115-29-7

EPA Extremely Hazardous Substances List. NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-62 ,1977. .

OSHA PEL: TWA 0.1 mg/m³ (skin)
ACGIH TLV: TWA 0.1 mg/m³ (skin); Not Classifiable as a Human Carcinogen

The Endosulfan is an organic compound with the formula C₉H₆Cl₆O₃S. The systematic name of this chemical is 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide. With the CAS registry number 115-29-7, it is also named as thiodan. The product's categories are Insecticide; 2000/60/EC; Acaricides Alphabetic; EA - Eomethod Specific; 2000/60/ECMore...Close...; Acaricides Pesticides; Alpha sort; Cyc lodienes Pesticides & Metabolites; E; E-GAlphabetic; Endocrine Disruptors (Draft)Method Specific; EPA; European Community: ISO and DIN; Insecticides; Oeko-Tex Standard 100; Pesticides; Pesticides & Metabolites; Pesticides Method Specific. Besides, it should be stored in a cool dry and well-ventilated place.

Physical properties about Endosulfan are: (1)ACD/LogP: 3.13 ; (2)ACD/LogD (pH 5.5): 3.12; (3)ACD/LogD (pH 7.4): 3.12; (4)ACD/BCF (pH 5.5): 139.54; (5)ACD/BCF (pH 7.4): 139.54; (6)ACD/KOC (pH 5.5): 1193.4; (7)ACD/KOC (pH 7.4): 1193.4; (8)#H bond acceptors: 3; (9)Polar Surface Area: 54.74 Å²; (10)Index of Refraction: 1.674; (11)Molar Refractivity: 78.38 cm³; (12)Molar Volume: 208.7 cm³; (13)Polarizability: 31.07×10^-24cm³; (14)Surface Tension: 74.9 dyne/cm; (15)Density: 1.94 g/cm³; (16)Flash Point: 225.8 °C; (17)Enthalpy of Vaporization: 68.12 kJ/mol; (18)Boiling Point: 449.7 °C at 760 mmHg; (19)Vapour Pressure: 7.42E-08 mmHg at 25°C.

Preparation: this chemical can be prepared by hexachlorocyclopentadiene and 1,4 - butylene glycol by heating.

Uses of Endosulfan: it has been used in agriculture around the world to control insect pests including whiteflys, aphids, leafhoppers, Colorado potato beetles and cabbage worms. It has also seen use in wood preservation, home gardening, and tse-tse fly control, though it is not currently used for public health purposes. India is the world's largest consumer of endosulfan. Because of its unique mode of action, it is useful in resistance management;however, because it is non-specific, it can negatively impact populations of beneficial insects.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and toxic in contact with skin and if swallowed. After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer). If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label. Besides, this chemical is irritating to eyes and skin and toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. It is danger of serious damage to health by prolonged exposure through inhalation and very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. It is possible risk of impaired fertility and may cause lung damage if swallowed. When you are using it, wear suitable protective clothing and gloves. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). This material and its container must be disposed of as hazardous waste.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl\C1=C(/Cl)C3(Cl)C(Cl)(Cl)C1(Cl)C2C3COS(=O)OC2
(2)InChI: InChI=1/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2
(3)InChIKey: RDYMFSUJUZBWLH-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2
(5)Std. InChIKey: RDYMFSUJUZBWLH-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	35mg/kg (35mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat	LC50	inhalation	90mg/m3/4H (90mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 72, 1982.
cat	LD50	oral	2mg/kg (2mg/kg)		"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
dog	LD50	oral	76700ug/kg (76.7mg/kg)		Pesticide Manual. Vol. 9, Pg. 332, 1991.
domestic animals - goat/sheep	LD50	oral	26mg/kg (26mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Veterinariya. Veterinary Science. Vol. 59(12), Pg. 64, 1983.
duck	LD50	oral	33mg/kg (33mg/kg)		Down to Earth. Vol. 35, Pg. 25, 1979.
hamster	LD50	intraperitoneal	80mg/kg (80mg/kg)		Archives of Toxicology. Vol. 58, Pg. 152, 1986.
hamster	LD50	oral	118mg/kg (118mg/kg)		European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974.
mammal (species unspecified)	LD50	skin	147mg/kg (147mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Veterinariya. Veterinary Science. Vol. 59(12), Pg. 64, 1983.
man	LDLo	oral	418uL/kg (0.418mL/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE	American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.
man	LDLo	oral	429uL/kg (0.429mL/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 1232, 1992.
man	LDLo	oral	260mg/kg (260mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"	Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 345, 1998.
man	TDLo	oral	86mg/kg (86mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicology, Clinical Toxicology. Vol. 26, Pg. 265, 1988.
mouse	LD50	intraperitoneal	7mg/kg (7mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Bulletin of Environmental Contamination and Toxicology. Vol. 15, Pg. 708, 1976.
mouse	LD50	oral	7360ug/kg (7.36mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Toxicology Letters. Vol. 7, Pg. 221, 1981.
mouse	LD50	unreported	32mg/kg (32mg/kg)		Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. Vol. 16(1), Pg. 45, 1982.
rabbit	LD50	oral	28mg/kg (28mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Veterinariya. Veterinary Science. Vol. 59(12), Pg. 64, 1983.
rabbit	LD50	skin	90mg/kg (90mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Journal of Occupational Medicine. Vol. 9, Pg. 35, 1967.
rabbit	LD50	subcutaneous	360mg/kg (360mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: CONTRACTION (ISOLATED TISSUE)	Residue Reviews. Vol. 22, Pg. 1, 1968.
rat	LC50	inhalation	80mg/m3/4H (80mg/m3)		Journal of Occupational Medicine. Vol. 9, Pg. 35, 1967.
rat	LD50	intraperitoneal	8mg/kg (8mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: CONTRACTION (ISOLATED TISSUE)	Residue Reviews. Vol. 22, Pg. 1, 1968.
rat	LD50	oral	18mg/kg (18mg/kg)		Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 9, 1966.
rat	LD50	skin	34mg/kg (34mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 72, 1982.
rat	LD50	unreported	40mg/kg (40mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 267, 1971.
women	TDLo	intravenous	6uL/kg (0.006mL/kg)	BEHAVIORAL: MUSCLE WEAKNESS LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Journal of Toxicology, Clinical Toxicology. Vol. 34, Pg. 447, 1996.