CAS No.1405-20-5,Polymyxin B sulfate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	1405-20-5
Name:	Polymyxin B sulfate

Formula:	C₅₆H₉₈N₁₆O₁₃^.H₂SO₄
Molecular Weight:	1301.56
Synonyms:	Campho-Phenique Antibiotic Plus Pain Relief Ointment;Ophthocort;Neosporin Plus;Dexacidin;Neobacimyx (Veterinary);Polymixin B sulfate (JP14);Aerosporin (TN);Poly-Pred;Drotic;Pediotic Suspension;Statrol;2-[(4-amino-2-formamido-butanoyl)amino]-N-[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]-4-hydroxy-butanamide; sulfuric acid;Neosporin;Aerosporin;Chloromyxin;Otocort;Mastimyxin;
EINECS:	215-774-7
Melting Point:	217-220°C (dec.)
Boiling Point:	1651ºC at 760 mmHg
Flash Point:	952.3ºC
Solubility:	water: 50 mg/mL
Appearance:	White crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	22-24/25
PSA:	573.64000
LogP:	2.54990

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Chemistry

Molecular Formula: C₅₆H₁₀₀N₁₆O₁₇S
Molecular Weight: 1301.56
EINECS: 215-774-7
Flash Point: 952.3 °C
Enthalpy of Vaporization: 272.45 kJ/mol
Boiling Point: 1651 °C at 760 mmHg
Storage tempreture: 2-8 °C
Solubility: H₂O: 50 mg/mL
Form: Powder
Structure of Polymyxin B sulfate (CAS NO.1405-20-5):

Product Category of Polymyxin B sulfate (CAS NO.1405-20-5): Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity;PeptidesCell Signaling and Neuroscience;Antibiotics;Reagents and Supplements

Uses

Polymyxin B sulfate (CAS NO.1405-20-5) is used for resistant gram negative infections as an antibiotic. In addition to its antibiotic function, it has been used to clear endotoxin contamination in reagents

Toxicity Data With Reference

1.	dnd-esc 50 mg/L	MUREAV Mutation Research. 89 (1981),95.
2.	orl-mus LD50:790 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
3.	ipr-mus LD50:20,500 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
4.	scu-mus LD50:59,500 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
5.	ivn-mus LD50:5400 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
6.	ivn-dog LDLo:8 mg/kg	INURAQ Investigative Urology. 6 (1969),505.
7.	ice-dog LDLo:320 µg/kg	BJPCAL British Journal of Pharmacology and Chemotherapy. 23 (1964),552.

Safety Profile

Poison by intravenous, subcutaneous, intraperitoneal and intracerebral routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x and NO_x. See also POLYMYXIN B.
Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.

Specification

Polymyxin B sulfate , its cas register number is 1405-20-5. It also can be called N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide sulfuric acid .

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