Products Categories
| CAS No.: | 1129634-44-1 |
|---|---|
| Name: | (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID |
| Molecular Structure: | |
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| Formula: | C12H19NO4 |
| Molecular Weight: | 241.287 |
| Synonyms: | (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID;5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-diMethylethyl) ester, (6S)-;(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid;Ledipasvir side chain |
| EINECS: | -0 |
| Density: | 1.23±0.1 g/cm3(Predicted) |
| Boiling Point: | 377.4±35.0 °C(Predicted) |
| Solubility: | Slightly Soluble (3.9 g/L) (25 oC), Calc. |
| PSA: | 66.84000 |
| LogP: | 1.79850 |
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- 1129634-43-0
(6S)-5-tert-butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: (6S)-5-tert-butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate With lithium hydroxide monohydrate; water In ethanol at 20℃; for 20h; Stage #2: With hydrogenchloride In water pH=2; Ice bath; | 100% |
| With water; sodium hydroxide In ethanol for 24h; | 34% |
| With water; lithium hydroxide In tetrahydrofuran; methanol at 60℃; for 16h; | |
| With water; lithium hydroxide In tetrahydrofuran at 20℃; | 2.4 g |
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride In Isopropyl acetate; water at 0℃; pH=3 - 4; | 100% |
- 24424-99-5
di-tert-butyl dicarbonate
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: (S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-di-p-methylbenzoyltartrate With hydrogenchloride In dichloromethane; water for 0.333333h; pH=2-3; Stage #2: di-tert-butyl dicarbonate With sodium hydroxide In dichloromethane; water at 0 - 50℃; pH=10-11; | 100% |
- 1412903-77-5
(6S)-1,1-dibromo-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| With leaded bronze CuSn7Pb15 In methanol; N,N-dimethyl-formamide at 25℃; Reagent/catalyst; Solvent; Electrolysis; | 98% |
| With N-methyl-N,N,N-triethylammonium methylsulfate In N,N-dimethyl-formamide at 25℃; Electrolysis; | 93% |
| With palladium 10% on activated carbon; hydrogen; potassium hydroxide In isopropyl alcohol at 40℃; under 760.051 Torr; Inert atmosphere; | 82% |
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 4h; | 97% |
- 24424-99-5
di-tert-butyl dicarbonate
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: di-tert-butyl dicarbonate; (S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-tartrate With hydrogenchloride In dichloromethane; water pH=2; Stage #2: di-tert-butyl dicarbonate With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 15h; pH=10; | 93% |
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| Stage #1: C13H22BrNO4 With sodium hydride In tetrahydrofuran at 0 - 50℃; for 10h; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 50℃; for 5h; Solvent; Reagent/catalyst; | 92% |
- 1412903-76-4
(6S)-5-tert-butyl 6-methyl 1,1-dibromo-5-azaspiro[2.4]heptane-5,6-dicarboxylate
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| With V-50; hypophosphorous acid; triethylamine In water at 100℃; | 79% |
| Multi-step reaction with 2 steps 1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C 2: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / toluene / 7 h / 110 °C View Scheme |
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| With water; lithium hydroxide In 2-methyltetrahydrofuran at 50℃; | 71% |
- 1262397-12-5
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
- 1129634-44-1
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
| Conditions | Yield |
|---|---|
| With Jones reagent In acetone at 0 - 37℃; for 2h; | 70% |
