CAS No.147403-03-0,Azilsartan Suppliers

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Basic Information

Molecular Structure:
CAS No.:	147403-03-0
Name:	Azilsartan
Article Data:	35

Formula:	C₂₅H₂₀N₄O₅
Molecular Weight:	456.458
Synonyms:	see 1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol- 3-yl)[1,1'-biphenyl]-4-yl]methyl]-2- ethoxy-;TAK 536;2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid;
EINECS:	808-058-6
Density:	1.42 cm³
Melting Point:	188 °C(dec.)
PSA:	123.24000
LogP:	4.19180

Synthetic route

: 1403474-70-3
ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide at 50℃; for 4h;	98.5%
With sodium hydroxide In water at 70 - 75℃; for 1.5h; Temperature;	93.4%
With pyrographite; sodium hydroxide In water at 55℃; for 2h; Temperature;	91%

: C25H19N4O5(1-)*Na(1+)

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;	97.1%

: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Stage #1: methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate With water; sodium hydroxide In methanol at 20℃; for 24h; Stage #2: With hydrogenchloride In water Product distribution / selectivity;	96.4%
With sodium hydroxide In methanol; water at 20℃; for 24h;	96%
With sodium hydroxide In water at 60 - 65℃; Temperature;	96.8%

: C25H19N4O5(1-)*K(1+)

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;	96.7%

0.36N-NaOH: 0.36N-NaOH

: 7440-44-0
pyrographite

: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
	96%

...Expand

0.40N-NaOH: 0.40N-NaOH

: 7440-44-0
pyrographite

: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
	96%

...Expand

: C25H19N4O5(1-)*Li(1+)

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;	95.8%

: 863031-21-4
Azilsartan medoxomil

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide at 75℃; for 1h; Temperature; Reagent/catalyst;	94.84%
With Bis(p-nitrophenyl) phosphate In acetonitrile at 37℃; for 0.0833333h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 2-ethoxy-1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid ethyl ester di-n-butylamine

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide In ethanol at 45 - 56℃; for 2.5h;	93%

: C28H28N4O5

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 40 - 50℃; for 1h; Reagent/catalyst;	92.8%

Raw Materials

541-41-3

616-38-6

Downstream Products

863031-21-4

Total:215 Page 1 of 6 1 2 3 4 5 6 Next>>

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Specification

The IUPAC name of Azilsartan is 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid. With the CAS registry number 147403-03-0, it is also named as 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid. The product's classification code is treatment of hypertension. Moreover, its molecular formula is C₂₅H₂₀N₄O₅and its molecular weight is 456.45.

The other characteristics of Azilsartan can be summarized as: (1)XLogP3-AA: 4.4; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 7; (4)Rotatable Bond Count: 7; (5)Tautomer Count: 3; (6)Exact Mass: 456.14337; (7)MonoIsotopic Mass: 456.14337; (8)Topological Polar Surface Area: 115; (9)Heavy Atom Count: 34; (10)Complexity: 783; (11)Density: 1.42 cm³.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)O
(2)InChI: InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
(3)InChIKey: KGSXMPPBFPAXLY-UHFFFAOYSA-N