CAS No.1218-35-5,Xylometazoline hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	1218-35-5
Name:	Xylometazoline hydrochloride

Formula:	C₁₆H₂₅ClN₂
Molecular Weight:	280.841
Synonyms:	1H-Imidazole,2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-,monohydrochloride (9CI);2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-,monohydrochloride (8CI);Brizolin;Galazolin;Neo-Rinoleina;Neo-Synephrine II;Novorin;Olynth;Otrivin hydrochloride;Otrivine;Otrivine hydrochloride;Therapin;Xymelin;
EINECS:	214-936-4
Density:	==
Melting Point:	131-133 °C
Boiling Point:	394.2 °C at 760 mmHg
Flash Point:	192.2 °C
Appearance:	white to off-white crystalline powder
Hazard Symbols:	Xn,Xi
Risk Codes:	22-36/37/38
Safety:	36-26
Transport Information:	UN 2811 6.1/PG 3
PSA:	24.39000
LogP:	3.71150

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Chemistry

Molecular structure of Xylometazoline hydrochloride (CAS NO.1218-35-5) is:

Product Name: Xylometazoline hydrochloride
CAS Registry Number: 1218-35-5
IUPAC Name: 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazol-1-ium chloride
Molecular Weight: 280.8361 [g/mol]
Molecular Formula: C₁₆H₂₅ClN₂
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 214-936-4
Melting Point: 131-133 °C
Flash Point: 192.2 °C
Enthalpy of Vaporization: 61.91 kJ/mol
Boiling Point: 394.2 °C at 760 mmHg
Vapour Pressure: 4.56E-06 mmHg at 25°C
Other Registry Number: 28096-10-8 ;8057-34-9
Related Registry Number: 526-36-3 (Parent)
Product Categories: Miscellaneous Natural Products;Adrenoceptor

Uses

Xylometazoline hydrochloride (CAS NO.1218-35-5) is used for the α-adrenergic agonists ligand, with the role of contraction in vascular.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	12500ug/kg (12.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
mouse	LD50	oral	75mg/kg (75mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
mouse	LD50	subcutaneous	53mg/kg (53mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
rat	LD50	intraperitoneal	43mg/kg (43mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
rat	LD50	oral	230mg/kg (230mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.
rat	LD50	subcutaneous	90mg/kg (90mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 555, 1971.

Safety Profile

Hazard Codes Harmful Xn,Xi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36-26
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: NJ2390000

Specification

Xylometazoline hydrochloride , its cas register number is 1218-35-5. It also can be called 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride ; 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-, hydrochloride (1:1) ; 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-, monohydrochloride .