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146362-70-1

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Basic Information
CAS No.: 146362-70-1
Name: SR 48692
Article Data: 2
Molecular Structure:
Molecular Structure of 146362-70-1 (SR 48692)
Formula: C32H31 Cl N4 O5
Molecular Weight: 587.075
Synonyms: Meclinertant;SR 48692
Density: 1.5g/cm3
Boiling Point: 781.2°C at 760 mmHg
Flash Point: 426.2°C
PSA: 119.06000
LogP: 6.34220
Related products
Synthetic route
1443991-23-8

tert-butyl 2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylate

146362-70-1

merclinertant

Conditions
ConditionsYield
With QP-SA In dichloromethane at 18℃; for 20h;86%
With trifluoroacetic acid In dichloromethane at 35℃; for 3.5h;

ethyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutanoate

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation
2: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / Microwave irradiation
3: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C
4: QP-SA / dichloromethane / 20 h / 18 °C
View Scheme
1443991-22-7

ethyl 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / Microwave irradiation
2: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C
3: QP-SA / dichloromethane / 20 h / 18 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide; water / tetrahydrofuran
2: thionyl chloride / 3 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C
4: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C
View Scheme
42381-05-5

2-amino-2-adamantanecarboxylic acid

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: perchloric acid / water / 6 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C
3: QP-SA / dichloromethane / 20 h / 18 °C
View Scheme
703-23-1

2'-hydroxy-6'-methoxyacetophenone

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: methanol / 1 h / 160 °C
2: sodium ethanolate / ethanol / 0.42 h / 80 °C / Microwave irradiation
3: N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation
4: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / Microwave irradiation
5: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C
6: QP-SA / dichloromethane / 20 h / 18 °C
View Scheme
2040-04-2

2,6-dimethoxyacetophenone

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium ethanolate / ethanol / 0.42 h / 80 °C / Microwave irradiation
2: N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation
3: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / Microwave irradiation
4: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C
5: QP-SA / dichloromethane / 20 h / 18 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium / ethanol / 6 h / 20 °C
2: sulfuric acid / ethanol / 3 h / 20 - 100 °C / Microwave irradiation
3: sodium hydroxide; water / tetrahydrofuran
4: thionyl chloride / 3 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C
6: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C
View Scheme
1443991-26-1

1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

502937-07-7

2-amino-adamantane-2-carboxylic acid tert-butyl ester

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C
2: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C
View Scheme
700-58-3

2-Adamantanone

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: ammonia; ammonium chloride / ethanol; water / 8 h / 55 °C / pH > 10
2: potassium carbonate / tetrahydrofuran; water / 1.5 h / 20 °C
3: hydrogenchloride; water / tetrahydrofuran / 18 h / 20 °C
4: hydrogenchloride / water; acetic acid / 72 h / Reflux
5: tetrafluoroboric acid / water / 48 h / 60 °C / Sealed tube
6: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C
7: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C
View Scheme
24779-93-9

2-aminoadamantane-2-carbonitrile

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate / tetrahydrofuran; water / 1.5 h / 20 °C
2: hydrogenchloride; water / tetrahydrofuran / 18 h / 20 °C
3: hydrogenchloride / water; acetic acid / 72 h / Reflux
4: tetrafluoroboric acid / water / 48 h / 60 °C / Sealed tube
5: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C
6: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C
View Scheme
111697-02-0

2-benzamidoadamantane-2-carbonitrile

146362-70-1

merclinertant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride; water / tetrahydrofuran / 18 h / 20 °C
2: hydrogenchloride / water; acetic acid / 72 h / Reflux
3: tetrafluoroboric acid / water / 48 h / 60 °C / Sealed tube
4: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C
5: trifluoroacetic acid / dichloromethane / 3.5 h / 35 °C
View Scheme
Raw Materials
42381-05-5
700-58-3
703-23-1
2040-04-2
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