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| CAS No.: | 128-53-0 |
|---|---|
| Name: | N-Ethylmaleimide |
| Article Data: | 24 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H7NO2 |
| Molecular Weight: | 125.127 |
| Synonyms: | Maleimide,N-ethyl- (8CI);1-Ethyl-1H-pyrrole-2,5-dione;Ethylmaleimide;Maleic acidN-ethylimide;NSC 7638; |
| EINECS: | 204-892-4 |
| Density: | 1.207 g/cm3 |
| Melting Point: | 43-46 °C(lit.) |
| Boiling Point: | 210 °C at 760 mmHg |
| Flash Point: | 73.3 °C |
| Solubility: | 1 g/L (20 °C) in water |
| Appearance: | White solid |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 21-28-34-43-20/21 |
| Safety: | 26-28-36/37/39-45-28A |
| Transport Information: | UN 2928 6.1/PG 2 |
| PSA: | 37.38000 |
| LogP: | -0.13080 |
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Chemistry
IUPAC: 1-Ethylpyrrole-2,5-dione
Maleic acid N-ethylimide, Cas Register No. 128-53-0 is also called for Ethylmaleimide ; 5-21-10-00006 (Beilstein Handbook Reference) ; AI3-50085 ; BRN 0112448 ; EINECS 204-892-4 ; Ethylmaleimide ; Maleimide, N-ethyl- ; N-Ethylmaleimide ; NEM ; NSC 7638 ; USAF B-121 ; 1H-Pyrrole-2,5-dione, 1-ethyl- ; Maleimide, N-ethyl- (8CI) and so on.
Molecular Formula: C6H7NO2
Molecular Weight: 125.13
EINECS: 204-892-4
LogP: ACD/LogP: 0.68
XLogP: -0.10
ACD/LogD (pH 5.5): 0.68
ACD/LogD (pH 7.4): 0.68
ACD/BCF (pH 5.5): 1.95
ACD/BCF (pH 7.4): 1.95
ACD/KOC (pH 5.5): 56.15
ACD/KOC (pH 7.4): 56.15
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 1
Index of Refraction: 1.514
Molar Refractivity: 31.2 cm3
Molar Volume: 103.6 cm3
Surface Tension: 42.7 dyne/cm
Density: 1.207 g/cm3
Flash Point: 73.3 °C
Enthalpy of Vaporization: 44.63 kJ/mol
Boiling Point: 210 °C at 760 mmHg
Vapour Pressure: 0.197 mmHg at 25°C
The appearance of Maleic acid N-ethylimide (CAS NO.128-53-0) is white solid.
The molecular structure of Maleic acid N-ethylimide (CAS NO.128-53-0) :
Uses
Maleic acid N-ethylimide, Cas Register No. 128-53-0 is a thiol reactive compound commonly used to modify cystine residues in proteins and peptides. It can be used to irreversibly inhibit the formation of cystine linking in proteins, whereas bifunctional analogues such as p-NN'-phenylenebismaleimide can be used as cross-linking reagent for cystine residues.
Toxicity Data With Reference
| 1. | dni-hmn:oth 6 µmol/L | CNREA8 Cancer Research. 40 (1980),1414. | ||
| 2. | dni-mus:oth 300 µmol/L | BBRCA9 Biochemical and Biophysical Research Communications. 106 (1982),1448. | ||
| 3. | dni-mus:oth 6 µmol/L | CNREA8 Cancer Research. 40 (1980),1414. | ||
| 4. | dni-ham:lng 750 nmol/L | 32YWA5 Radiation Research, Biomedical, Chemical, and Physical Perspectives ,Nygaard, O.F., et al., ed.,New York, NY.: Academic,1975,742. | ||
| 5. | ipr-rat LDLo:17 mg/kg | JMCMAR Journal of Medicinal Chemistry. 15 (1972),534. | ||
| 6. | ipr-mus LD50:25 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) No. AD277-689 . |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by intraperitoneal route. Human mutation data reported. Vapors are highly irritating. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: T+ 
Risk Statements: 21-28-34-43-20/21
R21:Harmful in contact with skin.
R28:Very toxic if swallowed.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R20/21:Harmful by inhalation and in contact with skin.
Safety Statements: 26-28-36/37/39-45-28
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
R45:May cause cancer.
R28:Very toxic if swallowed.
RIDADR: UN 2928 6.1/PG 2
WGK Germany: 3
RTECS: UX9625000
F: 19
HazardClass: 6.1
PackingGroup: II
Specification
1.Treatment of Maleic acid N-ethylimide (CAS NO.128-53-0) in Wastewater ,see as follows:
Total removal:1.86 percent
Total biodegradation:0.09 percent
Total sludge adsorption:1.77 percent
Total to Air:0.00 percent
(using 10000 hr Bio P,A,S)
2.Handling and Storage
Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation.Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Do not store in direct sunlight. Store in a tightly closed container. Store in a dry area. Corrosives area. Keep refrigerated. (Store below 4°C/39°F.) Store under nitrogen.
3.Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH(approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide.