CAS No.13073-35-3,L-ETHIONINE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	13073-35-3
Name:	L-ETHIONINE
Article Data:	14

Formula:	C₆H₁₃NO₂S
Molecular Weight:	163.241
Synonyms:	Butyricacid, 2-amino-4-(ethylthio)-, L- (8CI);Butanoic acid, 2-amino-4-(ethylthio)-,(S)-;ETH;Ethionine;NSC 82393;S-Ethyl-L-homocysteine;S-Ethylhomocysteine;
EINECS:	235-966-4
Density:	1.164 g/cm³
Melting Point:	280 °C (dec.)(lit.)
Boiling Point:	310.391 °C at 760 mmHg
Flash Point:	141.519 °C
Appearance:	White solid
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26
PSA:	88.62000
LogP:	1.24180

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Chemistry

Chemical Name: L-ETHIONINE
IUPAC NAME: 2-amino-4-ethylsulfanylbutanoic acid
CAS No.: 13073-35-3
EINECS: 235-966-4
RTECS: ES6825300
Molecular Formula: C₆H₁₃NO₂S
Molecular Weight: 163.24 g/mol
Density: 1.164 g/cm³
Melting Point: 280 °C (dec.)(lit.)
Flash Point: 141.5 °C
Boiling Point: 310.4 °C at 760 mmHg
Following is the structure of 2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID(13073-35-3):

The chemical synonymous of 2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID(13073-35-3) are 2-amino-4-(ethylthio)-butanoicaci;alpha-amino-gamma-(ethylmercapto)butyricacid;homocysteines-ethylether;l-butyricaci;s-ethyl-homocystein;s-ethyl-l-homocystein;L-ETHIONINE;L-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID.

Uses

2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID(13073-35-3) is a non-proteinogenic amino acid structurally related to methionine, with an ethyl group in place of the methyl group.and it is an antimetabolite and methionine antagonist. It prevents amino acid incorporation into proteins and interferes with cellular use of adenosine triphosphate (ATP). Because of these pharmacological effects, ethionine is highly toxic and is a potent carcinogen.

Production

Product Categories about 2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID(13073-35-3) are Amino Acids;Amino Acids 13C, 2H, 15N;Amino acids methyl、ethyl、t-butyl series;Amino Acids & Derivatives.

Toxicity Data With Reference

1.	dni-esc 2 g/L	CYTOAN Cytologia. 50 (1985),387.
2.	dni-hmn:lym 2 mmol/L	BBACAQ Biochimica et Biophysica Acta. 520 (1979),139.
3.	otr-ham:emb 5 mg/L	CRNGDP Carcinogenesis. 4 (1983),291.
4.	orl-mus TDLo:44,100 mg/kg/2Y-C:CAR	CRNGDP Carcinogenesis. 7 (1986),1143.

5. rat LD intraperitoneal > 1gm/kg (1000mg/kg) LIVER: OTHER CHANGES LIVER: CHANGES IN LIVER WEIGHT Acta Pathologica Japonica. Vol. 39, Pg. 281, 1989.

Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Safety Profile

Questionable carcinogen with experimental carcinogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Hazard Codes:
    Xi: Harmful
Risk Statements about 2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID(13073-35-3):
    R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about 2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID(13073-35-3):
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Specification

An analog of methionine that interferes with the normal methylation of DNA and other methylation pathways, and induces pancreatic toxicity and liver cancer. However, in animal studies, it has also been shown to act synergistically with methionine-depletion to block the growth and metastasis of methionine-dependent tumors.