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| CAS No.: | 1505-95-9 |
|---|---|
| Name: | Naftypramide |
| Molecular Structure: | |
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| Formula: | C19H26 N2 O |
| Molecular Weight: | 298.428 |
| Synonyms: | 1-Naphthaleneacetamide,a-[2-(dimethylamino)ethyl]-a-isopropyl- (7CI,8CI); DA 992;Naftipramide; Naftypramide; Naphthipramide; Naphthypramide; a-Isopropyl-a-(2-dimethylaminoethyl)-1-naphthacetamide;a-Isopropyl-a-(2-dimethylaminoethyl)-1-naphthylacetamide;a-Isopropyl-a-[2-(dimethylamino)ethyl]-1-naphthaleneacetamide;a-Isopropyl-a-dimethylaminoethyl-1-naphthylacetamide;a-[2-(Dimethylamino)ethyl]-a-(1-methylethyl)-1-naphthaleneacetamide |
| Density: | 1.061g/cm3 |
| Boiling Point: | 482.6°Cat760mmHg |
| Flash Point: | 245.7°C |
| Safety: | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 46.33000 |
| LogP: | 3.87090 |
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Chemistry
Empirical Formula of Naftypramide (CAS NO.1505-95-9): C19H26N2O
Molecular Weight: 298.4225 g/mol
Index of Refraction: 1.574
Density: 1.061 g/cm3
Flash Point: 245.7 °C
Enthalpy of Vaporization: 74.75 kJ/mol
Boiling Point: 482.6 °C at 760 mmHg
Vapour Pressure: 1.8E-09 mmHg at 25 °C
Structure of Naftypramide (CAS NO.1505-95-9):
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IUPAC Name: 2-(2-Dimethylaminoethyl)-3-methyl-2-naphthalen-1-ylbutanamide
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | oral | > 500mg/kg (500mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 356, 1968. |
| mouse | LD50 | intravenous | 72mg/kg (72mg/kg) | Experientia. Vol. 20, Pg. 457, 1964. | |
| mouse | LD50 | oral | 1086mg/kg (1086mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 162, Pg. 378, 1966. | |
| mouse | LDLo | intraperitoneal | 250mg/kg (250mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Journal of Medicinal Chemistry. Vol. 8, Pg. 594, 1965. |
| rat | LD50 | intraperitoneal | 269mg/kg (269mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 162, Pg. 378, 1966. | |
| rat | LD50 | oral | 1030mg/kg (1030mg/kg) | Journal of Medicinal Chemistry. Vol. 16, Pg. 720, 1973. |
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition Naftypramide (CAS NO.1505-95-9) emits toxic fumes of NOx.
Specification
Naftypramide ,its cas register number is 1505-95-9. It also can be called 4-Dimethylamino-2-isopropyl-2-(1-naphtyl)butyramid ; and 1-Naphthaleneacetamide, alpha-(2-(dimethylamino)ethyl)-alpha-isopropyl- .