CAS No.126-07-8,(+)-Griseofulvin Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	126-07-8
Name:	(+)-Griseofulvin
Article Data:	7

Formula:	C₁₇H₁₇ClO₆
Molecular Weight:	352.771
Synonyms:	Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-;7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;Amudane;Curling factor;Fulcin;Fulvicin;Fulvicin P/G;Fulvicin U/F;Fulvidex;Fulvina;Fulvinil;Fulvistatin;Gricin;Grifulin;Grifulvin;Gris-PEG;Grisactin;Grisefulin;Griseofulvin, (+)-;Grisofulvin;Grisovin;Grysio;Idifulvin;Likuden;Polygris;Poncyl;Spirofulvin;Xuanjing;
EINECS:	204-767-4
Density:	1.38 g/cm³
Melting Point:	218-220 °C(lit.)
Boiling Point:	570.4 °C at 760 mmHg
Flash Point:	228 °C
Solubility:	practically insoluble in water
Appearance:	crystalline solid
Hazard Symbols:	T,Xn
Risk Codes:	60-61-40-43-45
Safety:	53-22-36/37/39-45
PSA:	71.06000
LogP:	2.81030

Synthetic route

: 186581-53-3, 908094-01-9
diazomethane

: 136616-32-5
2'-hydroxygriseofulvin

: 126-07-8
griseofulvin

Conditions

Conditions	Yield
In tetrahydrofuran Ambient temperature;	95%

: 186581-53-3, 908094-01-9
diazomethane

: 469-54-5
(2S,2'R)-7-chloro-4,6-dimethoxy-2'-methyl-3H-spiro[benzofuran-2,1'-cyclohexane]-3,4',6'-trione

A: 469-51-2, 469-52-3, 17818-12-1
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)

B: 126-07-8
griseofulvin

Conditions

Conditions	Yield
With diethyl ether

...Expand

: 67-56-1
methanol

A: 469-51-2, 469-52-3, 17818-12-1
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)

B: 126-07-8
griseofulvin

Conditions

Conditions	Yield
With hydrogenchloride

: 124-41-4
sodium methylate

: 126-07-8, 469-49-8, 1588-01-8, 2884-22-2, 6915-11-3, 67890-77-1, 78739-00-1
(+)-epigriseofulvin

: 126-07-8
griseofulvin

: 17793-63-4, 17793-64-5, 86594-40-3, 86594-41-4, 86594-43-6
(-)-dihydrogriseofulvin

A: 86549-08-8, 86562-90-5
(-)-2',3'-dihydrodehydrogriseofulvin

B: 126-07-8
griseofulvin

Conditions

Conditions	Yield
With selenium(IV) oxide In tert-butyl alcohol for 10h; Heating;

: 3573-90-8
(-)-dehydrogriseofulvin

A: 126-07-8, 469-49-8, 1588-01-8, 2884-22-2, 6915-11-3, 67890-77-1, 78739-00-1
(-)-griseofulvin

B: 126-07-8
griseofulvin

Conditions

Conditions	Yield
Product distribution; microbal transformation by seven streptomyces species;

: 3573-90-8
(-)-dehydrogriseofulvin

: 126-07-8
griseofulvin

Conditions

Conditions	Yield
With 1,4-dihydronicotinamide adenine dinucleotide; pH 7.0 phosphate buffer; Streptomyces cinereocrocatus cell-free culture; NADPH In water; acetone at 28℃; for 5h; Product distribution; effect of NADH/NADPH ratio;

: 7776-77-4
(+/-)-dehydrogriseofulvin

: 126-07-8
griseofulvin

Conditions

Conditions	Yield
In water; acetone at 28℃; for 72h; Streptomyces cinereocrocatus NRRL 3443;

: 7776-77-4
(+/-)-dehydrogriseofulvin

A: 126-07-8, 469-49-8, 1588-01-8, 2884-22-2, 6915-11-3, 67890-77-1, 78739-00-1
(-)-griseofulvin

