Products Categories
CAS No.: | 14667-47-1 |
---|---|
Name: | Methyl 2-aminonicotinate |
Article Data: | 31 |
Molecular Structure: | |
Formula: | C7H8N2O2 |
Molecular Weight: | 152.153 |
Synonyms: | Nicotinicacid, 2-amino-, methyl ester (7CI,8CI);2-Amino-3-methoxycarbonylpyridine;2-Amino-3-pyridinecarboxylic acid methyl ester;2-Aminonicotinic acid methylester;Methyl 2-amino-3-pyridinecarboxylate;NSC522516; |
EINECS: | 681-092-5 |
Density: | 1.238 g/cm3 |
Melting Point: | 84-86 °C |
Boiling Point: | 251.3 °C at 760 mmHg |
Flash Point: | 105.8 °C |
Hazard Symbols: | Xn |
Risk Codes: | 20/21/22-36/37/38 |
Safety: | 22-26-36/37/39 |
PSA: | 65.21000 |
LogP: | 1.03160 |
2-aminopyridin-3-carboxylic acid
diazomethyl-trimethyl-silane
methyl 2-aminonicotinate
Conditions | Yield |
---|---|
In methanol; toluene at 0℃; for 0.5h; | 95% |
In methanol; diethyl ether; toluene at 0℃; for 0.75h; Inert atmosphere; | 90% |
In methanol; hexane for 0.5h; |
2-aminopyridin-3-carboxylic acid
methyl 2-aminonicotinate
Conditions | Yield |
---|---|
With triethylamine In methanol at 20℃; for 1h; | 94% |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 60℃; under 760.051 Torr; for 1.5h; Inert atmosphere; Microwave irradiation; | 93% |
With thionyl chloride at 0 - 80℃; for 3h; | 86% |
With sulfuric acid at 80℃; for 7h; | 63% |
2-aminopyridin-3-carboxylic acid
2-chloro-1,3-dimethylimidazolinium chloride
methyl 2-aminonicotinate
Conditions | Yield |
---|---|
With triethylamine In methanol for 1h; Ambient temperature; | 84% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; for 18h; Reflux; | 71% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Reflux; | 58% |
Stage #1: 2-aminopyridin-3-carboxylic acid With potassium carbonate In N,N-dimethyl-formamide Reflux; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 18h; Reflux; | 58% |
With potassium carbonate In N,N-dimethyl-formamide for 18h; | 3.2 g |
diazomethane
2-aminopyridin-3-carboxylic acid
methyl 2-aminonicotinate
Conditions | Yield |
---|---|
In methanol; diethyl ether at 0℃; |
3-amino-pyridine-2-carboxylic acid
diazomethyl-trimethyl-silane
methyl 2-aminonicotinate
Conditions | Yield |
---|---|
With methanol In diethyl ether; toluene at 20℃; Inert atmosphere; |
methyl 2-aminonicotinate
Conditions | Yield |
---|---|
With dodecacarbonyl-triangulo-triruthenium; 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane; isopropyl alcohol at 140℃; for 24h; Inert atmosphere; Sealed tube; | 70 %Spectr. |
methyl 2-aminonicotinate
2-amino-5-bromonicotinic acid ethyl ester
Conditions | Yield |
---|---|
With bromine; sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 1h; | 99% |
methyl 2-aminonicotinate
methyl 2-amino-5-bromopyridine-3-carboxylate
Conditions | Yield |
---|---|
With bromine; sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 1h; | 99% |
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 2h; | 77% |
What can I do for you?
Get Best Price
The 3-Pyridinecarboxylicacid, 2-amino-, methyl ester, with the CAS registry number 14667-47-1, has the systematic name and IUPAC name of methyl 2-aminopyridine-3-carboxylate. And the molecular formula of this chemical is C7H8N2O2. It belongs to the following product categories: Pharmacetical; Pyridine series; API intermediates; Pyridine.
The physical properties of 3-Pyridinecarboxylicacid, 2-amino-, methyl ester are as following: (1)ACD/LogP: 1.90; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.83; (4)ACD/LogD (pH 7.4): 1.9; (5)ACD/BCF (pH 5.5): 14.05; (6)ACD/BCF (pH 7.4): 16.26; (7)ACD/KOC (pH 5.5): 221.18; (8)ACD/KOC (pH 7.4): 256.07; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 42.43 Å2; (13)Index of Refraction: 1.57; (14)Molar Refractivity: 40.35 cm3; (15)Molar Volume: 122.8 cm3; (16)Polarizability: 15.99×10-24cm3; (17)Surface Tension: 53.4 dyne/cm; (18)Density: 1.238 g/cm3; (19)Flash Point: 105.8 °C; (20)Enthalpy of Vaporization: 48.86 kJ/mol; (21)Boiling Point: 251.3 °C at 760 mmHg; (22)Vapour Pressure: 0.0206 mmHg at 25°C.
You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, it is also harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Do not breathe dust; Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OC)c1cccnc1N
(2)InChI: InChI=1/C7H8N2O2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3,(H2,8,9)
(3)InChIKey: NZZDEODTCXHCRS-UHFFFAOYAY