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Consensus Reports
Reported in EPA TSCA Inventory.
Specification
The Cholestyramine with cas registry number of 11041-12-6 also has other registry numbers including 58391-37-0 and 9007-26-5. Its EINECS registry number is 234-270-8. Its molecular formula has not been unspecified. And no descriptors have found for this chemical. It is white to buff-colored fine powder with odorless or a slight amine odor. It is insoluble in water.
This chemical belongs to classification codes which include (1)Anion exchange resins; (2)Anticholesteremic agents; (3)Antihyperlipidemic; (4)Antilipemic Agents; (5)Antimetabolites; (6)Human Data; (7)Ion Exchange Resins; (8)Ion-exchange resin [bile salts]; (9)Reproductive Effect; (10)Tumor data. It is also known as (1)HSDB 7219; (2)Locholest; (3)Locholest Light; (4)Polystyrene benzyltrimethylaminonium chloride; (5)Prevalite; (6)Quantalan; (7)Questran; (8)Questran Light; (9)UNII-4B33BGI082.
Uses of Cholestyramine: this compound has been used as a drug for the treatment of typeⅡhyperlipidemia, atherosclerosis and Itching caused by Cirrhosis and gallstone disease. There is a disadvantage about this drug. It has to be used in a large amount during the treatment. About 2% of patients have the gastrointestinal tract.
When you are using this chemical, please be cautious about it as the following:
Low toxicity by ingestion. Questionable human carcinogen producing colon tumors. An experimental teratogen. Other experimental reproductive effects. Toxic effects by ingestion: acidosis and nosebleeds. When heated to decomposition it emits acrid smoke and irritating fumes.
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 46gm/kg/39W-I (46000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BLOOD: HEMORRHAGE | Canadian Medical Association Journal. Vol. 134, Pg. 609, 1986. |
| infant | TDLo | oral | 4gm/kg/2D-I (4000mg/kg) | American Journal of Diseases of Children. Vol. 141, Pg. 479, 1987. | |
| infant | TDLo | unreported | 42gm/kg/7W-I (42000mg/kg) | BLOOD: EOSINOPHILIA | Clinical Pediatrics Vol. 20, Pg. 675, 1981. |
| mouse | LD50 | intraperitoneal | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. | |
| mouse | LD50 | oral | > 7500mg/kg (7500mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. | |
| mouse | LD50 | subcutaneous | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. | |
| rabbit | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. | |
| rat | LD50 | intraperitoneal | > 1600mg/kg (1600mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. | |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. | |
| rat | LD50 | subcutaneous | > 1200mg/kg (1200mg/kg) | Drugs in Japan Vol. -, Pg. 412, 1990. |