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CAS No.: | 135-07-9 |
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Name: | Methyclothiazide |
Molecular Structure: | |
Formula: | C9H11Cl2N3O4S2 |
Molecular Weight: | 360.242 |
Synonyms: | 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine1,1-dioxide;Aquatensen;Ciba 7272-Su;Duretic;Enduron;Enduronum;Eutron;Methyclothiazid;Methyclothiazide;Methycyclothiazide;Methylcyclothiazide;NSC110431;Naturon; |
EINECS: | 205-172-2 |
Density: | 1.613 g/cm3 |
Melting Point: | 223-225oC |
Boiling Point: | 597.928 °C at 760 mmHg |
Flash Point: | 315.416 °C |
Solubility: | 50mg/L(room temperature) |
Appearance: | white crystal powder |
PSA: | 126.33000 |
LogP: | 3.53610 |
Product Name: Methylcyclothiazide (CAS NO.135-07-9)
Molecular Formula: C9H11Cl2N3O4S2
Molecular Weight: 360.24g/mol
Mol File: 135-07-9.mol
Einecs: 205-172-2
Appearance: White crystal powder
Melting Point: 223-225°C
Boiling point: 597.9 °C at 760 mmHg
Flash Point: 315.4 °C
Density: 1.613 g/cm3
Solubility: Easily soluble in acetone
Surface Tension: 55.1 dyne/cm
Enthalpy of Vaporization: 89.05 kJ/mol
Vapour Pressure: 2.93E-14 mmHg at 25°C
XLogP3: 1.4
H-Bond Donor: 2
H-Bond Acceptor: 7
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
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mouse | LD50 | intraperitoneal | 870mg/kg (870mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969. | |
mouse | LD50 | intravenous | 400mg/kg (400mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969. | |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 825, 1982. | |
rat | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969. | |
rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 825, 1982. |
Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.
Methylcyclothiazide ,its CAS NO. is 135-07-9,the synonyms is 2-Methyl-,1,1-dioxide ; 4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2h-2 ; 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sul ; 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine ; 6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazin ; Aquatensen;ciba7272-su ; Duretic .