CAS No.154-41-6,DL-Norephedrine hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	154-41-6
Name:	DL-Norephedrine hydrochloride
Article Data:	9

Formula:	C₉H₁₃NO^.HCl
Molecular Weight:	187.669
Synonyms:	Benzenemethanol, a-[(1R)-1-aminoethyl]-,hydrochloride, (aS)-rel-(9CI);Acutrim;Benzenemethanol, a-(1-aminoethyl)-, hydrochloride, (R,S)-;Dexatrim;Flurest;IP 58064;Mydriatin;NSC 23798;Norephedrine hydrochloride;Obestat;Permathene 16;Phenylpropanolaminehydrochloride;Propadrine hydrochloride;Thinz-Span;dl-Norephedrinehydrochloride;dl-Phenylpropanolamine hydrochloride;erythro-Norephedrinehydrochloride;
EINECS:	205-826-7
Density:	1.071g/cm³
Melting Point:	194-196 °C(lit.)
Boiling Point:	288.1 °C at 760 mmHg
Flash Point:	128.1 °C
Solubility:	>=10 g/100 mL at 21 C
Appearance:	white crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	22-36/37/39-45
Transport Information:	UN 2811
PSA:	46.25000
LogP:	2.56950

Raw Materials

119-51-7

100-52-7

Downstream Products

492-39-7

93-55-0

492-41-1

40626-29-7

37577-28-9

3198-15-0

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Chemistry

The Molecular formula of PROPADRINE HYDROCHLORIDE(154-41-6):C₉H₁₄ClNO
The Molecular Weight of PROPADRINE HYDROCHLORIDE(154-41-6):187.67
The Molecular Structure of PROPADRINE HYDROCHLORIDE(154-41-6) is:

Melting point:194-196 ^°C(lit.)
Boiling point:288.1 ^°C at 760 mmHg
Flash point:128.1 ^°C
Solubility in water:soluble
Merck:13,7391
Enthalpy of Vaporization:55.7 kJ/mol
Vapour Pressure:0.0011 mmHg at 25^°C
Appearance:odorless white to creamy-white crystalline powder.
IUPAC Name:2-amino-1-phenylpropan-1-ol hydrochloride
Synonyms::[R*,S*]-[+/-]-ALPHA-[AMINOETHYL]BENZENEMETHANOL HYDROCHLORIDE;NOREPHEDRINE HCL;[+/-]-NOREPHEDRINE HYDROCHLORIDE;NOREPHEDRINE HYDROCHLORIDE;PHENYLPROPANOLAMINE HCL;(+/-)-PHENYLPROPANOLAMINE HYDROCHLORIDE;PHENYLPROPANOLAMINE HYDROCHLORIDE;(+/-)-NOREPHEDRINE HYDROCHLORIDE
Reactivity Profile:DL-Norephedrine hydrochloride is incompatible with strong oxidizing agents.

Uses

This product is nasal decongestants, anorectics agent.

Toxicity Data With Reference

1.	orl-rat LD50:1490 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185.
2.	ipr-rat LD50:160 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 86 (1946),284.
3.	scu-rat LDLo:80 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 71 (1941),62.
4.	orl-mus LD50:150 mg/kg	THERAP Therapie. 20 (1965),297.
5.	ipr-mus LD50:428 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 92 (1948),207.
6.	scu-mus LD50:600 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 86 (1946),280.
7.	ivn-mus LDLo:275 mg/kg	QJPPAL Quarterly Journal of Pharmacy and Pharmacology. 9 (1936),203.
8.	scu-rbt LD50:255 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 86 (1946),284.
9.	ivn-rbt LD50:50 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 86 (1946),284.
10.	ims-rbt LD50:320 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 86 (1946)

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of HCl and NO_x. Used as a raw material in cold and diet tablets.
Hazard Codes:Xn
Xn:Harmful
Risk Statements
Harmful if swallowed.
Safety Statements
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR:UN 2811
WGK Germany:3
RTECS:DN4200000