CAS No.14663-23-1,Dantrolene sodium salt Suppliers,MSDS download

Products Categories

Pharmaceutical (72)
Organic Chemicals (23)
Others (13)
Reagent (3)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	14663-23-1
Name:	Dantrolene sodium salt
Article Data:	1

Formula:	C₁₄H₉N₄O₅Na
Molecular Weight:	336.239
Synonyms:	2,4-Imidazolidinedione,1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt (9CI);Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-, sodium salt (8CI);Dantrium;Dantrolene sodium;F 440;Sodium dantrolene;
EINECS:	238-706-8
Boiling Point:	85°C 4mm
Flash Point:	283.1oC
Appearance:	COA
Safety:	22-24/25
PSA:	127.05000
LogP:	1.71410

Synthetic route

: 7261-97-4
dantrolene

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

Conditions

Conditions	Yield
With sodium methylate In methanol at 20℃; for 3h;	100%

: 7147-77-5
5-(4-nitrophenyl)-2-furaldehyde

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 81 percent / H2O; dimethylformamide 2: 100 percent / CH3ONa / methanol / 3 h / 20 °C View Scheme

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: 7261-97-4
dantrolene

Conditions

Conditions	Yield
With acetic acid In N,N-dimethyl-formamide at 20℃;	98%

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: 89151-46-2
tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate

: 3-{[(1-tert-butoxycarbonyl)piperidin-4-yl]ethyl}-1-{[5-(4-nitrophenyl)furfurylidene]amino}imidazolidine-2,4-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃;	96.4%

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: 145508-94-7
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate

: 3-{[(1-tert-butoxycarbonyl)piperidin-4-yl]methyl}-1-{[5-(4-nitrophenyl)furfurylidene]amino}imidazolidine-2,4-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃;	51.6%

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: C23H29N4O9P

Conditions

Conditions	Yield
With sodium iodide In N,N-dimethyl-formamide at 0 - 20℃; for 64h; Temperature;	45%

: 34573-36-9
N-[(1,1-dimethylethoxy)carbonyl]glycine chloromethyl ester

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: C22H23N5O9

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 110h;	27%

: 432037-43-9
tert-butyl chloromethyl butanedioate

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: C23H24N4O9

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 20h;	20%

: 3221-20-3
1-benzyl-4-(2-hydroxyethyl)piperazine

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: 3-[(4-benzylpiperizin-1-yl)ethyl]-1-{[5-(4-nitrophenyl)furfurylidene]amino}imidazolidine-2,4-dione

Conditions

Conditions	Yield
Stage #1: 1-benzyl-4-(2-hydroxyethyl)piperazine With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 0.333333h; Mitsunobu Displacement; Stage #2: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt In tetrahydrofuran at 60℃;	5.7%

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

: 540-51-2
2-bromoethanol

: (2-(2-hydroxyethoxy)-1-(((5-(4-nitrophenyl)furan-2-yl)methylene)amino)-1,5-dihydro-4H-imidazole-4-one)

Conditions

Conditions	Yield
Stage #1: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt With potassium carbonate In tetrahydrofuran; water for 0.5h; Stage #2: 2-bromoethanol In tetrahydrofuran; water at 20℃; for 24h;

Total:92 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 14663-23-1

Chemistry

Molecular Structure of Dantrolene sodium salt (CAS NO.14663-23-1):

IUPAC Name: Sodium 3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-5-oxo-4H-imidazol-2-olate
Molecular Formula: C₁₄H₉N₄O₅Na
Molecular Weight: 336.26g/mol
EINECS: 238-706-8
Boiling Point: 544.5 °C at 760 mmHg
Flash Point: 283.1 °C
Properties: solid
Freely Rotating Bonds: 4
Polar Surface Area: 124.22 Å²
Polarizability: 10^-24 cm³
Enthalpy of Vaporization: 86.63 kJ/mol
Vapour Pressure: 1.09E-12 mmHg at 25°C
InChI
InChI=1/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
Smiles
N1(CC([NH-]C1=O)=O)\N=C\c1oc(cc1)c1ccc(cc1)[N+](=O)[O-].[Na+]
The chemical synonyms of Dantrolene sodium salt (CAS NO.14663-23-1) are Sodium dantrolene ; Dantrium ; Dantrolene na ; Dantrolene sodium salt ; 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt ; 1-[[[5-(4-Nitrophenyl)-2-furanyl]-methylene]imino]2,4-imidazolidinedione sodium salt ; 1-[(5-[p-Nitrophenyl]furfurylidene)-amino]hydantoin sodium salt ; 1-((5-(p-Nitrophenyl)furfurylidene)amino)hydantoinsodium .
Product categories: Pharmacetical ; API's ; InsP3/Ryanodine receptor .The molecular structure of Dantrium

Toxicity Data With Reference

1.	orl-hmn TDLo:320 mg/kg:BAH,GIT	JAMAAP JAMA, Journal of the American Medical Association. 231 (1975),662.
2.	orl-wmn LDLo:600 mg/kg:GIT,SYS	NYSJAM New York State Journal of Medicine. 77 (1977),1759.
3.	orl-rat LD50:7431 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668.
4.	ipr-rat LD50:413 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668.
5.	orl-mus LD50:1188 mg/kg	JPMSAE Journal of Pharmaceutical Sciences. 69 (1980),327.
6.	ipr-mus LD50:534 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668.

Safety Profile

Moderately toxic by intraperitoneal and ingestion routes. Human systemic effects by ingestion: anorexia (human), hepatitis, nausea or vomiting, somnolence. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Na₂O.
Safety Statements: 22-24/25
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: MU3875000

Specification

In order to capture and identify key molecules that regulate the release of Ca(2+) from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, respectively, at the hydantoin moiety were found to have a highly selective inhibitory effect on physiological Ca(2+) release without affecting Ca(2+)-induced Ca(2+) release (CICR). Successful realization of the sharp discrimination between PCR and CICR has led to the creation of [(125)I]GIF-0082 and [(125)I]GIF-0276, which were synthesized by substituting a stannyl group with (125)I in the corresponding phenylstannane precursors. It is a muscle relaxation drug for treatment of diseases associated with spastic paralysis.