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| CAS No.: | 134855-87-1 |
|---|---|
| Name: | 1-(P-HYDROXYPHENYL)ETHYLAMINE |
| Article Data: | 8 |
| Molecular Structure: | |
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| Formula: | C8H11 N O |
| Molecular Weight: | 137.181 |
| Synonyms: | 1-(4-Hydroxyphenyl)ethylamine;4-(1-Aminoethyl)phenol |
| Density: | 1.096 |
| Boiling Point: | 252℃ |
| Flash Point: | 106℃ |
| Solubility: | Slightly soluble in water. |
| Hazard Symbols: | A severe eye irritant. |
| Risk Codes: | 36 |
| Safety: | A severe eye irritant. When heated to decomposition it emits toxic vapors of NOx. |
| PSA: | 46.25000 |
| LogP: | 2.11220 |
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- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
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- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- Total:15 Page 1 of 1 1
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Chemistry
4-(1-AMINOETHYL)PHENOL(134855-87-1) has the Molecular Formula of C8H11NO , the Molecular Weight of 137.20 .The Hazard Symbol of 4-(1-AMINOETHYL)PHENOL(134855-87-1) is a severe eye irritant.
The structure:
Production
There is synthetic route of 4-(1-AMINOETHYL)PHENOL(134855-87-1).
In the presence of DCC and pyridine,the protected (R)-ornithine (I) was converted to the active ester (III) upon coupling with 2-nitrophenol (II). And then the subsequent reaction is that the nitrophenyl ester (III) with (R)-4-hydroxy-alpha-methylbenzylamine (IV) produced the corresponding amide (V).
The resulting amine (VI) was acylated with diphenylacetyl chloride (VII) to give (VIII),after acid cleavage of the Boc protecting group of (V). Removal of the N-benzyloxycarbonyl group of (VIII) was achieved by catalytic hydrogenation over Pd/C.
With reaction of N,N'-bis(benzyloxycarbonyl)-S-methylisothiourea (X),the resultant amine (IX) was then converted to the protected guanidine (XI).
At last,the protecting groups of (X) were removed by hydrogenation over Pd/C.
Toxicity Data With Reference
| 1. | eye-rbt 100 mg SEV | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539162 . |