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1256388-51-8

Basic Information
CAS No.: 1256388-51-8
Name: Ledipasvir
Molecular Structure:
Molecular Structure of 1256388-51-8 (Ledipasvir)
Formula: C49H54F2N8O6
Molecular Weight: 889.00
Synonyms: Methyl[(2S)-1-{(6S)-6-[5-(9,9-Difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carba-mate
EINECS: 1592732-453-0
Density: 1.42±0.1 g/cm3(Predicted)
Melting Point:
Boiling Point:
Flash Point:
Solubility:
Appearance:
Hazard Symbols:
Risk Codes:
Safety: 24/25
Transport Information:
PSA: 174.64000
LogP: 9.26490
Synthetic route

C59H70F2N8O10

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; dichloromethane at 10℃; for 5h;100%

C63H60Cl2F2N8O8

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
With potassium phosphate In tert-Amyl alcohol; water at 90℃; for 5h;100%
1256388-50-7

(1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

1378387-87-1

methyl ((S)-3-methyl-1-oxo-1-((1R,3S,4S)-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole-2-yl)-2-azabicyclo[2.2.1]heptan-2-yl)butan-2-yl)carbamate

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In tert-Amyl alcohol; water at 90℃; for 16h; Inert atmosphere;90%

C42H43F2N7O3*(x)ClH

111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h;90%

C35H32F2N6*4ClH

111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Stage #1: C35H32F2N6*4ClH; N-methoxycarbonyl-L-valine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: With 4-methyl-morpholine In water; N,N-dimethyl-formamide at 25℃; for 4h;
85.4%

C35H32F2N6*BrH

111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Stage #1: N-methoxycarbonyl-L-valine With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 0.5h;
Stage #2: C35H32F2N6*BrH With triethylamine at 0 - 20℃; for 3h; Reagent/catalyst; Solvent; Temperature;
82.1%

(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester acetone salt

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
In water; acetonitrile at 23℃; for 0.5h;82%

C45H48F2N6O4*ClH

111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.333333h;49%
1256393-27-7

3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Stage #1: 3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.333333h;
Stage #2: N-methoxycarbonyl-L-valine With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h;
76 mg
111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h
1.2: 20 - 30 °C
2.1: ammonium hydroxide / water; ethyl acetate
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen bromide; acetic acid / dichloromethane / 3 h / 20 °C
1.2: 0.83 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane; water / 5 h / 85 - 90 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
3.2: 0.33 h / 20 °C
View Scheme
1256388-49-4

6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen bromide / dichloromethane; acetic acid / 3 h / 20 °C
1.2: 0.83 h / 20 °C
2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 5 h / 85 - 90 °C / Inert atmosphere
3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.33 h / 20 °C
3.2: 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen bromide; acetic acid / dichloromethane / 3 h / 20 °C
1.2: 0.83 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane; water / 5 h / 85 - 90 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
3.2: 0.33 h / 20 °C
View Scheme
1256388-50-7

(1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 5 h / 85 - 90 °C / Inert atmosphere
2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.33 h / 20 °C
2.2: 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; tert-Amyl alcohol / 16 h / 90 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; dichloromethane / 5 h / 10 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane; water / 5 h / 85 - 90 °C / Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
2.2: 0.33 h / 20 °C
View Scheme

C35H32F2N6*4ClH

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 23 °C
1.2: 4 h / 0 - 23 °C
1.3: 15 h
2.1: water; acetonitrile / 0.5 h / 23 °C
View Scheme

(1R,3S,4S)-tert-butyl 3-(6-(7-(2-((S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptan-6-yl)-1H-imidazol-5-yl)-9,9-difluoro-9H-fluoren-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water; acetonitrile / 2 h / 65 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 23 °C
2.2: 4 h / 0 - 23 °C
2.3: 15 h
3.1: water; acetonitrile / 0.5 h / 23 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / acetonitrile; water / 6 h / 65 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.2: 4 h / 25 °C
View Scheme
111398-44-8

(2R)-2-(methoxycarbonyl amino)-3-methylbutanoic acid

1256393-27-7

3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Stage #1: 3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.333333h;
Stage #2: (2R)-2-(methoxycarbonyl amino)-3-methylbutanoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.333333h;
76 mg
111398-44-8

