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| CAS No.: | 125-40-6 |
|---|---|
| Name: | BUTABARBITAL |
| Molecular Structure: | |
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| Formula: | C10H16 N2 O3 |
| Molecular Weight: | 212.249 |
| Synonyms: | Barbituricacid, 5-sec-butyl-5-ethyl- (8CI); 5-sec-Butyl-5-ethylbarbituric acid; Butabarb;Butabarbital; Butabarbitone; Butatab; Butatal; Medarsed; NSC 27517; Nilox;Secbubarbital; Secbutabarbital; Secbutobarbitone; Unicelles; sec-Butobarbitone |
| EINECS: | 204-738-6 |
| Density: | 1.101 g/cm3 |
| Melting Point: | 166.5°C |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Solubility: | 848.3mg/L(25 oC) |
| Hazard Symbols: | F,T |
| Risk Codes: | 11-23/24/25-39/23/24/25-25 |
| Safety: | Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. A central nervous system depressant. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES. |
| PSA: | 75.27000 |
| LogP: | 1.45250 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Molecular Formula: C10H16N2O3
Molar mass: 212.25 g/mol
EINECS: 204-738-6
Density: 1.101 g/cm3
Index of Refraction: 1.465
Structure of Butisol (125-40-6):
XLogP3-AA: 1.6
H-Bond Donor: 2
H-Bond Acceptor: 3
IUPAC Name: 5-Butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione
Canonical SMILES: CCC(C)C1(C(=O)NC(=O)NC1=O)CC
InChI: InChI=1S/C10H16N2O3/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,
1-3H3,(H2,11,12,13,14,15)
InChIKey: ZRIHAIZYIMGOAB-UHFFFAOYSA-N
Uses
Butisol (125-40-6) has short duration of action compared to other barbiturates and a particularly fast onset of effects, which makes it useful for certain applications such as relieving anxiety before surgical procedures and treating severe insomnia; however, it is now rarely used because its relatively dangerous particularly when combined with alcohol, although it is still prescribed in South American countries and some Eastern European.
Toxicity Data With Reference
| 1. | ipr-rat LD50:70 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 44 (1932),325. | ||
| 2. | scu-rat LDLo:140 mg/kg | JACSAT Journal of the American Chemical Society. 52 (1930),2440. | ||
| 3. | ipr-mus LDLo:200 mg/kg | JACSAT Journal of the American Chemical Society. 58 (1936),731. | ||
| 4. | ivn-mus LD50:175 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 132 (1961),164. | ||
| 5. | orl-rbt LD50:140 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 44 (1932),325. | ||
| 6. | ipr-rbt LD50:75 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 44 (1932),325. | ||
| 7. | scu-rbt LDLo:200 mg/kg | JACSAT Journal of the American Chemical Society. 45 (1923),243. | ||
| 8. | ivn-rbt LDLo:90 mg/kg | JPPGAR Journal de Physiologie et de Pathologie Generale. 30 (1932),364. |
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. A central nervous system depressant. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.
Specification
Butisol (125-40-6) is a prescription barbiturate sleep aid, and also can be called Butabarbitone ; Secbutabarbital ; Secbubarbital ; Secbutobarbitone and butabarbital .Its intermediate duration of action gives butabarbital an abuse potential slightly lower than Secobarbital.It is also sold in combination with belladonna alkaloids under the brand name Butibel. This product contains a low dose of butabarbital combined with a standardised mix of belladonna alkaloids and is used as an antispasmodic taken to relieve cramping and spasms of the stomach and intestines. They have been used to decrease the amount of acid formed in the stomach. Another similar product is Donnatal , which contains belladonna alkaloids combined with phenobarbital.