CAS No.12192-57-3,Aurothioglucose Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	12192-57-3
Name:	Aurothioglucose

Formula:	C6H11 Au O5 S
Molecular Weight:	392.20
Synonyms:	D-Glucose,1-thio-, S-gold deriv. (6CI);Gold, (1-thio-D-glucopyranosato)- (8CI);Gold,(1-thio-D-glucopyranosato-O2,S1)-;D-Glucopyranose, 1-thio-, gold complex;(D-Glucopyranosylthio)gold;Aureotan;Auromyose;Aurothioglucose;Aurumine;Authron;Brenol;Glucose, 1-thio-, gold salt (1:1);Glysanol B;Goldthioglucose;Gold, (D-glucopyranosylthio)-;Oronol;Solganal;Solganal B;
EINECS:	235-365-7
Density:	g/cm³
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Hazard Symbols:
Risk Codes:	42/43
Safety:	Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. A deadly human poison by an unspecified route. An experimental poison by intramuscular route. Moderately toxic by subcutaneous and intravenous routes. Human systemic effects: nausea or vomiting, cholestatic jaundice, and eye effects. An experimental teratogen. Other experimental reproductive effects. See also GOLD COMPOUNDS. When heated to decomposition it emits very toxic fumes of SO_x. Used to treat rheumatoid arthritis.
PSA:	115.45000
LogP:	-2.01870

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Chemistry

Chemistry informtion about 1-Aurothio-D-Glucopyranose(CAS NO.12192-57-3) is:
IUPAC Name: gold(1+); (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-thiolateSynonyms: (1-D-Glucosylthio)Gold ;(1-Thio-D-Glucopyranosato)-Gol ;(D-Glucopyranosylthio)-Gol ;(D-Glucopyranosylthio)Gold ;1-Aurothio-D-Glucopyranose ;1-Thio-D-Glucopyranose,Goldcomplex ;1-Thio-D-Glucopyranose,Monogold(1+)Salt ;1-Thio-Glucopyranose,Monogold(1+)Salt
MF: C₆H₁₁AuO₅S
MW: 392.18
EINECS: 235-365-7
Product Categories: Organometallics
Storage temp.: 2-8°C
Merck: 13,887
Following is the molecular structure of 1-Aurothio-D-Glucopyranose(CAS NO.12192-57-3) is:

Uses

1-Aurothio-D-Glucopyranose(CAS NO.12192-57-3) was used to treat rheumatoid arthritis and used to produce experimental obesity in rodents.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	intravenous	1gm/kg (1000mg/kg)		Poultry Science. Vol. 52, Pg. 926, 1973.
chicken	LDLo	intramuscular	300mg/kg (300mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES SPINAL CORD: OTHER DEGENERATIVE CHANGES	Toxicology and Applied Pharmacology. Vol. 35, Pg. 223, 1976.
man	LDLo	unreported	3mg/kg (3mg/kg)		Sammlung von Vergiftungsfaellen. Vol. 10, Pg. 101A, 1939.
man	TDLo	intramuscular	3357ug/kg/4W- (3.357mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Journal of Rheumatology. Vol. 12, Pg. 619, 1985.
man	TDLo	intramuscular	5500ug/kg/10W (5.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Southern Medical Journal. Vol. 88, Pg. 644, 1995.
mouse	LD50	intraperitoneal	2gm/kg (2000mg/kg)	LIVER: OTHER CHANGES	Proceedings of the Society for Experimental Biology and Medicine. Vol. 70, Pg. 498, 1949.
mouse	LDLo	subcutaneous	1650mg/kg (1650mg/kg)		Experimental Medicine and Surgery. Vol. 3, Pg. 146, 1945.
women	TDLo	intramuscular	2600ug/kg/15D (2.6mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: OTHER CHANGES	Arthritis and Rheumatism. Vol. 27, Pg. 230, 1984.
women	TDLo	intramuscular	14402ug/kg/2Y (14.402mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: PROTEINURIS KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Taisha. Molecular Medicine Vol. 12, Pg. 1435, 1975.
women	TDLo	parenteral	2700ug/kg/4W- (2.7mg/kg)	LIVER: "JAUNDICE, CHOLESTATIC"	Journal of Rheumatology. Vol. 11, Pg. 843, 1984.

Consensus Reports

IARC Cancer Review: Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 (1977),p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. A deadly human poison by an unspecified route. An experimental poison by intramuscular route. Moderately toxic by subcutaneous and intravenous routes. Human systemic effects: nausea or vomiting, cholestatic jaundice, and eye effects. An experimental teratogen. Other experimental reproductive effects. See also GOLD COMPOUNDS. When heated to decomposition it emits very toxic fumes of SO_x.
Hazard Codes:
Harmful Xn
Risk Statements:
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements:
S22:Do not breathe dust.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III

Specification

First Aid Measures about 1-Aurothio-D-Glucopyranose(CAS NO.12192-57-3) is:
Ingestion: If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation: If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Skin: In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes: In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.