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CAS No.: | 135-97-7 |
---|---|
Name: | Pseudotropine |
Article Data: | 50 |
Molecular Structure: | |
Formula: | C8H15NO |
Molecular Weight: | 141.213 |
Synonyms: | 1aH,5aH-Tropan-3b-ol (8CI);8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, exo-;Pseudotropine(6CI,7CI);3-Pseudotropanol;3b-Tropanol;NSC 43871;y-Tropine;β-Tropanol; Pseudotropine; Exo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; |
EINECS: | 205-226-5 |
Density: | 1.078 g/cm3 |
Melting Point: | 109° |
Boiling Point: | 233 °C at 760 mmHg |
Flash Point: | 112.5 °C |
Appearance: | white crystalline powder |
PSA: | 23.47000 |
LogP: | 0.54180 |
Conditions | Yield |
---|---|
With sodium tetrahydroborate | 91% |
Conditions | Yield |
---|---|
With lithium borohydride In tetrahydrofuran a) -78 deg C, 6 h, b) RT, overnight; | 85% |
With 2-methyl-propan-1-ol; sodium; toluene | |
With lithium borohydride In tetrahydrofuran at -78℃; |
N-(ethoxycarbonyl)nortropacocaine
pseudotropine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 67% |
With lithium aluminium tetrahydride In tetrahydrofuran for 6h; Heating; | 67% |
tropinone hydrochloride
A
8,8'-dimethyl-3,3'-dihydroxy-3,3'-bi(8-azabicyclo<3.2.1>octyl)
C
3-tropanol
D
pseudotropine
Conditions | Yield |
---|---|
With isopropyl alcohol for 22h; Heating; Irradiation; PRK-2 mercury-quartz lamp; | A 5% B 22% C 46% D 32% |
tropinone hydrochloride
isopropyl alcohol
A
8,8'-dimethyl-3,3'-dihydroxy-3,3'-bi(8-azabicyclo<3.2.1>octyl)
C
3-tropanol
D
pseudotropine
Conditions | Yield |
---|---|
for 22h; Heating; Irradiation; PRK-2 mercury-quartz lamp; | A 5% B 22% C 46% D 32% |
Conditions | Yield |
---|---|
With hydrogenchloride at 185 - 190℃; im Rohr; |
Conditions | Yield |
---|---|
elektrolytischen Reduktion,in alkal.Loesung; | |
elektrolytischen Reduktion,in alkal.Loesung;weitere Nebenprodukt:Tropan; | |
With hydrogen iodide; zinc at 0℃; weitere Nebenprodukt:Tropan; |
Conditions | Yield |
---|---|
With aluminum isopropoxide; isopropyl alcohol | |
With sodium tetrahydroborate In ethanol for 1h; | A 91 mg B 519 mg |
tropinone
A
8,8'-dimethyl-3,3'-dihydroxy-3,3'-bi(8-azabicyclo<3.2.1>octyl)
B
pseudotropine
Conditions | Yield |
---|---|
With sodium amalgam |
Tropanol
pseudotropine
Conditions | Yield |
---|---|
elektrolytischen Oxydation in saurer oder swach alkalischer Loesung;arbeitet ohne Diaphragma an der Kathode; |
Molecular structure of Pseudotropine (CAS NO.135-97-7):
Product Name: Pseudotropine
CAS Registry Number: 135-97-7
IUPAC Name: 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
Molecular Weight: 141.2108 g/mol
Molecular Formula: C8H15NO
XLogP3-AA: 0.8
H-Bond Donor: 1
H-Bond Acceptor: 2
Index of Refraction: 1.526
Molar Refractivity: 40.199 cm3
Molar Volume: 130.992 cm3
Surface Tension: 39.584 dyne/cm
Density: 1.078 g/cm3
Flash Point: 112.53 °C
Enthalpy of Vaporization: 54.599 kJ/mol
Boiling Point: 232.999 °C at 760 mmHg
Vapour Pressure: 0.011 mmHg at 25°C
Classification Code Pseudotropine (CAS NO.135-97-7): Drug / Therapeutic Agent
EINECS: 205-226-5
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | Annales de Chimie. Vol. 7, Pg. 537, 1962. | |
rabbit | LD50 | intravenous | > 50mg/kg (50mg/kg) | Annales de Chimie. Vol. 7, Pg. 537, 1962. |
Pseudotropine (CAS NO.135-97-7) also can be called 3-Pseudotropanol ; 3-beta-Tropanol ; 3beta-Tropanol ; 5-21-01-00219 (Beilstein Handbook Reference) ; BRN 0080189 ; NSC 43871 ; Pseudotropanol ; exo-8-Methyl-8-azabicyclo(3.2.1)octan-3-ol ; psi-Tropine ; 1-alpha-H,5-alpha-H-Tropan-3-beta-ol ; 1alphaH,5alphaH-Tropan-3beta-ol (8CI) ; 8-Azabicyclo(3.2.1)octan-3-ol, 8-methyl-, exo- (9CI) ; exo-8-Methyl-8-azabicyclo(3.2.1)octan-3-ol .