CAS No.133-10-8,Sodium 4-aminosalicylate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	133-10-8
Name:	Sodium 4-aminosalicylate
Article Data:	3

Formula:	C₇H₆NNaO₃
Molecular Weight:	175.119
Synonyms:	Tubersan;p-Aminosalicylate sodium;p-Aminosalicylic acidsodium salt;Benzoicacid, 4-amino-2-hydroxy-, monosodium salt (9CI);Salicylic acid, 4-amino-,monosodium salt (8CI);4-Aminosalicylic acid sodium salt;Bactylan;Natri-Pas;Nippas;Pasade;Pasalon-Rakeet;Pasnal;Passodico;Salvis;Sanipirol;Sodiopas;Sodium 2-hydroxy-4-aminobenzoate;Sodium 4-amino-2-hydroxybenzoate;Sodium PAS;Sodiump-aminosalicylate;
EINECS:	205-091-2
Density:	1.491g/cm3
Melting Point:	150-151oC, with effervescence
Boiling Point:	380.8 °C at 760 mmHg
Flash Point:	184.1 °C
Appearance:	white crystalline
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	86.38000
LogP:	-0.08090

Synthetic route

: 65-49-6
4-Aminosalicylic acid

: 133-10-8
sodium p-aminosalicylate

Conditions

Conditions	Yield
With sodium carbonate
With sodium hydroxide In water at 20℃;

: 65944-71-0
cytosinium 4-aminosalicylate

: 133-10-8
sodium p-aminosalicylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / Milling 2: sodium hydroxide / water / 20 °C View Scheme

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 7336-20-1
disodium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid

: 133-10-8
sodium p-aminosalicylate

: 74-89-5
methylamine

: C36H28N12O12S2(4-)*4Na(1+)

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; disodium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid Stage #2: sodium p-aminosalicylate Stage #3: methylamine	98%

...Expand

: 22509-74-6
N-ethoxycarbonylphthalimide

: 133-10-8
sodium p-aminosalicylate

: 36467-52-4
2-hydroxy-4-(1,3-dioxoisoindolin-2-yl)benzoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate; triethylamine In water at 5℃; for 5h;	95.1%

: copper(II) chloride monohydrate

: 133-10-8
sodium p-aminosalicylate

: 1277176-65-4
[Cu2(p-aminosalicylato)4(H2O)2]

Conditions

Conditions	Yield
In ethanol reacted for 0.5 h; H2O added slowly, filtered, rinsed with H2O and cold EtOH; elem. anal.;	88%

: 23911-26-4
diethylenetriaminepentaacetic dianhydride

: 133-10-8
sodium p-aminosalicylate

: C28H28N5O14(5-)*5Na(1+)

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 2h;	85%
In dimethyl sulfoxide for 1.5h; Ambient temperature;	55%

: 108-24-7
acetic anhydride

: 133-10-8
sodium p-aminosalicylate

: 50-86-2
4-acetamidosalicylic acid

Conditions

Conditions	Yield
In water at 45℃; for 4h;	84.12%

: copper(II) chloride monohydrate

: 133-10-8
sodium p-aminosalicylate

: 109-76-2
Trimethylenediamine

: 1277176-70-1
[Cu(p-aminosalicylato)2(1,3-propanediamine)2]

Conditions

Conditions	Yield
In ethanol a soln. of Cu salt added to a soln. of Na salt, CH2(CH2NH2)2 added after0.5 h; H2O added slowly, filtered, rinsed with H2O and cold EtOH; elem. anal.;	84%

...Expand

: 133-10-8
sodium p-aminosalicylate

: 20949-66-0
2-methylsulfanyl-thiazol-4-one

: 81059-99-6
2-(4-carboxy-3-hydroxyphenyl)amino-Δ2-thiazolin-4-one

Conditions

Conditions	Yield
In ethanol for 1.5h; Heating;	80%

: 23911-25-3
ethylenediaminetetraacetic dianhydride

: 133-10-8
sodium p-aminosalicylate

: C24H24N4O12(2-)*2Na(1+)

Conditions

Conditions	Yield
With magnesium sulfate In dimethyl sulfoxide at 70℃; for 18h; Inert atmosphere;	80%

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Chemistry

Product Name: Sodium 4-aminosalicylate
Synonyms: 4-Amino-salicylic acid sodium salt
Molecular Structure of Sodium p-aminosalicylate (133-10-8) :
Molecular Formula : C₇H₆NNaO₃
Molecular Weight: 175.12
CAS :133-10-8
EINECS: 205-091-2

Uses

1.Sodium p-aminosalicylate (133-10-8) is used as a disincentive to inhibit growth of Mycobacterium tuberculosis of the amino acid synthesis
2.This product is rarely alone used, often associated with isoniazid, streptomycin and other applications . enhance efficacy and to avoid bacterial resistance.
3.Can also be used for hyperthyroidism. good for hyperthyroidism TB patients, are more applicable in using iodine invalid during the operation, it can create the conditions for surgery when take it short-term
4.Sodium p-aminosalicylate (133-10-8) still has a strong effect on lipid-lowering .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	3850mg/kg (3850mg/kg)	Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 383, 1971.
mouse	LD50	intravenous	3380mg/kg (3380mg/kg)	Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 15(12), Pg. 17, 1980.
mouse	LD50	oral	6900mg/kg (6900mg/kg)	Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
mouse	LD50	subcutaneous	2800mg/kg (2800mg/kg)	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 146, Pg. 466, 1952.
rat	LD50	intraperitoneal	4950mg/kg (4950mg/kg)	Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
rat	LD50	oral	8gm/kg (8000mg/kg)	Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.