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135-07-9

Basic Information
CAS No.: 135-07-9
Name: Methyclothiazide
Molecular Structure:
Molecular Structure of 135-07-9 (Methyclothiazide)
Formula: C9H11Cl2N3O4S2
Molecular Weight: 360.242
Synonyms: 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine1,1-dioxide;Aquatensen;Ciba 7272-Su;Duretic;Enduron;Enduronum;Eutron;Methyclothiazid;Methyclothiazide;Methycyclothiazide;Methylcyclothiazide;NSC110431;Naturon;
EINECS: 205-172-2
Density: 1.613 g/cm3
Melting Point: 223-225oC
Boiling Point: 597.928 °C at 760 mmHg
Flash Point: 315.416 °C
Solubility: 50mg/L(room temperature)
Appearance: white crystal powder
PSA: 126.33000
LogP: 3.53610
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  • Methyclothiazide

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    135-07-9

    Methyclothiazide

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Chemistry

Product Name: Methylcyclothiazide (CAS NO.135-07-9)


Molecular Formula: C9H11Cl2N3O4S2
Molecular Weight: 360.24g/mol
Mol File: 135-07-9.mol
Einecs: 205-172-2
Appearance: White crystal powder
Melting Point: 223-225°C
Boiling point: 597.9 °C at 760 mmHg
Flash Point: 315.4 °C
Density: 1.613 g/cm3
Solubility: Easily soluble in acetone
Surface Tension: 55.1 dyne/cm
Enthalpy of Vaporization: 89.05 kJ/mol
Vapour Pressure: 2.93E-14 mmHg at 25°C
XLogP3: 1.4
H-Bond Donor: 2
H-Bond Acceptor: 7

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 870mg/kg (870mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969.
mouse LD50 intravenous 400mg/kg (400mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 825, 1982.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 77, 1969.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 825, 1982.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl.

Specification

 Methylcyclothiazide ,its CAS NO. is 135-07-9,the synonyms is 2-Methyl-,1,1-dioxide ; 4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2h-2 ; 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sul ; 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine ; 6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazin ; Aquatensen;ciba7272-su ; Duretic .