Welcome to LookChem.com Sign In|Join Free

Home > Pharmaceutical > 155396 >

155396-69-3

Products Categories

Pharmaceutical (32)
Others (4)
Organic Chemicals (4)

Basic Information

Molecular Structure:
CAS No.:	155396-69-3
Name:	(2R,4S,5R)-3-(tert-butoxycarbonyl)-2-(4-Methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid
Article Data:	3

Formula:	C₂₂H₂₅NO₆
Molecular Weight:	399.444
Synonyms:	(2R,4S,5R)-3-t-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid;(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid;(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid;
EINECS:	605-008-3
Density:	1.238g/cm³
Boiling Point:	573.799°C at 760 mmHg
Flash Point:	300.823°C
PSA:	85.30000
LogP:	4.09350

Synthetic route

: 155396-68-2
(2R,4S,5R)-5-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-2-(4-methoxy-phenyl)-4-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h;	100%

: 153652-73-4
(2R,4S,5R)-3-t-butoxycarbonyl-4-phenyl-2-(4-methoxyphenyl)-5-methoxycarbonyl-1,3-oxazolidine

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
With KOH (or LiOH*H2O) In methanol; water Yield given;

: 4248-19-5
tert-butyl carbamate

ammonium salt of/the/ tert-butylsulfuric acid: ammonium salt of/the/ tert-butylsulfuric acid

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 5 steps 1: 68 percent / HCOOH / methanol; H2O / 21 h / 20 °C 2: 100 percent / K2CO3 / tetrahydrofuran / 12 h / Heating 3: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 4: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 5: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 100-52-7
benzaldehyde

sodium cyanate: sodium cyanate

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 5 steps 1: 68 percent / HCOOH / methanol; H2O / 21 h / 20 °C 2: 100 percent / K2CO3 / tetrahydrofuran / 12 h / Heating 3: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 4: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 5: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 150884-50-7
benzaldehyde N-boc imine

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 2: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 3: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 155396-71-7
tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / K2CO3 / tetrahydrofuran / 12 h / Heating 2: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 3: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 4: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 155396-67-1
[(1S,2R)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-(4-methoxy-benzyloxy)-3-oxo-1-phenyl-propyl]-carbamic acid tert-butyl ester

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 2: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 2-(4'-methoxybenzyloxy)acetyl chloride

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 4 steps 1: 86 percent / NaH / toluene / 1.) 20 deg C, 30 min, 2.) 20 deg C, 3 h 2: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 3: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 4: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 155396-70-6
N-<<(p-Methoxybenzyl)oxy>acetyl>-2,10-camphorsultam

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 2: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 3: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 155396-69-3
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Conditions	Yield
Multi-step reaction with 2 steps 1: 74 percent / PPTS / toluene / 0.5 h / Heating 2: KOH (or LiOH*H2O) / methanol; H2O View Scheme

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer