CAS No.1199-18-4,oxidopamine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1199-18-4
Name:	oxidopamine
Article Data:	12

Formula:	C8H11 N O3
Molecular Weight:	169.18
Synonyms:	2,4,5-Trihydroxyphenethylamine;5-(2-Aminoethyl)-1,2,4-benzenetriol; 6-Hydroxydopamine; Dopamine, 6-hydroxy-;Oxidopamine; Topamine
Density:	1.395g/cm³
Boiling Point:	406°Cat760mmHg
Flash Point:	199.3°C
Safety:	Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	86.71000
LogP:	1.00490

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Chemistry

IUPAC Name: 5-(2-Aminoethyl)benzene-1,2,4-triol
Synonyms of 6-Hydroxydopamine (CAS NO.1199-18-4): 2,4,5-Trihydroxyphenethylamine ; 5-(2-Aminoethyl)-1,2,4-benzenetriol ; Hydroxydopamine ; Oxidopamina ; Oxidopaminum ; 1,2,4-Benzenetriol, 5-(2-aminoethyl)-
CAS NO: 1199-18-4
Molecular Formula: C₁₆H₁₉NaO₂
Molecular Weight : 266.3106
Molecular Structure:
H bond acceptors: 4
H bond donors: 5
Freely Rotating Bonds: 6
Polar Surface Area: 30.93 Å²
Index of Refraction: 1.664
Molar Refractivity: 44.98 cm³
Molar Volume: 121.2 cm³
Surface Tension: 76 dyne/cm
Density: 1.395 g/cm³
Flash Point: 199.3 °C
Enthalpy of Vaporization: 68.33 kJ/mol
Boiling Point: 406 °C at 760 mmHg
Vapour Pressure: 3.58E-07 mmHg at 25°C
EINECS: 214-842-3
Form: 6-Hydroxydopamine (CAS NO.1199-18-4) is solid.

Uses

6-Hydroxydopamine (CAS NO.1199-18-4) is a neurotoxin used by scientists to selectively kill dopaminergic and noradrenergic neurons.The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines for treating Parkinson's disease in humans. It is often used in conjunction with a selective noradrenaline reuptake inhibitor (such as desipramine) to selectively kill dopaminergic neurons only.

Toxicity Data With Reference

1.		mmo-sat 100 µg/plate ABCHA6 45,327,81
2.		mma-sat 100 µg/plate ABCHA6 45,327,81

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Specification

1.Reactivity Profile: Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
2.Health Hazard :SYMPTOMS: Symptoms of exposure to oxidopamine may include a prolonged decomposition in catecholamine content of the heart (shown to be due to the destruction of sympathetic nerve endings).