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CAS No.: | 125-33-7 |
---|---|
Name: | Primidone |
Article Data: | 16 |
Molecular Structure: | |
Formula: | C12H14N2O2 |
Molecular Weight: | 218.255 |
Synonyms: | 2-Deoxyphenobarbital;2-Desoxyphenobarbital;5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione;5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione;Resimatil;Roe101;Primakton;Primidon;Pyrimidone Medi-pets;Primacone;Primaclone;Lepimidin;Misodine;Mizolin;Mylepsin;Mysoline;Neurosyn;Sertan;5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione;Hexamidine(antiepileptic);Hexamydin;5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione; |
EINECS: | 204-737-0 |
Density: | 1.138 g/cm3 |
Melting Point: | 281-282 °C |
Boiling Point: | 520.7 °C at 760 mmHg |
Flash Point: | 228.2 °C |
Solubility: | <0.1 g/100 mL at 19 °C |
Appearance: | Crystalline solid |
Hazard Symbols: | Xn |
Risk Codes: | 22-40 |
Safety: | 22-36-45 |
Transport Information: | UN 3249 |
PSA: | 58.20000 |
LogP: | 1.19550 |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In methanol at 20℃; for 5.75h; | 81% |
With ethanol; nickel | |
Multi-step reaction with 2 steps 1: 44 percent / 17 h / 22 °C / Irradiation 2: 42 percent / butan-1-ol / 17 h / 22 °C / Irradiation View Scheme |
Conditions | Yield |
---|---|
for 2h; Product distribution; Further Variations:; reaction time, effect of microwave activation; heterocyclization; Heating; | 79% |
Conditions | Yield |
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at 210℃; for 6h; heterocyclization; | 54% |
2-Ethoxy-5-ethyl-2-dihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione
pirimidone
Conditions | Yield |
---|---|
In butan-1-ol at 22℃; for 17h; Irradiation; | 42% |
With formamide durch Reduktion; | |
With formic acid durch Reduktion; |
5-ethyl-5-phenyl-1H-pyrimidine-4,6-dione
pirimidone
Conditions | Yield |
---|---|
With Pd/SrCO3; ethanol Hydrogenation; | |
With hydrogen; nickel | |
With ethanol; Pd/CaCO3 Hydrogenation; | |
With hydrogen; nickel |
Conditions | Yield |
---|---|
With formamide | |
With formamide |
Conditions | Yield |
---|---|
durch elektrochemische Reduktion; | |
durch elektrochemische Reduktion; |
5-ethyl-2-methoxy-5-phenyl-1H-pyrimidine-4,6-dione
pirimidone
Conditions | Yield |
---|---|
With ethanol; nickel | |
With ethanol; nickel |
S-methyl-2-thiophenobarbital
pirimidone
Conditions | Yield |
---|---|
With ethanol; nickel | |
With ethanol; nickel |
The chemical name of 2-DESOXYPHENOBARBITAL(125-33-7) is Primidone,the IUPAC name is 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione.its molecular formula is C12H14N2O2,with the formula weight is 218.25 g/mol.
CAS No.: 125-33-7
EINECS: 204-737-0
RTECS: UV9100000
RTECS Class: Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
The density of 2-DESOXYPHENOBARBITAL(125-33-7) is 1.138 g/cm3 and it has a flash point of 228.2 °C,The boiling point is 520.7 °C at 760 mmHg .The appearance of 2-DESOXYPHENOBARBITAL(125-33-7) is odorless white crystalline powder. it is slightly bitter taste,no acidic properties and insoluble in water .Following is the structure of 2-DESOXYPHENOBARBITAL(125-33-7):
The chemical synonymous of 2-DESOXYPHENOBARBITAL(125-33-7) are 2-deoxyphenobarbital;2-DESOXYPHENOBARBITAL;5-ETHYLDIHYDRO-5-PHENYL-4,6(1H,5H)-PYRIMIDINEDIONE;5-phenyl-5-ethyl-hexahydropyrimidine-4,6-dione;PRIMIDONE;4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-;5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion;5-Ethyl-5-phenyldihydro-4,6(1H,5H)-pyrimidinedione.
1. | mmo-sat 6666 µg/plate | ENMUDM Environmental Mutagenesis. 8 (Suppl 7)(1986),1. | ||
2. | cyt-hmn:leu 1 mg/L | AJOGAH American Journal of Obstetrics and Gynecology. 116 (1973),867. | ||
3. | orl-wmn TDLo:38 g/kg/7Y-I | DICPBB Drug Intelligence and Clinical Pharmacy. 17 (1983),551. | ||
4. | orl-rat LD50:1500 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),691. | ||
5. | ipr-rat LD50:240 mg/kg | PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 25 (1991),305. | ||
6. | orl-mus LD50:280 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 34 (1975),271. | ||
7. | ipr-mus LD50:332 mg/kg | PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 15 (1981),403. |
child TDLo oral 625mg/kg (625mg/kg) BEHAVIORAL: GENERAL ANESTHETICBEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) British Medical Journal. Vol. 1, Pg. 90, 1957.
mouse LD50 intraperitoneal 332mg/kg (332mg/kg) BEHAVIORAL: ANTICONVULSANT Pharmaceutical Chemistry Journal Vol. 15, Pg. 403, 1981.
mouse LD50 oral 280mg/kg (280mg/kg) Toxicology and Applied Pharmacology. Vol. 34, Pg. 271, 1975.
mouse LD50 unreported 340mg/kg (340mg/kg) BEHAVIORAL: ANTICONVULSANT Russian Pharmacology and Toxicology Vol. 43, Pg. 73, 1980.
rat LD50 intraperitoneal 240mg/kg (240mg/kg) Pharmaceutical Chemistry Journal Vol. 25, Pg. 305, 1991.
rat LD50 oral 1500mg/kg (1500mg/kg) Drugs in Japan Vol. 6, Pg. 691, 1982.
rat LD50 unreported > 2gm/kg (2000mg/kg) British Journal of Pharmacology and Chemotherapy. Vol. 8, Pg. 230, 1953.
women TDLo oral 5mg/kg (5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: HEADACHE
GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 266, Pg. 102, 1954.
women TDLo oral 450mg/kg (450mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ATAXIA
BEHAVIORAL: ANTIPSYCHOTIC Archives of Neurology Vol. 30, Pg. 255, 1974.
women TDLo oral 38gm/kg/7Y-I (38000mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"BEHAVIORAL: TOXIC PSYCHOSIS Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 551, 1983.
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals.Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
3. Personal Protection: Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.