124-63-0

IUPAC Name: Methanesulfonyl chloride
Synonyms of Methanesulfonyl chloride (CAS NO.124-63-0): Mesyl chloride ; Methanesulfonic acid chloride ; Methanesulfonyl chloride ; Methanesulphonyl chloride
CAS NO: 124-63-0
Molecular Formula: CH₃ClO₂S
Molecular Weight: 114.54
Molecular Structure:
EINECS: 204-706-1
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 42.52 Å²
Index of Refraction: 1.437
Molar Refractivity: 20.31 cm³
Molar Volume: 77.4 cm³
Surface Tension: 38.9 dyne/cm
Density: 1.478 g/cm³
Flash Point: 42.2 °C
Enthalpy of Vaporization: 38.09 kJ/mol
Boiling Point: 160.7 °C at 760 mmHg
Vapour Pressure: 3.07 mmHg at 25°C
Melting Point: -33°C
Storage temp: Store at R.T.
Sensitive: Moisture Sensitive
Appearance: Colorless to yellow liquid
Solubility: Slightly soluble in water, soluble in alcohol and ether
Product Categories of Methanesulfonyl chloride (CAS NO.124-63-0): Organics

 Methanesulfonyl chloride (CAS NO.124-63-0) is used to make methanesulfonates and to generate sulfene. It is mainly used for the formation of methanesulfonates from alcohols and a non-nucleophilic base.

Here are preparation, manufacture and handling of Methanesulfonyl chloride (CAS NO.124-63-0): 
 Methanesulfonyl chloride is manufactured either via direct synthesis from methane and sulfuryl chloride in a radical reaction (1):

CH₄ (g) + SO₂Cl₂ (g) → CH₃SO₂Cl + HCl (g) (1)
other method of manufacture starts with methanesulfonic acid, which is accessible out of methane and sulfur trioxide (2) or by vigorous oxidation of methanethiol (3):

CH₄ (g) + SO₃ (g) → CH₃SO₃H (l) (2)
CH₃SH + HNO₃ → CH₃SO₃H + H₂O + NOx (3)
The methanesulfonic acid prepared is reacted with thionyl chloride (4) or phosgene (5) to form mesyl chloride:

CH₃SO₃H + SOCl₂ → CH₃SO₂Cl + SO₂ + HCl (4)
CH₃SO₃H + COCl₂ → CH₃SO₂Cl + CO₂ + HCl (5)

Safety Information about Methanesulfonyl chloride (CAS NO.124-63-0):
Hazard Codes: T+T,C
Risk Statements: 24/25-26-34-37-35-22-41 
R22: Harmful if swallowed. 
R24/25: Toxic in contact with skin and if swallowed 
R26: Very toxic by inhalation. 
R34: Causes burns. 
R35: Causes severe burns. 
R37: Irritating to respiratory system 
R41: Risk of serious damage to the eyes.
Safety Statements: 26-28-36/37/39-45-25
S25: Avoid contact with eyes. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S28: After contact with skin, wash immediately with plenty of soap-suds. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3246 6.1/PG 1
WGK Germany: 2
RTECS: PB2790000
Hazard Note: Toxic/Corrosive
HazardClass: 6.1
PackingGroup: I