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| CAS No.: | 1492-18-8 |
|---|---|
| Name: | Calcium folinate |
| Molecular Structure: | |
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| Formula: | C20H21N7O7.Ca |
| Molecular Weight: | 511.507 |
| Synonyms: | Calcium leucovorin;Calcium folinate ;Calcium leucovorin;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]-5,5-dihydroxy-pentanoic acid;Folinic acid-SF, calcium salt;L-Glutamic acid,N-[4-[[(2-amino-5-formyl- 1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)- methyl]amino]benzoyl]-,calcium salt (1:1);Uzel;Folinic acid calcium;Calcium Folinate(Leucovorin calcium);Calcium folinate anhydrous;Leucovorin Calcium; |
| EINECS: | 216-082-8 |
| Melting Point: | 240-250oC |
| Appearance: | Pale yellow crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 36/37/38-42/43 |
| Safety: | 26-36-36/37-22 |
| PSA: | 198.10000 |
| LogP: | 1.41100 |
(+/-)-L-5,6,7,8-Tetrahydrofolic acid calcium salt
| Conditions | Yield |
|---|---|
| In water at 100℃; for 11h; Yield given; |
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Chemical Name: Calcium folinate
IUPAC NAME: Calcium 2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
CAS No.: 1492-18-8
EINECS: 216-082-8
RTECS: MA0600500
RTECS Class: Drug
Molecular Formula: C20H21CaN7O7
Molecular Weight: 511.5 g/mol
Following is the structure of Folinic acid (CAS No.1492-18-8):
Product Categories: APIs ; Antitumors for Research and Experimental Use ; Biochemistry ; API's
The chemical synonymous of Folinic acid (CAS No.1492-18-8) are Calcium5-formyltetrahydrofolate ; Calciumsalt(1:1),l-yl)methyl)amino)benzoyl) ; Glutamicacid,n-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridin ; Lederfoline ; Leucovorincalciumsalt ; 5-Formlyl-5,6,7,8-tetrahydrofolic acid, calcium salt ; Leucovorin calcium
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1036mg/kg (1036mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. | |
| mouse | LD50 | intravenous | 732mg/kg (732mg/kg) | Drugs in Japan Vol. 6, Pg. 910, 1982. | |
| mouse | LD50 | oral | > 7gm/kg (7000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. | |
| rat | LD50 | intraperitoneal | 1063mg/kg (1063mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. | |
| rat | LD50 | oral | > 8gm/kg (8000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. |
Hazard Codes: 
Xn
Risk Statements about Folinic acid (CAS No.1492-18-8):
R42/43: May cause sensitization by inhalation and skin contact.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S36/37: Wear suitable protective clothing and gloves.
Attention:
1. Storage: Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 °C). Store protected from light and air.
2. Handling: Wash hands before eating. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Keep container tightly closed. Store protected from light. Use and store under nitrogen. Store and handle protected from air. Wash clothing before reuse. Discard contaminated shoes.
Folinic acid (CAS No.1492-18-8), generally administered as calcium folinate (or leucovorin calcium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate.It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.It is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M.It is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. In this case, folinic acid is not used for "rescue" purposes ; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase.
