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| CAS No.: | 128-09-6 |
|---|---|
| Name: | N-Chlorosuccinimide |
| Article Data: | 27 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H4ClNO2 |
| Molecular Weight: | 133.534 |
| Synonyms: | 2,5-Pyrrolidinedione,1-chloro-;Succinimide,N-chloro- (6CI,7CI,8CI);1-Chloro-2,5-pyrrolidinedione;Chlorosuccinimide;Succinchlorimide;Succinic N-chloroimide; |
| EINECS: | 204-878-8 |
| Density: | 1.5 g/cm3 |
| Melting Point: | 144-148 °C |
| Boiling Point: | 200.5 °C at 760 mmHg |
| Flash Point: | 75.1 °C |
| Solubility: | Slightly soluble |
| Appearance: | white to off-white crystalline powder |
| Hazard Symbols: |
 Xi, C
|
| Risk Codes: | 22-34 |
| Safety: | 26-36/37/39-45-37/39 |
| Transport Information: | UN 3261 8/PG 2 |
| PSA: | 37.38000 |
| LogP: | 0.22710 |
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Chemistry
Molecular Structure of N-Chlorosuccinimide (CAS NO.128-09-6):
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IUPAC Name: 1-chloropyrrolidine-2,5-dione
Empirical Formula: C4H4ClNO2
Molecular Weight: 133.5331
Index of Refraction: 1.532
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 37.38Å2
Surface Tension: 50.4 dyne/cm
Molar Refractivity: 27.46 cm3
Molar Volume: 88.6 cm3
Density: 1.5 g/cm3
Flash Point: 75.1 °C
Enthalpy of Vaporization: 43.67 kJ/mol
Boiling Point: 200.5 °C at 760 mmHg
Vapour Pressure: 0.323 mmHg at 25°C
Synonyms of N-Chlorosuccinimide (CAS NO.128-09-6): 1-Chloro-2,5-piperidinedione ; 1-chloro-5-pyrrolidinedione ; 5-Pyrrolidinedione,1-chloro-2 ; imide,n-chloro-succinicaci;n-chloro-succinimid;Pyrrolidinedione, 1-chloro- ; Succinic N-chloroimide ; succinicn-chloroimide
Toxicity Data With Reference
| 1. | orl-rat LDLo:1000 mg/kg | PHRPA6 Public Health Reports. 59 (1944),541. | ||
| 2. | ivn-rat LDLo:200 mg/kg | PHRPA6 Public Health Reports. 59 (1944),541. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Hazard Codes: 
C,
Xi
Risk Statements: 22-34
R22:Harmful if swallowed.
R34:Causes burns.
Safety Statements: 26-36/37/39-45-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37/39:Wear suitable gloves and eye/face protection.
Specification
N-Chlorosuccinimide (CAS NO.128-09-6) is a white crystal, soluble in water and alcohols, it can be used as pharmaceutical intermediates, organic synthesis chlorinating agent, it can also be used to prepare rubber additives, synthesis as chlorinating agent, antibiotic drugs intermediates.
Production method is through the ammoniated acid chloride derived. Through dropping ammonia,react with succinic acid , stirring heated at 102°C steam to get rid of water. Vacuum distillation, collecting 180°C after the distillate to get succinimide. Molten succinimide increased to acetic acid aqueous solution, stirring cooled to 0-5°C, dropping sodium hypochlorite, control reaction in the 8°C below (otherwise there is risk of explosion). To clarify the reaction solution that is reached when the end point, centrifugation, filter cake and washing to neutral, drying, drying to get.