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CAS No.: | 15579-15-4 |
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Name: | 1H-Indazol-5-ol |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C7H6N2O |
Molecular Weight: | 134.137 |
Synonyms: | 5-Indazolol(5CI);5-Hydroxy-1H-indazole;5-Hydroxyindazole;NSC 520104; |
Density: | 1.434 g/cm3 |
Melting Point: | 186-191°C |
Boiling Point: | 366.5 °C at 760 mmHg |
Flash Point: | 175.5 °C |
Hazard Symbols: | Xi |
Risk Codes: | 22-41 |
Safety: | 26-39 |
PSA: | 48.91000 |
LogP: | 1.26850 |
5-methoxy-1H-indazole
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
With boron tribromide In dichloromethane at 20℃; for 10h; | 71% |
1H-indazol-5-ylamine
5-hydroxy-1H-indazole
Conditions | Yield |
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With sulfuric acid at 170 - 180℃; | |
With sulfuric acid at 200 - 205℃; unter Druck; | |
Stage #1: 1H-indazol-5-ylamine With sulfuric acid In water at 180℃; for 15h; Stage #2: With sodium hydroxide In water pH=> 10; |
N,O-diacetyl-5-hydroxy-1H-indazole
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 80℃; for 5h; | 7.99 g |
4-amino-3-methylphenol
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium acetate; isoamyl nitrite / CHCl3 / 18 h / 80 °C 2: 7.99 g / HCl / methanol / 5 h / 80 °C View Scheme |
5-nitroindazole
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Raney nickel / Hydrogenation 2: aqueous H2SO4 / 170 - 180 °C View Scheme |
isopentyl nitrate
4-amino-3-methylphenol
sodium hydrogencarbonate
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
With potassium acetate; acetic anhydride In hydrochloric acid-methanol; water; chlorobenzene |
2-methyl-4-methoxyaniline
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sodium nitrite / water / 20 °C 2: boron tribromide / dichloromethane / 10 h / 20 °C View Scheme |
5-hydroxy-1H-indazole
tert-butyldimethylsilyl chloride
5-(tert-butyl-dimethyl-silanyloxy)-1H-indazole
Conditions | Yield |
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With 1H-imidazole In N,N-dimethyl-formamide at 0 - 18℃; for 3.5h; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 18℃; for 3.5h; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 18h; | 99% |
Conditions | Yield |
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Stage #1: 5-hydroxy-1H-indazole; ethyl bromoacetate With potassium carbonate In acetone for 16h; Inert atmosphere; Reflux; Stage #2: With sodium hydroxide In methanol at 20℃; for 3h; Inert atmosphere; | 99% |
5-hydroxy-1H-indazole
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrahydrofuran at 20℃; for 14h; | 91% |
With N-Bromosuccinimide In tetrahydrofuran at 25℃; for 12h; | 90% |
IUPAC Name: 1H-indazol-5-ol
Synonyms of 1H-Indazol-5-ol (CAS NO.15579-15-4): 5-Hydroxy indazole ; Hydroxy-5 indazole
Product Categories: Alcohols and Derivatives;Heterocycles;pharmacetical
CAS NO: 15579-15-4
Molecular Formula: C7H6N2O
Molecular Weight : 134.135340 g/mol
Molecular Structure:
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 27.05Å2
Index of Refraction: 1.76
Molar Refractivity: 38.5 cm3
Molar Volume: 93.5 cm3
Surface Tension: 80.1 dyne/cm
Density: 1.434 g/cm3
Flash Point: 175.5 °C
Enthalpy of Vaporization: 63.7 kJ/mol
Boiling Point: 366.5 °C at 760 mmHg
Vapour Pressure: 6.9E-06 mmHg at 25°C
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | oral | 1gm/kg (1000mg/kg) | French Medicament Patent Document. Vol. #7631M, |
Hazard Cods: Xi
Hazard Note: Irritant