Products Categories
CAS No.: | 149506-35-4 |
---|---|
Name: | 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER |
Article Data: | 14 |
Molecular Structure: | |
Formula: | C11H11 Br O4 |
Molecular Weight: | 287.11 |
Synonyms: | Propanedioicacid, (4-bromophenyl)-, dimethyl ester (9CI); 2-(4-Bromophenyl)malonic aciddimethyl ester; Dimethyl (4-bromophenyl)malonate |
Density: | 1.467±0.06 g/cm3(Predicted) |
Boiling Point: | 330.0±27.0 °C(Predicted) |
PSA: | 52.60000 |
LogP: | 1.87870 |
(4-bromo-phenyl)-acetic acid methyl ester
carbonic acid dimethyl ester
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 40 - 45℃; for 5h; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil at 20 - 32℃; for 24h; | 79% |
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil at 20℃; for 72h; | 77% |
In toluene; paraffin oil |
dimethyl diazomalonate
4-Bromophenylboronic acid
B
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
With (pentamethylcyclopentadienyl)*Rh(OAc)2; potassium carbonate; N-fluorobis(benzenesulfon)imide In N,N-dimethyl acetamide at 40℃; for 16h; Reagent/catalyst; Solvent; Temperature; | A 40% B 13% |
With (pentamethylcyclopentadienyl)*Rh(OAc)2; potassium acetate; N-fluorobis(benzenesulfon)imide In N,N-dimethyl acetamide at 80℃; for 16h; Solvent; Temperature; | A 17% B 21% |
(4-bromo-phenyl)-acetic acid methyl ester
methyl chloroformate
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
With lithium diisopropyl amide 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min; Yield given. Multistep reaction; |
2-(4-bromophenyl)acetyl chloride
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 2 h / Ambient temperature 2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min View Scheme |
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: SOCl2, DMF / CH2Cl2 / Ambient temperature 2: Et3N / CH2Cl2 / 2 h / Ambient temperature 3: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran / 1.83 h / 40 °C 2.2: 22 h / 20 - 31 °C 2.3: -10 °C / pH 6 - 7 View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / 3 h / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C 2.2: 24 h / 20 - 32 °C View Scheme |
carbonic acid dimethyl ester
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran at 27℃; for 1.83333h; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran at 20 - 31℃; for 22h; |
formamidine hydrochloride
2-(4-bromophenyl)-malonic acid dimethyl ester
5-(4-bromophenyl)-4,6-dihydroxypyrimidine
Conditions | Yield |
---|---|
at 25℃; for 16h; Temperature; | 92.6% |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; | 91% |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium methylate In methanol at 0℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; | |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; Stage #3: With citric acid In water | |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; Stage #3: With citric acid In water for 0.166667h; |
formamide
2-(4-bromophenyl)-malonic acid dimethyl ester
5-(4-bromophenyl)-4,6-dihydroxypyrimidine
Conditions | Yield |
---|---|
With sodium methylate In methanol at 70℃; | 75.25% |
2-(4-bromophenyl)-malonic acid dimethyl ester
methyl iodide
Conditions | Yield |
---|---|
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 2h; | 67% |
acrylic acid methyl ester
2-(4-bromophenyl)-malonic acid dimethyl ester
methyl 4-(4'-bromophenyl)-4,4-dimethoxycarbonylbutanoate
Conditions | Yield |
---|---|
With sodium methylate In methanol for 6h; Ambient temperature; | 64% |