CAS No.124-68-5,2-Amino-2-methyl-1-propanol Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	124-68-5
Name:	2-Amino-2-methyl-1-propanol
Article Data:	44
Cas Database

Formula:	C₄H₁₁NO
Molecular Weight:	89.1374
Synonyms:	AMP 75;AMP 90(amine);AMP Regular;Corrguard 75;Hydroxy-tert-butylamine;Isobutanol-2-amine;KV 5088;NSC 441;Pamabron;b-Aminoisobutanol;1,1-Dimethyl-2-hydroxyethylamine;2,2-Dimethylethanolamine;2-Amino-1-hydroxy-2-methylpropane;2-Amino-2,2-dimethylethanol;2-Aminoisobutanol;2-Hydroxy-1,1-dimethylethylamine;2-Hydroxymethyl-2-propylamine;2-Methyl-2-aminopropanol;AMP 100;2-Amino-2-methyl-1-propanol;
EINECS:	204-709-8
Density:	0.93 g/cm³
Melting Point:	24-28 °C(lit.)
Boiling Point:	167.2 °C at 760 mmHg
Flash Point:	67.2 °C
Solubility:	water: 0.1 M at 20 °C, clear, colorless
Appearance:	white crystals or viscous liquid
Hazard Symbols:	Xi,F
Risk Codes:	36/38-52/53
Safety:	61
Transport Information:	2735
PSA:	46.25000
LogP:	0.41630

Synthetic route

: C13H17NO3

A: 90-02-8
salicylaldehyde

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With hydrogenchloride In water at 80℃; for 4h;	A 96% B 80%

: 201230-82-2
carbon monoxide

: 75-31-0
isopropylamine

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With tricresyl phosphate; hydrogen; palladium diacetate In diphenylether at 140℃; under 22502.3 - 60006 Torr; Autoclave;	93%

: 2658-24-4
2,2-dimethylaziridine

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With sulfuric acid In water at 40 - 50℃; for 1h; pH=3 - 5.4;	91%

: 82922-13-2
2-(ethylamino)-2-methylpropanol hydrochloride

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 124-68-5
2-Amino-2-methyl-1-propanol

D: 75-07-0
acetaldehyde

E: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;	A 50% B 44% C 14% D 26% E 66%

...Expand

: 82922-13-2
2-(ethylamino)-2-methylpropanol hydrochloride

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 124-68-5
2-Amino-2-methyl-1-propanol

D: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given;	A 50% B 44% C 14% D 66%

...Expand

: 76-39-1
2-nitro-2-methylpropanol

A: 4706-13-2
N-(1-hydroxy-2-methylprop-2-yl)-hydroxylamine

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With citrate buffer; potassium chloride In ethanol at 30℃; cotrolled potential electrolysis, cathod: Hg, vs. S.C.E.;	A 64% B 25%

: 86241-96-5
2-methyl-3-(vinyloxy)propan-2-amine

A: N-ethylidene-2-methyl-1-vinyloxypropan-2-amine

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With mercury(II) diacetate In benzene Heating;	A 3% B n/a

: 76-39-1
2-nitro-2-methylpropanol

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With methanol; carbon dioxide; nickel at 70℃; under 25742.8 Torr; Hydrogenation;
With methanol; nickel at 30℃; under 25742.8 Torr; Hydrogenation;
With nickel Hydrogenation;

: 1113-49-1
2-methylalanine ethyl ester

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With ethanol; nickel at 100℃; under 257428 Torr; Hydrogenation;

: 62-57-7
2-Aminoisobutyric acid

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With tetrahydrofuran; lithium aluminium tetrahydride
With lithium aluminium tetrahydride In tetrahydrofuran
With sodium tetrahydroborate; iodine In tetrahydrofuran for 20h; Heating;
With sodium tetrahydroborate; iodine In tetrahydrofuran Reflux;
With lithium aluminium tetrahydride In tetrahydrofuran

Raw Materials

13257-67-5

62-57-7

64-17-5

102520-97-8

76-39-1

87730-42-5

1113-49-1

115-11-7

Downstream Products

108-42-9

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History

2-AMINO-2-METHYL-1-PROPANOL(AMP) was collected on the same media used in OSHA Method 60, for diethylene triamine, so those extraction and analytical parameters were used as a starting point for AMP. The AMP was found to readily derivatize with the NITC to form a stable derivative. The samples were extracted with N,N-dimethylformamide (DMF), with a desorption efficiency mean of 100% for the concentration range of 224 to 11.2 μg/tube. The storage study showed no loss for samples stored for up to 14 days under both refrigerated and ambient conditions.

Analytical Methods

Partially evaluated method. This method has been subjected to established evaluation procedures of the Solvents Branch and is presented for information and trial use.

Specification

The CAS register number of 2-Amino-2-methyl-1-propanol is 124-68-5. It also can be called as 1-Propanol, 2-amino-2-methyl- and the IUPAC name about this chemical is 2-amino-2-methylpropan-1-ol. The molecular formula about this chemical is C₄H₁₁NO and the molecular weight is 89.14. It belongs to the following product categories, such as Industrial/Fine Chemicals; Chemical Amines; Aliphatics; Amines and so on. This chemical is stable and combustible. It incompatibles with strong oxidizing agents and it may present an explosion hazard if heated. This chemical can be used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.

Physical properties about 2-Amino-2-methyl-1-propanol are:
(1)ACD/LogD (pH 5.5): -3.7; (2)ACD/LogD (pH 7.4): -3.1; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 2; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 46.25Å²; (11)Index of Refraction: 1.447; (12)Molar Refractivity: 25.61 cm³; (13)Molar Volume: 95.7 cm³; (14)Polarizability: 10.15x10^-24cm³; (15)Surface Tension: 34.4 dyne/cm; (16)Enthalpy of Vaporization: 47.01 kJ/mol; (17)Boiling Point: 167.2 °C at 760 mmHg; (18)Vapour Pressure: 0.566 mmHg at 25°C.

Preparation of 2-Amino-2-methyl-1-propanol:
2-Amino-2-methyl-1-propanol can be prepared by 2-methyl-2-nitro-propan-1-ol, this reaction can also produce b-hydroxyamino-isobutyl alcohol. This reaction will need reagent citrate buffer (pH 4.2), KCl and solvent ethanol. The reaction temperature of 30 ℃. The yield is about 25%. This reaction also need cotrolled potential electrolysis, cathod: Hg, vs. S.C.E.

Uses of 2-Amino-2-methyl-1-propanol:
it can be used to produce 2-(2-hydroxy-ethylamino)-2-methyl-propan-1-o. This reaction will need reagent water.

Safety information of 2-Amino-2-methyl-1-propanol:
When you are using this chemical, please be cautious about it as the following:This chemical is irritating to eyes and skin and it is harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. When you are using it, you need avoid release to the environment. Refer to special instructions / safety data sheets.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(CO)N
(2)InChI: InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3
(3)InChIKey: CBTVGIZVANVGBH-UHFFFAOYSA-N

The toxicity data of 2-Amino-2-methyl-1-propanol is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2150mg/kg (2150mg/kg)		Journal of the American College of Toxicology. Vol. 9(2), Pg. 203, 1990.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat	LD50	oral	2900mg/kg (2900mg/kg)		Journal of the American College of Toxicology. Vol. 9(2), Pg. 203, 1990.