1197-21-3

The Phentermine hydrochloride, with the CAS registry number 1197-21-3, is also known as 1-Phenyl-2-methyl-2-aminopropane hydrochloride. It belongs to the product categories of Aminomethyl's; Phenyls & Phenyl-Het; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 214-821-9. This chemical's molecular formula is C₁₀H₁₅N·ClH  and molecular weight is 185.69. What's more, its systematic name is2-Methyl-1-phenyl-2-propanamine hydrochloride (1:1). Its classification codes are: (1)Appetite suppressant [systemic]; (2)Autonomic Agents; (3)Drug / Therapeutic Agent. This chemical is a psychostimulant drug of the phenethylamine class, with pharmacology similar to amphetamine. It is used medically as an appetite suppressant.

Physical properties of Phentermine hydrochloride are: (1)ACD/LogP: 2.155; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.93; (4)ACD/LogD (pH 7.4): -0.28; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.30; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 3.24 Å²; (13)Flash Point: 93.1 °C; (14)Enthalpy of Vaporization: 44.22 kJ/mol; (15)Boiling Point: 206 °C at 760 mmHg; (16)Vapour Pressure: 0.243 mmHg at 25°C.

Uses of Phentermine hydrochloride: it can be used to produce N-(1,1-dimethyl-2-phenethyl)-4-toluenesulfonamide at the ambient temperature. It will need reagent triethylamine and solvent CH₂Cl₂ with the reaction time of 12 hours. The yield is about 99%.

When you are using this chemical, please be cautious about it as the following:
This chemcial is toxic if swallowed. You should not breathe dust. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and gloves. In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.NC(Cc1ccccc1)(C)C
(2)Std. InChI: InChI=1S/C10H15N.ClH/c1-10(2,11)8-9-6-4-3-5-7-9;/h3-7H,8,11H2,1-2H3;1H
(3)Std. InChIKey: NCAIGTHBQTXTLR-UHFFFAOYSA-N

The toxicity data is as follows: