Products Categories
| CAS No.: | 152628-02-9 |
|---|---|
| Name: | 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole |
| Molecular Structure: | |
|
|
|
| Formula: | C19H20N4 |
| Molecular Weight: | 304.395 |
| Synonyms: | 1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole;4-Methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazole;1H-Benzimidazole-2-n-propyl-4-methyl-6-(1'-methylbenzimidazole-2'-yl); |
| EINECS: | 604-866-6 |
| Density: | 1.23 g/cm3 |
| Melting Point: | 130-135 °C(Solv: tetrahydrofuran (109-99-9)) |
| Boiling Point: | 584.802 °C at 760 mmHg |
| Flash Point: | 307.477 °C |
| Appearance: | grey powder |
| PSA: | 46.50000 |
| LogP: | 4.37750 |
N-methylbenzene-1,2-diamine dihydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With methanesulfonic acid In i-Amyl alcohol at 130 - 135℃; for 18h; Temperature; Solvent; Reagent/catalyst; | 93% |
| Stage #1: N-methylbenzene-1,2-diamine dihydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA at 70 - 135℃; for 13.5h; Stage #2: With ammonia In water at 30 - 90℃; for 1h; pH=8.0 - 8.5; | 77.4% |
| With PPA at 150℃; for 20h; | 5.86 g |
| With polyphosphoric acid at 150℃; for 14h; |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃; | 93% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃; | 92% |
N-methyl-1,2-phenylenediamine
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With methanesulfonic acid; phosphorus pentoxide at 75 - 145℃; Stage #2: With sodium hydroxide In water pH=< 3; Product distribution / selectivity; | 90% |
| With polyphosphoric acid at 150 - 155℃; for 4h; Inert atmosphere; | 80% |
| With PPA at 150 - 155℃; Inert atmosphere; | |
| Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid at 70 - 130℃; for 8.5h; Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.166667h; Stage #3: With ammonium hydroxide In methanol; water at 25℃; for 1h; Reagent/catalyst; |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water; acetonitrile at 20℃; | 90% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| Stage #1: 2-n-propyl-4-methyl-6-formylchlorobenzimidazole; N-methyl-o-phenylenediamine hydrochloride With triethylamine In dichloromethane at 40℃; for 3h; Large scale; Stage #2: With acetic acid In dichloromethane at 60℃; for 5h; Temperature; Reagent/catalyst; Solvent; Large scale; | 89.96% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With p-toluenesulfonyl chloride In water; acetonitrile at 0 - 20℃; | 88% |
| Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / 0 - 20 °C 2: sodium hydroxide / acetonitrile; water / 20 °C View Scheme |
2-methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrobenzenamine
butyraldehyde
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With sodium dithionite In methanol; water for 12h; Reflux; | 85% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| Stage #1: C19H21N3O*ClH With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide In acetonitrile at 80 - 85℃; for 2h; Stage #2: With hydroxylamine In acetonitrile at 20℃; for 1h; Stage #3: With triethylamine; p-toluenesulfonyl chloride at 0 - 20℃; | 85% |
| Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C 2: p-toluenesulfonyl chloride / acetonitrile; water / 0 - 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C 2: triethylamine / acetonitrile / 0 - 20 °C 3: sodium hydroxide / acetonitrile; water / 20 °C View Scheme |
N1-methylbenzene-1,2-diamine hydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
A
desmethyl dibenzimidazole
B
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
C
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
D
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
| Conditions | Yield |
|---|---|
| With polyphosphoric acid at 150 - 155℃; | A n/a B n/a C n/a D 84% |
What can I do for you?
Get Best Price
Molecular structure of 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole (CAS NO.152628-02-9) is:
Product Name: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
CAS Registry Number: 152628-02-9
Molecular Formula: C19H20N4
Molecular Weight: 304.39
Surface Tension: 45.191 dyne/cm
Density: 1.234 g/cm3
Flash Point: 307.477 °C
Enthalpy of Vaporization: 87.377 kJ/mol
Boiling Point: 584.802 °C at 760 mmHg
Product Categories: Chemical intermediate for Telmisartan;Intermediatesof;Imidazol&Benzimidazole;Imidazoles;(intermediate of telmisartan);Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical intermediates
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole , its cas register number is 152628-02-9. It also can be called 1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole .It is a grey powder.
