CAS No.153832-46-3,Ertapenem Suppliers

Products Categories

Pharmaceutical (122)
Organic Chemicals (23)
Others (21)
Reagent (3)
Materials (2)
(1)

Basic Information

Molecular Structure:
CAS No.:	153832-46-3
Name:	Ertapenem
Article Data:	3

Formula:	C₂₂H₂₅N₃O₇S
Molecular Weight:	475.522
Synonyms:	1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[[5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-,[4R-[3(3S,5S),4a,5b,6b(R*)]]-;UNII-G32F6EID2H;Invanz;
EINECS:	1533716-785-6
Density:	1.55 g/cm³
Boiling Point:	813.9 °C at 760 mmHg
Flash Point:	446 °C
PSA:	181.57000
LogP:	1.28040

Hot Products

Total:140 Page 1 of 4 1 2 3 4 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 153832-46-3

History

Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz. It is structurally very similar to meropenem in that it possess a 1-β-methyl group.

Specification

The Ertapenem , with cas registry number of 153832-46-3, belongs to the categories of pharmaceutical intermediates; anti-bacterial agents; anti-infective agents. It is also called (4R,5R,6S)-3-[(3S,5S)-5-[(3-Carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid . Its IUPAC name is called (4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid . The systematic name is (4R,5S,6S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid .

Physical properties of Ertapenem are: (1) ACD/LogP: -1.07 ; (2) # of Rule of 5 Violations: 2 ; (3) ACD/LogD (pH 5.5): -4.3 ; (4) ACD/LogD (pH 7.4): -4.66 ; (5) ACD/BCF (pH 5.5): 1 ; (6) ACD/BCF (pH 7.4): 1 ; (7) ACD/KOC (pH 5.5): 1 ; (8) ACD/KOC (pH 7.4): 1 ; (9) #H bond acceptors: 10 ; (10) #H bond donors: 5 ; (11) #Freely Rotating Bonds: 8 ; (12) Index of Refraction: 1.699 ; (13) Molar Refractivity: 118.29 cm³ ; (14) Molar Volume: 306.2 cm³ ; (15) Surface Tension: 84.8 dyne/cm ; (16) Density: 1.55 g/cm³ ; (17) Flash Point: 446 °C ; (18) Enthalpy of Vaporization: 124.04 kJ/mol ; (19) Boiling Point: 813.9 °C at 760 mmHg ; (20) Vapour Pressure: 5.26E-28 mmHg at 25°C.

Uses of Ertapenem : This product is a new carbapenem antibiotic. It can inhibit of bacterial growth and reproduction. The mechanism is that this compound can interfere with synthesis of bacterial cell wall by binding with penicillin-binding protein (PBP). But it can be hydrolyzed by metalloenzyme. It can be used for the treatment of moderate to severe infections including complicated intra-abdominal infection, complicated skin and soft tissue infections, community acquired pneumonia, complicated urinary tract infections, acute pelvic infection, and so on.

You can still convert the following datas into molecular structure:
(1) SMILES:O=C(O)c1cc(ccc1)NC(=O)[C@H]4NC[C@@H](S\C3=C(\N2C(=O)[C@H]([C@H](O)C)[C@H]2[C@H]3C)C(=O)O)C4;
(2) InChI:InChI=1/C22H25N3O7S/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32)/t9-,10-,13+,14+,15-,16-/m1/s1;
(3) InChIKey:JUZNIMUFDBIJCM-ANEDZVCMBR