CAS No.13734-41-3,(S)-2-(Boc-amino)-3-methylbutyric acid Suppliers

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Basic Information

Molecular Structure:
CAS No.:	13734-41-3
Name:	(S)-2-(Boc-amino)-3-methylbutyric acid
Article Data:	160

Formula:	C₁₀H₁₉NO₄
Molecular Weight:	217.265
Synonyms:	N-BOC-valine;N-a-tert-Butoxycarbonyl-L-valine;NSC 197197;tert-Butoxycarbonyl-L-valine;Boc-Val-OH;Valine,N-carboxy-, N-tert-butyl ester, L- (6CI,8CI);(S)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic acid;(S)-N-tert-Butoxycarbonylvaline;BOC-valine;
EINECS:	237-307-6
Density:	1.079 g/cm³
Melting Point:	77-80 °C(lit.)
Boiling Point:	341.8 °C at 760 mmHg
Flash Point:	160.5 °C
Solubility:	insoluble
Appearance:	white fine crystalline powder
Hazard Symbols:	Xn
Risk Codes:	20/21/22-36/37/38
Safety:	24/25-36-26
PSA:	75.63000
LogP:	2.01120

Synthetic route

: 72-18-4
L-valine

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;	100%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h;	100%

: 95499-91-5
Boc-Val-NHNHPh

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With oxygen In acetonitrile for 16h; tyrosinase, phosphate buffer pH 7;	99%
With phosphate buffer; oxygen; tyrosinase In water; acetonitrile at 20℃; for 16h; pH=7.0;	99%

: 128359-98-8
Boc-Val-O-t-Bu

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With cerium(III) chloride; sodium iodide In acetonitrile for 6h; Heating;	99%
With water; iodine In acetonitrile for 5h; Heating;	89%

: 72-18-4
L-valine

: 104272-92-6
2-t-butoxycarbonyloxy-3,6-diisopropylpyrazine

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile for 24h; Ambient temperature;	98%

: (S)-(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate

A: 13734-41-3
t-Boc-L-valine

B: 1033736-87-6
C16H10O3S

Conditions

Conditions	Yield
In chloroform-d1 for 0.233333h; Photolysis; Inert atmosphere;	A 97% B n/a

: 72-18-4
L-valine

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

A: 142-08-5
2-hydroxypyridin

B: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 9h; Ambient temperature;	A n/a B 92%

...Expand

: 72-18-4
L-valine

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
Stage #1: L-valine With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; Stage #2: 2,2-dimethylpropanoic anhydride In tetrahydrofuran; water at 0 - 20℃; for 12h;	90%

: 66447-55-0
((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With formic acid; potassium hydroxide In ethanol at 70℃; for 1h;	89%
With hydrogen; palladium on activated charcoal

: 58561-04-9
N-tert-butoxycarbonyl-L-valine methyl ester

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With lithium hydroxide In methanol for 8h;	85%
With water; lithium hydroxide In methanol for 4h;

: 72-18-4
L-valine

: 75844-68-7
tert-butyl 2-oxo-1,3-oxazole-3(2H)-carboxylate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With dmap; triethylamine In 1,4-dioxane; water for 15h; Ambient temperature;	84%

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Chemistry

Synonyms: BOC-VALINE;BOC-VALINE-OH;BOC-VAL-OH;BOC-VAL;BOC-L-VAL;BOC-L-VALINE;BOC-L-VAL-OH
Molecular formula: C₁₀H₁₉NO₄
Molar weight: 217.26
Molecular Structure:
Product Categories: Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series;Pharmaceutical intermediate
mp : 77-80 ℃(lit.)
alpha : -6.3 ^o(c=1,CH₃COOH)
refractive index : -6.5 ° (C=1, AcOH)
storage temp.: -20℃

Uses

Uses in the multi-peptide synthesis, serves as the amino acid protection monomer. Patterned SILK past Lu Wei intermediate .

Safety Profile

Hazard Codes :Xn
The Risk Statements information of Boc-L-Valine:
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Boc-L-Valine:
26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36: Wear suitable protective clothing
24/25: Avoid contact with skin and eyes
WGK Germany : 3