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| CAS No.: | 14439-61-3 |
|---|---|
| Name: | 4'-CHLORODIAZEPAM |
| Article Data: | 7 |
| Molecular Structure: | |
|
|
|
| Formula: | C16H12 Cl2 N2 O |
| Molecular Weight: | 319.19 |
| Synonyms: | 2H-1,4-Benzodiazepin-2-one,7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl- (7CI,8CI); 4'-Chlorodiazepam;7-Chloro-1-methyl-5-(p-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one;7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;Chlordiazepam; Ro 05-4864; Ro 5-4864 |
| Density: | 1.35g/cm3 |
| Melting Point: |
160-163 °C |
| Boiling Point: | 517.1°Cat760mmHg |
| Flash Point: | 266.6°C |
| Hazard Symbols: |
|
| Risk Codes: | 22 |
| Safety: | Mutation data reported. When heated to decomposition it emits toxic vapors of NOx and Cl−. |
| PSA: | 32.67000 |
| LogP: | 3.30780 |
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- 99833-82-6
N-<4-chloro-2-(4-chlorobenzoyl)phenyl>-N-methylchloroacetamide
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| With hexamethylenetetramine In methanol; water for 22h; Heating; | 94% |
- 99833-83-7
N-<4-chloro-2-(4-chlorobenzoyl)phenyl>-N-methylphthalimidoacetate
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| With hydrazine In methanol; water at 60℃; for 3h; | 80% |
- 5571-60-8
7-chloro-5-(4-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- 74-88-4
methyl iodide
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| With sodium methylate In toluene at 20℃; for 168h; | 37% |
- 724-07-2
3-(4-chlorobenzene)-5-chloro-2,1-benzoisoxazole
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux 2: 95 percent / CHCl3 / 8 h / Heating 3: 80 percent / N2H4 / methanol; H2O / 3 h / 60 °C View Scheme | |
| Multi-step reaction with 3 steps 1: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux 2: 86 percent / benzene / 1) 10 deg C, 50 min. (addition); 2) 90 min. 3: 94 percent / hexamethylenetetramine / methanol; H2O / 22 h / Heating View Scheme |
- 78961-59-8
5,4'-dichloro-2-methylaminobenzophenone
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 95 percent / CHCl3 / 8 h / Heating 2: 80 percent / N2H4 / methanol; H2O / 3 h / 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 86 percent / benzene / 1) 10 deg C, 50 min. (addition); 2) 90 min. 2: 94 percent / hexamethylenetetramine / methanol; H2O / 22 h / Heating View Scheme |
- 100-00-5
4-chlorobenzonitrile
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 43 percent / KOH / methanol; benzene / 3 h / Ambient temperature 2: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux 3: 95 percent / CHCl3 / 8 h / Heating 4: 80 percent / N2H4 / methanol; H2O / 3 h / 60 °C View Scheme | |
| Multi-step reaction with 4 steps 1: 43 percent / KOH / methanol; benzene / 3 h / Ambient temperature 2: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux 3: 86 percent / benzene / 1) 10 deg C, 50 min. (addition); 2) 90 min. 4: 94 percent / hexamethylenetetramine / methanol; H2O / 22 h / Heating View Scheme |
- 140-53-4
p-chlorobenzyl cyanide
- 14439-61-3
4-chlorodiazepam
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 43 percent / KOH / methanol; benzene / 3 h / Ambient temperature 2: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux 3: 95 percent / CHCl3 / 8 h / Heating 4: 80 percent / N2H4 / methanol; H2O / 3 h / 60 °C View Scheme | |
| Multi-step reaction with 4 steps 1: 43 percent / KOH / methanol; benzene / 3 h / Ambient temperature 2: 2) Fe, aq. HCl / 1) 5h, 80 deg C; 2) ethanol, water, 3 h, reflux 3: 86 percent / benzene / 1) 10 deg C, 50 min. (addition); 2) 90 min. 4: 94 percent / hexamethylenetetramine / methanol; H2O / 22 h / Heating View Scheme |
- Total:25 Page 1 of 1 1
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Chemistry
The Molecular formula of 4-Chlorodiazepam (CAS NO.14439-61-3):
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IUPAC: 7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Molecular formula:C16H12Cl2N2O
Formula Weight: 319.19 g/mol
CAS:14439-61-3
Index of Refraction: 1.647
Flash Point: 266.6 °C
Density: 1.35 g/cm3
Flash Point: 266.6 °C
Boiling Point: 517.1 °C at 760 mmHg
Toxicity Data With Reference
The toxicity of 4-Chlorodiazepam (CAS NO.14439-61-3):
Mutagenicity Data:
Test type:Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Cells - not otherwise specified
Dose/Time:10 nmol/L
Reference:CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990
Safety Profile
The Hazard Codes of 4-Chlorodiazepam (CAS NO.14439-61-3):
Xn
Risk Statements:R22:Harmful if swallowed.
Safety Statements:R22:Harmful if swallowed.
Mutation data reported. When heated to decomposition it emits toxic vapors of NOx and Cl−.