(2R)-2-(methoxycarbonyl amino)-3-methylbutanoic acid

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen bromide / dichloromethane; acetic acid / 3 h / 20 °C
1.2: 0.83 h / 20 °C
2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 5 h / 85 - 90 °C / Inert atmosphere
3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.33 h / 20 °C
3.2: 0.33 h / 20 °C
View Scheme
1256387-73-1

(1R,3S,4S)-2-tert-butoxycarbonyl-3-(2-amino-4-bromophenylaminocarbonyl)-2-azabicyclo[2.2.1]heptane

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ethanol / 130 - 170 °C / Sealed tube
2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 90 °C
3: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme

(1R,3S,4S)-methyl 2-((R)-1-phenylethyl)-2-azabicyclo[2.2.1]heptane-3-carboxylate

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: palladium on carbon; hydrogen / ethanol; methanol / 15 h / 30 - 35 °C / 5171.62 Torr
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 8 - 20 °C
3: lithium hydroxide / methanol; tetrahydrofuran; water / 0.08 h
4: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C
5: ethanol / 130 - 170 °C / Sealed tube
6: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 90 °C
7: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
8: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
9: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
1256387-74-2

(1R,3S,4S)-3-(6-bromo-1H-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 90 °C
2: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium propionate; bis(pinacol)diborane / Isopropyl acetate / 3 h / 75 °C / Inert atmosphere
1.2: 15 h / 75 °C / Inert atmosphere
2.1: hydrogenchloride / acetonitrile; water / 6 h / 65 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C
3.2: 4 h / 25 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride / acetonitrile / 3 h / 60 - 65 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide; ethyl acetate / 16 h / 0 - 30 °C
3: potassium propionate / Isopropyl acetate / 69 - 72 °C / Inert atmosphere
4: potassium phosphate / Isopropyl acetate; water / 2 h / 65 - 72 °C
5: ammonium acetate / toluene; 2-methoxy-ethanol / 5 h / 100 - 102 °C
View Scheme
Multi-step reaction with 4 steps
1.1: bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; potassium acetate / 1,4-dioxane / 80 - 85 °C
2.1: sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; water / 70 - 75 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / 23 °C
4.2: 4 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium propionate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; Isopropyl acetate / 3 h / 70 °C / Inert atmosphere
2.1: aq. phosphate buffer / 0.5 h / 70 °C / Inert atmosphere
2.2: 0.5 h / 35 °C / Inert atmosphere
2.3: 9 h / 55 °C
3.1: hydrogenchloride / water; acetonitrile / 1.5 h / 60 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Autoclave
4.2: 3.5 h / 0 - 20 °C / Autoclave
View Scheme

(1R,3S,4S)-2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C
2: ethanol / 130 - 170 °C / Sealed tube
3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 90 °C
4: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
5: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
1256387-87-7

(1R,3S,4S)-3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane; water / 70 - 75 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / 23 °C
3.2: 4 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triphenylphosphine; potassium carbonate / toluene / 20 - 105 °C
2.1: ammonium hydroxide
3.1: hydrogenchloride / water; acetonitrile / 2 h / 60 - 65 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 1.5 h / 20 - 30 °C
4.2: 20 - 30 °C
4.3: 2 h / 20 - 25 °C
5.1: ammonium hydroxide / water / 10 - 20 °C / pH 9 - 9.5
View Scheme

(6S)-6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane-5-carboxylic acid 1,1-dimethylethyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium propionate; bis(pinacol)diborane / Isopropyl acetate / 3 h / 75 °C / Inert atmosphere
1.2: 15 h / 75 °C / Inert atmosphere
2.1: hydrogenchloride / acetonitrile; water / 6 h / 65 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C
3.2: 4 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: aq. phosphate buffer / 0.5 h / 70 °C / Inert atmosphere
1.2: 0.5 h / 35 °C / Inert atmosphere
1.3: 9 h / 55 °C
2.1: hydrogenchloride / water; acetonitrile / 1.5 h / 60 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Autoclave
3.2: 3.5 h / 0 - 20 °C / Autoclave
View Scheme

(1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 8 - 20 °C
2: lithium hydroxide / methanol; tetrahydrofuran; water / 0.08 h
3: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C
4: ethanol / 130 - 170 °C / Sealed tube
5: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 90 °C
6: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
7: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
1181573-36-3

