CAS No.146665-77-2,Eptaplatin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	146665-77-2
Name:	Eptaplatin

Formula:	C₁₁H₂₀N₂O₆Pt
Molecular Weight:	471.37
Synonyms:	Platinum,[2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-kN4,kN5][propanedioato(2-)-kO1,kO3]-,[SP-4-2-[4R-(2a,4a,5b)]]-;Heptaplatin;Platinum,[2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N'][propanedioato(2-)-O,O']-,[SP-4-2-[4R-(2a,4a,5b)]]-;SKI 2053R;
Melting Point:	43-49 °C
Boiling Point:	261.5 °C at 760 mmHg
Flash Point:	114 °C
Appearance:	white crystalline powder

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Chemistry

IUPAC Name: [(4R,5R)-5-(Aminomethyl)-2-propan-2-yl-1,3-dioxolan-4-yl]methanamine ; Platinum(2+) ; Propanedioate
Following is the structure of Eptaplatin (CAS NO.146665-77-2):

Empirical Formula: C₁₁H₂₀N₂O₆Pt
Molecular Weight: 471.3703
Flash Point: 114 °C
Melting point: 43-49 °C
Boiling Point: 261.5 °C at 760 mmHg
Enthalpy of Vaporization: 49.92 kJ/mol
Vapour Pressure: 0.0115 mmHg at 25 °C
Appearance of Eptaplatin (CAS NO.146665-77-2): White Crystalline Powder
Product Categories: Heterocyclic Compounds; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Canonical SMILES: CC(C)C1OC(C(O1)CN)CN.C(C(=O)[O-])C(=O)[O-].[Pt+2]
Isomeric SMILES: CC(C)C1O[C@@H]([C@H](O1)CN)CN.C(C(=O)[O-])C(=O)[O-].[Pt+2]
InChI: InChI=1S/C8H18N2O2.C3H4O4.Pt/c1-5(2)8-11-6(3-9)7(4-10)12-8;4-2(5)1-3(6)7;/h5-8H,3-4,9-10H2,1-2H3;1H2,(H,4,5)(H,6,7);/q;;+2/p-2/t6-,7-;;/m1../s1
InChIKey: XJXKGUZINMNEDK-GPJOBVNKSA-L

Uses

Eptaplatin (CAS NO.146665-77-2) is a coordination compound for treatment of cervix cancer.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	198mg/kg (198mg/kg)	Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.
mouse	LD50	oral	1590mg/kg (1590mg/kg)	Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.
rat	LD50	intraperitoneal	182mg/kg (182mg/kg)	Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.
rat	LDLo	oral	2gm/kg (2000mg/kg)	Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.

Specification

Eptaplatin , its cas register number 146665-77-2. It also can be called Heptaplatin ; [SP-4-2-[4R-(2a,4a,5b)]]-[2-(1-Methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N'][propanedioato(2-)-O,O']-platinum ; [Malonato(2-)-kappa~2~O~1~,O~3~]platinum - [(4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl]dimethanamine (1:1) ; cis-((4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N')(malonato(2-)-O,O')platinum ; and cis-Malonato((4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane)platinum(II) . Its classification code are Drug / Therapeutic Agent and Reproductive Effect.