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CAS No.: | 1421-86-9 |
---|---|
Name: | STRYCHNINE HYDROCHLORIDE |
Article Data: | 1 |
Molecular Structure: | |
Formula: | C21H22N2O2.ClH |
Molecular Weight: | 370.879 |
Synonyms: | Strychnidin-10-one,monohydrochloride (9CI);Strychnine, monohydrochloride (8CI);Strychnine hydrochloride; |
EINECS: | 215-826-9 |
Melting Point: | 295 °C |
Boiling Point: | 578.8 °C at 760 mmHg |
Flash Point: | 303.8 °C |
Hazard Symbols: | T+,N |
Risk Codes: | 26/27/28-51/53 |
Safety: | 22-36/37/39-45-61-60 |
Transport Information: | UN 1692 6.1/PG 1 |
PSA: | 32.78000 |
LogP: | 2.89740 |
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate |
Conditions | Yield |
---|---|
In not given in hot dild. soln.; washing with H2O and alcohol, drying at 100°C; | |
Conditions | Yield |
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In water hot soln.; cooling; | |
In water |
strychnine hydrochloride
Conditions | Yield |
---|---|
In water heating Ag(Cr(C2O4)2(CH3NHC2H4NHCH3)*H2O with H2O and strychninium chloride on water bath with frequent shaking, until soln. is free ofCl(1-), storing filtered soln. for several days;; pptn.; |
strychnine hydrochloride
Conditions | Yield |
---|---|
In water prepn. from aq. solns. of strychninium chloride and K(Cr(C2O4)2(C5H5N)2)*3H2O;; |
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Strychnine hydrochloride (1421-86-9) is also called for Certox ; Strychnos hydrochloride ; Strychnine HCl ; Strychnidin-10-one,monohydrochloride ; strychnine,monohydrochloride ; Strychnine hydrochloride hydrate and so on.
Molecular Formula: C21H23ClN2O2
Molecular Weight: 370.87
EINECS: 215-826-9
Melting Point: 295 °C
Flash Point: 292.4 °C
Boiling Point: 559.9 °C at 760 mmHg
LogP: ACD/LogP: 1.74
ACD/LogD (pH 5.5): -0.95
ACD/LogD (pH 7.4): 0.7
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1.14
ACD/KOC (pH 5.5): 1
ACD/KOC (pH 7.4): 19.31
H bond acceptors: 4
H bond donors: 0
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 0
Undefined Atom StereoCenter Count: 6
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 2
Enthalpy of Vaporization: 84.23 kJ/mol
The molecular structure of Strychnine hydrochloride (1421-86-9):
Strychnine hydrochloride (1421-86-9) is used as glycine agents, which mean substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | subcutaneous | 460ug/kg (0.46mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Zentralblatt fuer Veterinaermedizin, Reihe A. Vol. 16, Pg. 465, 1969. |
mouse | LD50 | intravenous | 650ug/kg (0.65mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 12, 1945. |
rat | LD50 | subcutaneous | 2730ug/kg (2.73mg/kg) | BEHAVIORAL: REGIDITY | Zentralblatt fuer Veterinaermedizin, Reihe A. |
RTECS: WL2430000
Hazard Codes: T+ ,N
Risk Statements: 26/27/28-51/53
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 22-36/37/39-45-61-60
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S61: Avoid release to the environment. Refer to special instructions safety data sheet
S60: This material and/or its container must be disposed of as hazardous waste
RIDADR: UN 1692 6.1/PG 1
WGK Germany 3
HazardClass: 6.1(a)
PackingGroup: I