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CAS No.: | 15401-69-1 |
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Name: | berberrubine |
Article Data: | 80 |
Molecular Structure: | |
Formula: | C19H16 N O4 . Cl |
Molecular Weight: | 357.793 |
Synonyms: | Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9-hydroxy-10-methoxy-, chloride (9CI); Berbinium,7,8,13,13a-tetradehydro-9-hydroxy-10-methoxy-2,3-(methylenedioxy)-, chloride(8CI); 9-Berberoline chloride; 9-Demethoxy-9-hydroxyberberinium chloride;Berberrubine chloride; Beroline chloride |
Density: | g/cm3 |
Melting Point: | 245℃ (DEC.) |
Boiling Point: | °Cat760mmHg |
Flash Point: | °C |
PSA: | 51.80000 |
LogP: | -0.20270 |
berberrubine
berberrubine chloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 20℃; for 8h; | 98% |
With hydrogenchloride In chloroform Ambient temperature; | 94.1% |
With hydrogenchloride In ethanol; water pH=5 - 6; | 82% |
With hydrogenchloride In water | |
With hydrogenchloride In ethanol at 20℃; |
berberine chloride
berberrubine chloride
Conditions | Yield |
---|---|
at 180℃; for 0.333333h; | 98% |
In N,N-dimethyl-formamide at 160℃; | 94% |
at 190℃; for 0.333333h; | 93.92% |
berberrubine
berberrubine chloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetonitrile at 20℃; for 3h; | 90% |
berberine chloride hydrate
berberrubine chloride
Conditions | Yield |
---|---|
at 190℃; under 20 - 30 Torr; for 2h; Calcination; | 80% |
berberrubine chloride
Conditions | Yield |
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With sulfide ion In aq. buffer pH=7.2; |
berberrubine chloride
Conditions | Yield |
---|---|
With hydrogenchloride In water Cooling; | |
With hydrogenchloride In water |
3-methoxy-2-hydroxybenzaldehyde
berberrubine chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 0.5 h / 70 - 95 °C / 712.57 Torr / Autoclave 2.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 3.1: hydrogenchloride / water / Cooling 3.2: 2 h / 85 - 120 °C 3.3: 0.67 h / 85 - 90 °C 4.1: hydrogenchloride / water / Cooling View Scheme | |
Multi-step reaction with 4 steps 1.1: 70 - 95 °C / Autoclave 2.1: hydrogen / 0.83 h / 70 - 115 °C / Autoclave; High pressure 3.1: hydrogenchloride / water / 70 - 90 °C 3.2: 2 h / 85 - 120 °C 3.3: 85 °C 4.1: hydrogenchloride / water View Scheme | |
Multi-step reaction with 4 steps 1.1: 0.5 h / 70 - 95 °C / 712.57 Torr / Autoclave 2.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 3.1: hydrogenchloride / 20 °C 4.1: copper dichloride / 2 h / 85 - 120 °C 4.2: 0.67 h / 85 °C View Scheme |
3,4-methylenedioxyphenylethylamine
berberrubine chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 0.5 h / 70 - 95 °C / 712.57 Torr / Autoclave 2.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 3.1: hydrogenchloride / water / Cooling 3.2: 2 h / 85 - 120 °C 3.3: 0.67 h / 85 - 90 °C 4.1: hydrogenchloride / water / Cooling View Scheme | |
Multi-step reaction with 4 steps 1.1: 70 - 95 °C / Autoclave 2.1: hydrogen / 0.83 h / 70 - 115 °C / Autoclave; High pressure 3.1: hydrogenchloride / water / 70 - 90 °C 3.2: 2 h / 85 - 120 °C 3.3: 85 °C 4.1: hydrogenchloride / water View Scheme | |
Multi-step reaction with 4 steps 1.1: 0.5 h / 70 - 95 °C / 712.57 Torr / Autoclave 2.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 3.1: hydrogenchloride / 20 °C 4.1: copper dichloride / 2 h / 85 - 120 °C 4.2: 0.67 h / 85 °C View Scheme |
2-{[(E)-2-Benzo[1,3]dioxol-5-yl-ethylimino]-methyl}-6-methoxy-phenol
berberrubine chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 2.1: hydrogenchloride / water / Cooling 2.2: 2 h / 85 - 120 °C 2.3: 0.67 h / 85 - 90 °C 3.1: hydrogenchloride / water / Cooling View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 0.83 h / 70 - 115 °C / Autoclave; High pressure 2.1: hydrogenchloride / water / 70 - 90 °C 2.2: 2 h / 85 - 120 °C 2.3: 85 °C 3.1: hydrogenchloride / water View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 2.1: hydrogenchloride / 20 °C 3.1: copper dichloride / 2 h / 85 - 120 °C 3.2: 0.67 h / 85 °C View Scheme |
Methylenedioxybenzene
berberrubine chloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: ethyl acetate / 8 h 2.1: 70 - 95 °C / Autoclave 3.1: hydrogen / 0.83 h / 70 - 115 °C / Autoclave; High pressure 4.1: hydrogenchloride / water / 70 - 90 °C 4.2: 2 h / 85 - 120 °C 4.3: 85 °C 5.1: hydrogenchloride / water View Scheme | |
Multi-step reaction with 5 steps 1.1: ethyl acetate / 8 h 2.1: 0.5 h / 70 - 95 °C / 712.57 Torr / Autoclave 3.1: hydrogen / 0.83 h / 70 - 115 °C / 22502.3 - 30003 Torr / Autoclave 4.1: hydrogenchloride / 20 °C 5.1: copper dichloride / 2 h / 85 - 120 °C 5.2: 0.67 h / 85 °C View Scheme |