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| CAS No.: | 134-50-9 |
|---|---|
| Name: | Acridin-9-amine hydrochloride |
| Molecular Structure: | |
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|
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| Formula: | C13H10 N2 . Cl H |
| Molecular Weight: | 230.71 |
| Synonyms: | 9-Acridinamine,monohydrochloride (9CI); Acridine, 9-amino-, monohydrochloride (8CI);9-Aminoacridine hydrochloride; 9-Aminoacridine monohydrochloride; Acramineyellow; Aminacrine hydrochloride; Monacrin hydrochloride |
| EINECS: | 205-145-5 |
| Density: | 1.268g/cm3 |
| Boiling Point: | 413.5°Cat760mmHg |
| Flash Point: | 233.2°C |
| Appearance: | Pale yellow crystals. One of the most highly fluorescent substances. |
| Safety: | Poison by ingestion. Mutation data reported. See also AMINES. When heated to decomposition it emits very toxic fumes of HCl and NOx. |
| PSA: | 38.91000 |
| LogP: | 4.35340 |
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- 134-50-9
acridin-9-amine hydrochloride
- 110166-26-2
aminacrine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water; ethyl acetate for 0.25h; Concentration; Reagent/catalyst; Solvent; | 100% |
| Conditions | Yield |
|---|---|
| In ethanol; water for 0.25h; Heating; | 99% |
- 52824-42-7
N-(7-bromoheptyl)phthalimide
- 134-50-9
acridin-9-amine hydrochloride
| Conditions | Yield |
|---|---|
| With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h; | 74% |
| Conditions | Yield |
|---|---|
| In pyridine at 70℃; for 24h; | 67.8% |
- 82484-59-1
4-bis-(β-chloroethyl)aminophenyl isocyanate
- 134-50-9
acridin-9-amine hydrochloride
- 1036724-69-2
1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea
| Conditions | Yield |
|---|---|
| With triethylamine In N,N-dimethyl-formamide at 20℃; for 18h; | 60% |
- 93667-91-5
2-(9-bromononyl)isoindoline-1,3-dione
- 134-50-9
acridin-9-amine hydrochloride
| Conditions | Yield |
|---|---|
| With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h; | 55.5% |
| Conditions | Yield |
|---|---|
| With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In dimethyl sulfoxide at 20 - 40℃; for 49h; | 53% |
| Stage #1: acridin-9-amine hydrochloride With triethylamine In water; dimethyl sulfoxide at 20℃; for 1h; Stage #2: 3-Carboxyphenylboronic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; dimethyl sulfoxide at 40℃; for 48h; | 53% |
- 17702-83-9
N-8-bromooctylphthalimide
- 134-50-9
acridin-9-amine hydrochloride
| Conditions | Yield |
|---|---|
| With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h; | 18.5% |
- 134-50-9
acridin-9-amine hydrochloride
A
- 23045-35-4
2-nitro-9-aminoacridine
B
- 157996-62-8
9-amino-2,7-dinitroacridine
| Conditions | Yield |
|---|---|
| With sodium nitrate; sulfuric acid at 0℃; for 0.5h; | A 9.6% B 15% |
| With sodium nitrate; sulfuric acid at 0℃; for 0.5h; | A 9.6% B 15% |
- 24566-79-8
2-(6-bromohexyl)isoindole-1,3-dione
- 134-50-9
acridin-9-amine hydrochloride
| Conditions | Yield |
|---|---|
| With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h; | 15% |
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Chemistry
IUPAC Name: Acridin-9-amine hydrochloride
The MF of Acridin-9-amine hydrochloride (CAS NO.134-50-9) is C13H11ClN2.
The MW of Acridin-9-amine hydrochloride (CAS NO.134-50-9) is 230.69.
Synonyms of Acridin-9-amine hydrochloride (CAS NO.134-50-9): 9-Aminoacridine hydrochloride ; Acridin-9-amine hydrochloride ; 5-Aminoacridine hydrochloride
Apperance: Pale yellow crystals.One of the most highly fluorescent substances
Flash Point: 233.2 °C
Boiling Point: 413.5 °C
EINECS: 205-145-5
Uses
Acridin-9-amine hydrochloride (CAS NO.134-50-9) is used experimentally as a probe for biological membranes and dna.
Production
Acridin-9-amine hydrochloride forms from treatment of 9-aminoacridine with hydrogen chloride. It is amphoteric (reacts both as a weak acid and as a weak base).
Toxicity Data With Reference
| 1. | mmo-sat 10 µg/plate | KSRNAM Kiso to Rinsho. Clinical Report. 16 (1982),6240. | ||
| 2. | mma-sat 50 µg/plate | KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),70. | ||
| 3. | dnr-esc 20 µL/disc | MUREAV Mutation Research. 97 (1982),1. | ||
| 4. | dnr-bcs 20 µL/disc | MUREAV Mutation Research. 97 (1982),1. | ||
| 5. | cyt-ham:lng 600 µg/L | GMCRDC Gann Monograph on Cancer Research. 27 (1981),95. | ||
| 6. | dnd-man:lym 10 pph | BIPMAA Biopolymers. 11 (1972),2537. | ||
| 7. | orl-mus LD50:78 mg/kg | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed., Cleveland, OH.: Chemical Rubber Co.,1969,7 |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Poison by ingestion. Mutation data reported. See also AMINES. When heated to decomposition it emits very toxic fumes of HCl and NOx.Safety information of Acridin-9-amine hydrochloride (CAS NO.134-50-9):
Safety Statements
22 Do not breathe dust
24/25 Avoid contact with skin and eyes
WGK Germany 3
Specification
Flash point data for Acridin-9-amine hydrochloride is not available, but Acridin-9-amine hydrochloride is probably combustible.