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| CAS No.: | 114248-23-6 |
|---|---|
| Name: | 2',2'-DIFLUORO-2'-DEOXYURIDINE |
| Article Data: | 12 |
| Molecular Structure: | |
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|
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| Formula: | C9H10 F2 N2 O5 |
| Molecular Weight: | 264.186 |
| Synonyms: | 2',2'-Difluoro-2'-deoxyuridine;2',2'-Difluorodeoxyuridine; 2'-Deoxy-2',2'-difluorouridine |
| Density: | 1.69±0.1 g/cm3(Predicted) |
| Melting Point: | 147-149掳C |
| PSA: | 104.55000 |
| LogP: | -1.57750 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
- 143157-27-1
((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With ammonia In methanol at 20℃; for 12h; Temperature; | 99% |
| With ammonia In methanol | 99% |
| With ammonia In methanol at 20℃; for 15h; | 95.8% |
- 122111-03-9
gemcitabine hydrochloride
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With acetic acid; sodium nitrite In water at 20℃; for 48h; | 95% |
| Multi-step reaction with 3 steps 1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / Reflux 3: ammonia / methanol / 15 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / Reflux 3: ammonia / methanol / 15 h / 20 °C View Scheme |
- 1201895-94-4
2'-deoxy-2',2'-difluorouridine-3',5'-dibenzoate
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With ammonia In methanol at 23℃; for 23h; | 90% |
- 95058-81-4
gemcitabine
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With hydrogenchloride; isopentyl nitrite In 1,4-dioxane; water at 70℃; Inert atmosphere; | 68% |
| Multi-step reaction with 3 steps 1: dmap; pyridine / 3.5 h / 0 - 20 °C / Inert atmosphere 2: acetic acid / Reflux 3: ammonia / methanol / 20 °C View Scheme |
- 103882-84-4
2’-deoxy-2’,2’-difluoro-cytidine
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With water; acetic acid for 24h; Heating; |
- 122111-03-9
gemcitabine hydrochloride
A
- 114248-23-6
Deoxydifluorouridine
B
- 95058-85-8
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 40℃; for 672h; Mechanism; further reagent, temperature, time; |
- 1445381-44-1
(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: acetic acid / water / 14 h / Reflux 2: ammonia / methanol / 15 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: acetic acid / Reflux 2: ammonia / methanol / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: acetic acid; water / 12 h / 110 °C 2: ammonia / methanol / 12 h / 20 °C View Scheme |
- 1334513-02-8
(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With pyridine; dimethylaluminum chloride In hexane at 0 - 20℃; for 20h; Inert atmosphere; diastereoselective reaction; | 87% |
| Stage #1: Deoxydifluorouridine With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester In tetrahydrofuran at 0 - 20℃; for 1.5h; |
| Conditions | Yield |
|---|---|
| With pyridine; 1H-imidazole at 25 - 50℃; for 12h; Temperature; Inert atmosphere; | 85.5% |
| With pyridine; 1H-imidazole at 20℃; | |
| With 1H-imidazole In pyridine at 20℃; | |
| With 1H-imidazole In N,N-dimethyl-formamide for 8h; Inert atmosphere; |
- 114248-23-6
Deoxydifluorouridine
| Conditions | Yield |
|---|---|
| With pyridine; 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 4h; Inert atmosphere; | 84% |
- Total:33 Page 1 of 1 1
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