B: 126-07-8
griseofulvin

Conditions

Conditions	Yield
Product distribution; microbal transformation by seven streptomyces species;

: 186581-53-3, 908094-01-9
diazomethane

norgriseofulvinic acid: norgriseofulvinic acid

A: 469-51-2, 469-52-3, 17818-12-1
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one)

B: 126-07-8
griseofulvin

Conditions

Conditions	Yield
With diethyl ether

...Expand

Raw Materials

17793-63-4

3573-90-8

67-56-1

126-07-8

124-41-4

81325-85-1

469-54-5

60-29-7

Downstream Products

3209-13-0

3573-90-8

126-07-8

Total:208 Page 1 of 6 1 2 3 4 5 6 Next>>

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Chemistry

Molecular Structure:
Molecular Formula: C₁₇H₁₇ClO₆
Molecular Weight: 352.7663
IUPAC Name: (2S,5'R)-7-Chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
Synonyms of Griseofulvin (CAS NO.126-07-8): Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S,6'R)- ; Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)- ; Griseofulvin [USAN:INN:BAN:JAN] ; Fulvidex (Veterinary)
CAS NO: 126-07-8
Classification Code: Agricultural Chemical ; Anti-Infective Agents ; Antibiotics, antifungal ; Antifungal ; Antifungal Agents ; Drug / Therapeutic Agent ; Fungicide, bactericide, wood preservative ; Mutation data ; Natural Product ; Reproductive Effect ; Tumor data
Melting point: 218-220 °C
Index of Refraction: 1.583
Molar Refractivity: 85.27 cm³
Molar Volume: 255.1 cm³
Surface Tension: 52.5 dyne/cm
Density: 1.38 g/cm³
Flash Point: 228 °C
Enthalpy of Vaporization: 85.55 kJ/mol
Boiling Point: 570.4 °C at 760 mmHg
Vapour Pressure: 5.07E-13 mmHg at 25°C

Uses

Griseofulvin (CAS NO.126-07-8) is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is used for the variety of goods to inhibit dermatophytes, including Paper Table is Trichophyton mentagrophytes, Trichophyton mentagrophytes Paper is a small genus spores. Right from tinea versicolor, a white beads containing bacteria and bacterial invalid. Inhibitory effect of the goods, to the vigorous growth of fungal effective. The sensitive goods for tinea capitis caused by fungi, onychomycosis, Diez watts ringworm, tinea pedis objects and body ringworm.

Production

Griseofulvin (CAS NO.126-07-8) was ousted Penicillium (Penicilli-um griseofulvum) Training fermentation liquid extraction system of antibiotics.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	280mg/kg (280mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
mouse	LD50	oral	> 50gm/kg (50000mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
mouse	LD50	subcutaneous	> 12gm/kg (12000mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
rat	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
rat	LD50	intravenous	400mg/kg (400mg/kg)	BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Nature. Vol. 182, Pg. 1320, 1958.
rat	LD50	oral	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. 6, Pg. 215, 1982.

Consensus Reports

IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 , 1976,p. 153.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Safety Profile

Hazard Codes of Griseofulvin (CAS NO.126-07-8): Toxic T, Harmful Xn
Risk Statements: 60-61-40-43-45
R60: May impair fertility.
R61: May cause harm to the unborn child.
R40: Limited evidence of a carcinogenic effect.
R43: May cause sensitization by skin contact.
R45: May cause cancer.
Safety Statements: 53-22-36/37/39-45
S53: Avoid exposure - obtain special instructions before use.
S22: Do not breathe dust.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: WG9800000
Confirmed carcinogen with experimental neoplastigenic and teratogenic data. Poison by intravenous and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. Experimental reproductive effects. Used as an antibiotic, pharmaceutical, and veterinary drug. When heated to decomposition it emits toxic fumes of Cl⁻.

Specification

Precautions: Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.