Products Categories
CAS No.: | 116817-84-6 |
---|---|
Name: | S-(+)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamide |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C9H15NOS |
Molecular Weight: | 185.29 |
Synonyms: | S-(+)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamide;3-THIOPHENEMETHANOL, A-[2-(DIMETHYLAMINO)ETHYL]-;S-(-)-N,N-DIMETHYL-3-HYDROXY-2-THIENYLPROPANAMINE;S(+)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-1-PROPANAMINE;(S)-1-b-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane;3-THIOPHENEMETHANOL, A-[2-(DIMETHYLAMINO)ETHYL]-(9CI);S-(+)-N,N-DiMethyl-3-hydroxy-3-(2-thienyl)-1-propy;(S)-3-(DiMethylaMino)-1-(thiophen-3-yl)propan-1-ol |
Density: | 1.111±0.06 g/cm3(Predicted) |
Melting Point: | 74-76°C |
Boiling Point: | 290.1±30.0 °C(Predicted) |
PSA: | 51.71000 |
LogP: | 1.73320 |
3-(dimethylamino)-1-(thiophen-3-yl)propan-1-one
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; potassium carbonate In methanol |
1-(thiophen-3-yl)-ethanone
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HCl / ethanol 2: aq. K2CO3; NaBH4 / methanol View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; isopropyl alcohol / 6 h / 82 - 83 °C 2: sodium hydroxide; sodium tetrahydroborate / ethanol / 4 h / 20 - 30 °C / Cooling with ice View Scheme |
3-(dimethylamino)-1-(thiophen-3-yl)propan-1-one hydrochloride
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
29.0 g (47.7%) | |
With sodium tetrahydroborate; sodium hydroxide In ethanol at 20 - 30℃; for 4h; Cooling with ice; |
1-Fluoronaphthalene
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
N,N-dimethyl-3-(1-naphthalenyloxy)-3-(3-thienyl)propanamine
Conditions | Yield |
---|---|
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride |
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaH; DMA 2: toluene 3: NaOH; propylene glycol View Scheme |
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaH; DMA 2: toluene View Scheme |
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogenchloride / water; tert-butyl methyl ether / 0.17 h / pH 1 - 1.5 1.2: 1 h / Reflux 2.1: sodium hydroxide / water; ethyl acetate / pH 11 3.1: sodium hydride / water; dimethyl sulfoxide / 0.5 h 3.2: 0.5 h 4.1: ammonia / water; toluene / 1 h 4.2: 1 h / 55 °C 5.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / Reflux View Scheme |
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water; tert-butyl methyl ether / 0.17 h / pH 1 - 1.5 1.2: 1 h / Reflux 2.1: sodium hydroxide / water; ethyl acetate / pH 11 View Scheme |
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water; tert-butyl methyl ether / 0.17 h / pH 1 - 1.5 1.2: 1 h / Reflux 2.1: sodium hydroxide / water; ethyl acetate / pH 11 3.1: sodium hydride / water; dimethyl sulfoxide / 0.5 h 3.2: 0.5 h View Scheme |
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water; tert-butyl methyl ether / 0.17 h / pH 1 - 1.5 1.2: 1 h / Reflux 2.1: sodium hydroxide / water; ethyl acetate / pH 11 3.1: sodium hydride / water; dimethyl sulfoxide / 0.5 h 3.2: 0.5 h 4.1: ammonia / water; toluene / 1 h 4.2: 1 h / 55 °C View Scheme |