CAS No.124-63-0,Methanesulfonyl chloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	124-63-0
Name:	Methanesulfonyl chloride
Article Data:	97

Formula:	CH₃ClO₂S
Molecular Weight:	114.553
Synonyms:	Methane Sulfonyl Chloride;Methyl sulfonyl chloride;Chloro methyl sulfone;Mesyl chloride;Methylsulfonyl chloride;Methanesulfonic acid chloride;Methyl sulfochloride;Chloromethyl sulfone;
EINECS:	204-706-1
Density:	1.478 g/cm³
Melting Point:	-33 °C
Boiling Point:	160.7 °C at 760 mmHg
Flash Point:	42.2 °C
Solubility:	Slightly soluble in water, soluble in alcohol and ether
Appearance:	Colorless to yellow liquid
Hazard Symbols:	T+,T,C
Risk Codes:	24/25-26-34-37-35-22-41
Safety:	26-28-36/37/39-45-25
Transport Information:	UN 3246 6.1/PG 1
PSA:	42.52000
LogP:	1.26560

Synthetic route

: 624-92-0
Dimethyldisulphide

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; manganese(IV) oxide; potassium sulfate; water at 60 - 90℃; for 22h; Reagent/catalyst; Temperature; Large scale;	99.81%
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 50℃; for 8h;	90%

: 868-84-8
S,S-dimethyl dithiocarbonate

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine at 5 - 10℃; for 0.25h;	95%

: 2344-80-1
Chloromethyltrimethylsilane

A: 1719-57-9
Chloro(chloromethyl)dimethylsilane

B: 20991-92-8
sulfate de bis-(dimethylchloromethylsilyle)

C: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid at 50 - 80℃;	A n/a B 92% C n/a

...Expand

: 766-92-7
[(methylthio)methyl]-benzene

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation;	91%
With hydrogenchloride; iodosylbenzene for 0.0833333h;	91 % Chromat.

: 71954-24-0
N-chlorodimesylamine

: 3049-24-9
diphenyl phenylphosphonate

A: 102173-66-0
N-Mesyl-triphenoxyphosphinimid

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
In dichloromethane for 18h;	A 82% B n/a

...Expand

: 867-44-7
S-Methylisothiourea sulfate

: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With tert-butylhypochlorite In water; acetonitrile at 0 - 20℃;	79%
In diethyl ether; water at 0 - 20℃; for 0.5h; Green chemistry;	0.808 g

: 34557-54-5
methane

A: 75-09-2
dichloromethane

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 25℃; under 2250.23 Torr; for 1h; Concentration; Wavelength; Irradiation;	A n/a B 69%

: 71954-24-0
N-chlorodimesylamine

A: 29651-24-9
N-Mesyl-trichlorphosphinimid

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus trichloride In dichloromethane; chloroform for 12h;	A 61% B n/a

: 34557-54-5
methane

A: 56-23-5
tetrachloromethane

B: 74-87-3
methylene chloride

C: 75-09-2
dichloromethane

D: 67-66-3
chloroform

E: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; sulfur dioxide; chlorine at 63 - 67℃; under 6750.68 Torr; Photolysis;	A n/a B n/a C n/a D n/a E 55%

...Expand

: 34557-54-5
methane

A: 75-09-2
dichloromethane

B: 67-66-3
chloroform

C: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 65℃; under 2250.23 Torr; for 1h; Temperature; Irradiation;	A n/a B n/a C 54.9%

...Expand

Raw Materials

7143-01-3

2344-80-1

67-68-5

867-44-7

75-75-2

75-18-3

98-07-7

Downstream Products

351-52-0

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Chemistry

IUPAC Name: Methanesulfonyl chloride
Synonyms of Methanesulfonyl chloride (CAS NO.124-63-0): Mesyl chloride ; Methanesulfonic acid chloride ; Methanesulfonyl chloride ; Methanesulphonyl chloride
CAS NO: 124-63-0
Molecular Formula: CH₃ClO₂S
Molecular Weight: 114.54
Molecular Structure:
EINECS: 204-706-1
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 42.52 Å²
Index of Refraction: 1.437
Molar Refractivity: 20.31 cm³
Molar Volume: 77.4 cm³
Surface Tension: 38.9 dyne/cm
Density: 1.478 g/cm³
Flash Point: 42.2 °C
Enthalpy of Vaporization: 38.09 kJ/mol
Boiling Point: 160.7 °C at 760 mmHg
Vapour Pressure: 3.07 mmHg at 25°C
Melting Point: -33°C
Storage temp: Store at R.T.
Sensitive: Moisture Sensitive
Appearance: Colorless to yellow liquid
Solubility: Slightly soluble in water, soluble in alcohol and ether
Product Categories of Methanesulfonyl chloride (CAS NO.124-63-0): Organics

Uses

Methanesulfonyl chloride (CAS NO.124-63-0) is used to make methanesulfonates and to generate sulfene. It is mainly used for the formation of methanesulfonates from alcohols and a non-nucleophilic base.

Production

Here are preparation, manufacture and handling of Methanesulfonyl chloride (CAS NO.124-63-0):
Methanesulfonyl chloride is manufactured either via direct synthesis from methane and sulfuryl chloride in a radical reaction (1):

CH₄ (g) + SO₂Cl₂ (g) → CH₃SO₂Cl + HCl (g) (1)
other method of manufacture starts with methanesulfonic acid, which is accessible out of methane and sulfur trioxide (2) or by vigorous oxidation of methanethiol (3):

CH₄(g) + SO₃ (g) → CH₃SO₃H (l) (2)
CH₃SH + HNO₃ → CH₃SO₃H + H₂O + NOx (3)
The methanesulfonic acid prepared is reacted with thionyl chloride (4) or phosgene (5) to form mesyl chloride:

CH₃SO₃H + SOCl₂ → CH₃SO₂Cl + SO₂ + HCl (4)
CH₃SO₃H + COCl₂ → CH₃SO₂Cl + CO₂ + HCl (5)

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	100uL/kg (0.1mL/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0571119,
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0571119,
mouse	LD50	oral	200mg/kg (200mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0571119,
rat	LCLo	inhalation	620mg/m3/6H (620mg/m3)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Technical Information Service. Vol. OTS0571119,
rat	LD50	oral	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0571119,
rat	LDLo	intraperitoneal	5mg/kg (5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0571119

Safety Profile

Safety Information about Methanesulfonyl chloride (CAS NO.124-63-0):
Hazard Codes: Very T+T, Corrosive C
Risk Statements: 24/25-26-34-37-35-22-41
R22: Harmful if swallowed.
R24/25: Toxic in contact with skin and if swallowed
R26: Very toxic by inhalation.
R34: Causes burns.
R35: Causes severe burns.
R37: Irritating to respiratory system
R41: Risk of serious damage to the eyes.
Safety Statements: 26-28-36/37/39-45-25
S25: Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3246 6.1/PG 1
WGK Germany: 2
RTECS: PB2790000
Hazard Note: Toxic/Corrosive
HazardClass: 6.1
PackingGroup: I