CAS No.141-95-7,MALONIC ACID DISODIUM SALT Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	141-95-7
Name:	MALONIC ACID DISODIUM SALT
Article Data:	4

Formula:	C₃H₂Na₂O₄
Molecular Weight:	148.026
Synonyms:	Malonicacid, disodium salt (8CI);Propanedioic acid, disodium salt (9CI);Disodiummalonate;Sodium malonate;
EINECS:	205-514-0
Density:	2.08 g/cm3
Boiling Point:	386.8 °C at 760 mmHg
Flash Point:	201.9 °C
Solubility:	1 M at 20 °C, clear, colorless in water
Appearance:	white crystalline powder
Safety:	22-24/25
PSA:	80.26000
LogP:	-3.12370

Synthetic route

: 141-82-2
malonic acid

: 1310-73-2
sodium hydroxide

: 141-95-7
sodium malonate

Conditions

Conditions	Yield
In water neutralization reaction with stoich. amt. at pH 6-7;

: sodium α-sodium acetate

: 124-38-9
carbon dioxide

: 141-95-7
sodium malonate

: Na2[Cu(malonate)2(H2O)2]

: 79-19-6
thiosemicarbazide

A: C2H10CuN6S2(2+)*C3H2O4(2-)

B: 141-95-7
sodium malonate

Conditions

Conditions	Yield
In water

...Expand

: 141-95-7
sodium malonate

: 98-88-4
benzoyl chloride

A: 93-97-0
benzoic acid anhydride

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With Pyridine 1-oxide hydrochloride In dichloromethane; water at 18℃; Rate constant;	A 13% B 87%

...Expand

: 290-37-9
1,4-pyrazine

: cadmium(II) nitrate tetrhydrate

: 141-95-7
sodium malonate

: [Cd(μ-malonato)(μ-pyrazine)0.5(H2O)](n)

Conditions

Conditions	Yield
With tetramethylammonium chloride In water a soln. of Cd salt reated with a soln. of sodium malonate, stirred for 10 min, an aq. mixt. of pyrazine and tetramethylammonium chloride added slowly; filtered, crystd. for 1 wk in an open atmosphere, sepd., washed (H2O), dried; elem. anal.;	85%

...Expand

: (η5-cyclopentadienyl)(dicarbonyl){(2R,5S,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-ethoxy-5,6-dihydro-2H-pyran-5-yl}molybdenum

: 141-95-7
sodium malonate

: (η5-cyclopentadienyl)(dicarbonyl){(2R,3R,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-(1,3-dioxo-1,3-dimethoxy-2-propyl)-5,6-dihydro-2H-pyran-5-yl}molybdenum

Conditions

Conditions	Yield
In tetrahydrofuran under Ar; addn. of freshly prepared sodium malonate in THF to suspn. of Mo-complex in THF (molar ratio 3:1, stirred, 0°C), stirred (15 min, 0°C), quenched (satd. NH4Cl soln.); extn. (CH2Cl2, three times), drying (over Na2SO4), filtration, concn., flash chromy. (1:1 degassed hexanes/ethyl acetate), recrystn. (degassed hexanes/CH2Cl2); elem. anal.;	82%

: 21264-30-2, 14592-56-4, 90243-59-7
trans-bis(acetonitrile)palladium(II) chloride

: 7732-18-5
water

: 141-95-7
sodium malonate

: sodium cis-dichloromalonatopalladate(II) dihydrate

Conditions

Conditions	Yield
at 20℃;	82%

...Expand

: 4916-57-8
1,2-bis(4'-pyridyl)ethane

: 141-95-7
sodium malonate

Cu(NO3)2.3H2O: Cu(NO3)2.3H2O

polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2: polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2

Conditions

Conditions	Yield
Stage #1: sodium malonate; Cu(NO3)2.3H2O In methanol; water for 0.5h; Stage #2: 1,2-bis(4'-pyridyl)ethane In methanol; water for 4h; Heating; Further stages.;	80%

...Expand

: 66-71-7
1,10-Phenanthroline

: manganese(II) chloride tetrahydrate

: 7732-18-5
water

: 141-95-7
sodium malonate

: [Mn(II)2(malonate)(1,10-phenanthroline)3(H2O)2Cl]Cl

Conditions

Conditions	Yield
In methanol; water aq. soln. of malonate was added dropwise to MeOH soln. of Mn salt with stirring for 30 min, to this mixt. MeOH soln. of phenanthroline was addedslowly and stirred for 2 h, then refluxed for 6 h; mixt. was cooled, filtered, filtrate was kept in CaCl2-desiccator for several days, ppt. was filtered off, washed and dried; elem. anal.;	80%

...Expand

: 553-26-4
4,4'-bipyridine

: manganese(II) chloride tetrahydrate

: 141-95-7
sodium malonate

: [Mn2(malonate)2(H2O)2(4,4'-bipyridine)]n

Conditions

Conditions	Yield
In methanol; water soln. MnCl2*4H2O in MeOH was allowed to react with aq. soln. disodium malonate for 20 min, MeOH soln. 4,4'-bipy was added and stirred for 2 h; soln. was filtered and evapd. slowly, crystals were filtered off, washedwith 2-propanol and dried; elem. anal.;	80%

...Expand

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Chemistry

IUPAC Name: Disodium propanedioate (141-95-7)
Synonyms: Malonicacid,sodiumsalt ; Sodiumpropanedioate ; Sodium malonate ; Sodium malonite ; Propanedioic acid disodium salt ; Methanedicarboxylic acid disodium salt ; Malonic acid disodium salt ; Disodium malonate
Molecular Structure:
Molecular Formula : C₃H₂Na₂O₄
Molecular Weight: 148.03
CAS : 141-95-7
EINECS: 205-514-0
Flash Point: 201.9 °C
Enthalpy of Vaporization: 69.8 kJ/mol
Boiling Point: 386.8 °C at 760 mmHg
Vapour Pressure: 4.66E-07 mmHg at 25°C
solubility H₂O: 1 M at 20 °C, clear, colorless
Stability: Stable. Incompatible with strong oxidizing agents.
Appearance: Sodium malonate (141-95-7) is white crystalline powder
Solution:Soluble in water, insoluble in alcohol, ether and benzene.

Uses

Sodium malonate (141-95-7) is used for raw material of pharmaceutical, dye and fragrance ; organic synthesis.

Production

Derive by mixing malonic acid with sodium hydroxide solution; Industrial production often add chloroacetic acid with sodium cyanide to get cyanuric acid, and then through the role of liquid caustic soda sodium malonate. The chloroacetic acid dissolved in water at 15 ℃ below with saturated sodium carbonate solution to pH7.0, and then adding sodium cyanide solution at 45 ℃, at 105-110 ℃ reaction to 30min, adding 45-55% sodium hydroxide, reaction at the 100-105 ℃ 1.5h, concentrated solution of sodium malonic too dry to obtain Sodium malonate (141-95-7).

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1550mg/kg (1550mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
mouse	LD50	intravenous	2100mg/kg (2100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
rabbit	LD50	intravenous	660mg/kg (660mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
rabbit	LDLo	subcutaneous	1584mg/kg (1584mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD ENDOCRINE: HYPERGLYCEMIA	Journal of Biological Chemistry. Vol. 161, Pg. 55, 1945.
rat	LD50	intraperitoneal	1100mg/kg (1100mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 814, 1965.

Safety Profile

Safety Statements: 22-24/25
22: Sodium malonate (141-95-7) is harmful if swallowed
24/25: Toxic in contact with skin and if swallowed
WGK Germany: 3
RTECS: OO1750000