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134-72-5

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Basic Information
CAS No.: 134-72-5
Name: Ephedrine sulfate
Molecular Structure:
Molecular Structure of 134-72-5 (Ephedrine sulfate)
Formula: 2(C10H15NO).H2O4S
Molecular Weight: 428.55
Synonyms: Bis[[R-(R*,S*)]-beta-hydroxy-alpha-methylphenethyl methylammonium] sulphate
EINECS: 205-154-4
Density: g/cm3
Melting Point: 248-250 ºC
Boiling Point: 255 °C at 760 mmHg
Flash Point: 85.6 °C
Solubility: Freely soluble in water,sparingly soluble in alcohol.
Appearance: white crystalline powder
Hazard Symbols:
Risk Codes: R22   
Safety: 22-25
PSA: 147.50000
LogP: 3.86560
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Chemistry

Chemical Name: Ephedrine sulfate
CAS No.: 134-72-5
RTECS Class: Tumorigen; Drug; Mutagen; Human Data
Molecular Formula: C10H17NO5S
Molecular Weight: 263.31 g/mol
Melting Point: 248 °C
Following is the structure of Ephedrine sulfate (CAS No.134-72-5):


The chemical synonymous of Ephedrine sulfate (CAS No.134-72-5) are (-)-Ephedrinesulfate(2:1)(Salt ; 1-Alpha-(1-(Methylamino)Ethyl)Benzylalcoholsulfate ; 1-Phenyl-2-Methylamine-Propanol-1-Sulfate ; 2:1)(Salt) ; Alpha-[1-(Methylamino)Ethyl]-Benzenemethano[Theta-(Theta,S)]-Benzenemethanosulfate( ; Isofedrol ; L-Ephedrinesulfate ; Nci-C55652

Toxicity Data With Reference

1.    

ivn-hmn TDLo:1 mg/kg:CVS

    AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 120 (1927),189.
2.    

orl-rat LD50:404 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 94 (1948),150.
3.    

scu-rat LD50:318 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 94 (1948),150.
4.    

ivn-rat LD50:102 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 94 (1948),150.
5.    

orl-mus LD50:812 mg/kg

    NTPTR*    National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-307 ,1986.
6.    

ipr-mus LD50:400 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 28 (1974),227.
7.    

orl-rbt LD50:825 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 94 (1948),150.
8.    

scu-rbt LD50:383 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 94 (1948),150.
9.    

ivn-rbt LD50:73 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 94 (1948),159.

Consensus Reports

NTP Carcinogenesis Studies (feed); No Evidence: mouse, rat NTPTR*    National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-307 ,1986. . Reported in EPA TSCA Inventory.

Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects by intravenous route: increased pulse rate and blood pressure. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also EPHEDRINE.
Hazard Codes: HarmfulXn
Risk Statements about Ephedrine sulfate (CAS No.134-72-5):
R22:Harmful if swallowed.
Safety Statements about Ephedrine sulfate (CAS No.134-72-5):
S22:Do not breathe dust. 
S25:Avoid contact with eyes.
Attention:
1. Storage: Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
2. Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light.