(1R,3S,4S)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: lithium hydroxide / methanol; tetrahydrofuran; water / 0.08 h
2: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C
3: ethanol / 130 - 170 °C / Sealed tube
4: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 90 °C
5: sodium hydrogencarbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 4 h / 93 °C / Inert atmosphere
6: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C
7: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C
View Scheme
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 3 h / 35 °C / Inert atmosphere
1.2: 3 h / 35 °C
2.1: ammonium acetate / 2-methoxy-ethanol; toluene; ethanol / 18 h / 90 °C
3.1: potassium propionate; bis(pinacol)diborane / Isopropyl acetate / 3 h / 75 °C / Inert atmosphere
3.2: 15 h / 75 °C / Inert atmosphere
4.1: hydrogenchloride / acetonitrile; water / 6 h / 65 °C
5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C
5.2: 4 h / 25 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 25 h / 30 °C
1.2: 1.5 h / 50 °C
2.1: ammonium acetate / toluene; 2-methoxy-ethanol / 7 h / 85 °C
3.1: aq. phosphate buffer / 0.5 h / 70 °C / Inert atmosphere
3.2: 0.5 h / 35 °C / Inert atmosphere
3.3: 9 h / 55 °C
4.1: hydrogenchloride / water; acetonitrile / 1.5 h / 60 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Autoclave
5.2: 3.5 h / 0 - 20 °C / Autoclave
View Scheme

(S)-6-(2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl) 5-tert-butyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ammonium acetate / 2-methoxy-ethanol; toluene; ethanol / 18 h / 90 °C
2.1: potassium propionate; bis(pinacol)diborane / Isopropyl acetate / 3 h / 75 °C / Inert atmosphere
2.2: 15 h / 75 °C / Inert atmosphere
3.1: hydrogenchloride / acetonitrile; water / 6 h / 65 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C
4.2: 4 h / 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ammonium acetate / toluene; 2-methoxy-ethanol / 7 h / 85 °C
2.1: aq. phosphate buffer / 0.5 h / 70 °C / Inert atmosphere
2.2: 0.5 h / 35 °C / Inert atmosphere
2.3: 9 h / 55 °C
3.1: hydrogenchloride / water; acetonitrile / 1.5 h / 60 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Autoclave
4.2: 3.5 h / 0 - 20 °C / Autoclave
View Scheme

1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 7.33 h / 5 - 45 °C
2: potassium phosphate / Isopropyl acetate; water / 2 h / 65 - 72 °C
3: ammonium acetate / toluene; 2-methoxy-ethanol / 5 h / 100 - 102 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / 50 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium dihydrogenphosphate / Isopropyl acetate; water / 80 °C
3: ammonium acetate / toluene / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 50 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium dihydrogenphosphate / Isopropyl acetate; water / 80 °C / Inert atmosphere
3.1: ammonium acetate / toluene / 100 °C
4.1: hydrogenchloride / acetonitrile; water / 2 h / 65 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide
5.2: 20 °C
View Scheme

C49H54F2N6O9

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
With ammonium acetate In 2-methoxy-ethanol; toluene at 100 - 102℃; for 5h;
With ammonium acetate In toluene at 100℃;70 g

3-(6-bromo-1H-benzoimidazol-2-yl)-2-aza-bicyclo[2.2.1]heptane

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide; ethyl acetate / 16 h / 0 - 30 °C
2: potassium propionate / Isopropyl acetate / 69 - 72 °C / Inert atmosphere
3: potassium phosphate / Isopropyl acetate; water / 2 h / 65 - 72 °C
4: ammonium acetate / toluene; 2-methoxy-ethanol / 5 h / 100 - 102 °C
View Scheme
1256389-44-2

C20H25BrN4O3

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium propionate / Isopropyl acetate / 69 - 72 °C / Inert atmosphere
2: potassium phosphate / Isopropyl acetate; water / 2 h / 65 - 72 °C
3: ammonium acetate / toluene; 2-methoxy-ethanol / 5 h / 100 - 102 °C
View Scheme
147-71-7

D-tartaric acid

1256388-51-8

methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester D-tartrate salt

Conditions
ConditionsYield
In ethyl acetate at 23 - 50℃; for 16h;65.6%
at 0 - 20℃;
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    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

    Triumph International Development Limilted is engaged in the API, pharmaceutical intermediates research and developmen.Adhering to the "customer first" business philosophy,we suppl

  •  Triumph International Development Limilted

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-536-7971999

    Address:Yinhai Road,Shouguang

       Inquiry Now

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