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128-46-1

Basic Information
CAS No.: 128-46-1
Name: Dihydrostreptomycin
Molecular Structure:
Molecular Structure of 128-46-1 (Dihydrostreptomycin)
Formula: C21H41N7O12
Molecular Weight: 583.596
Synonyms: Streptomycin,deoxydihydrohydroxy- (6CI,7CI);Streptomycin, dihydro- (8CI);2,4-Diguanidino-3,5,6-trihydroxycyclohexyl-5-deoxy-2-O-(2-deoxy-2-methylamino-a-L-glucopyranosyl)-3-hydroxymethyl-b-L-lyxo-pentanofuranoside;Abiocine;DHSM;DST;Vibriomycin;
EINECS: 204-888-2
Density: 1.99 g/cm3
Melting Point: >300 °C
Boiling Point: 954.5 °C at 760 mmHg
Flash Point: 531.1 °C
Appearance: Slightly beige solid.
PSA: 334.59000
LogP: -5.17560
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    CAS no. : 128-46-1 English name: Dihydrostreptomycin English synonyms: DHMS; DHSM; Abiocine; Vibriomycin; Dihydro - streptomyci; DIHYDROSTREPTOMYCIN; Benzimidazole, 2 - cyanomethyl; DihydroestreptoMycin Sulfate; Dihydrostreptomycine sulphate; A

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Chemistry

Chemical Name: Dihydrostreptomycin
IUPAC NAME: 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine
CAS No.: 128-46-1
EINECS: 204-888-2
RTECS Class: Mutagen
Molecular Formula: C21H41N7O12
Molecular Weight: 583.59 g/mol
Density: 1.98 g/cm3 
Flash Point: 531.1 °C
Boiling Point: 954.5 °C at 760 mmHg 
 Dihydrostreptomycin (128-46-1) is an antibiotic.Following is the structure:


The chemical synonymous of Dihydrostreptomycin (128-46-1) are Dihydrostreptomycin ; Dihydrostreptomycine sulphate ; Dihydrostreptomycinesulphatesterileusp 

Toxicity Data With Reference

1.    

cyt-mus-par 100 mg/kg

    NULSAK    Nucleus (Calcutta). 2 (1971),161.
2.    

ivn-rat LD50:200 mg/kg

    JOBAAY    Journal of Bacteriology. 53 (1947),205.
3.    

ipr-mus LD50:533 mg/kg

    UPJOH*    Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory .(Kalamazoo, MI.: )1971,2(6).
4.    

scu-rat LD50:1100 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 12 (1962),597.
5.    

ivn-mus LD50:200 mg/kg

    85GDA2    CRC Handbook of Antibiotic Compounds, Volumes 1-9. 1 (1980),96.
6.    

ipr-mus LD50:533 mg/kg

    UPJOH*    Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory .(Kalamazoo, MI.: )1971,2(6).
7.    

scu-mus LD50:1180 mg/kg

    ACHTA6    Antibiotica et Chemotherapia. 11 (1963),2.
8.    

ivn-mus TDLo:200 mg/kg

    85GDA2    CRC Handbook of Antibiotic Compounds, Volumes 1-9. 1 (1980),96.
9.    

ims-mus LD50:350 mg/kg

    AIMDAP    Archives of Internal Medicine. 119 (1967),493.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormalities of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx.
Attention:
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation.