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1563-66-2

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Basic Information
CAS No.: 1563-66-2
Name: Carbofuran
Article Data: 16
Molecular Structure:
Molecular Structure of 1563-66-2 (Carbofuran)
Formula: C12H15NO3
Molecular Weight: 221.256
Synonyms: EPA Pesticide Chemical Code 090601;Chinufur;2,3-Dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate;OMS-864;BAY 70143;Curaterr;D 1221;Carbofurane;Kenofuran;C2292-59A;Niagara 10242;Furodan;Niagara nia-10242;FMC 10242;Crisfuran;Brifur;(2,2-dimethyl-3H-benzofuran-7-yl) N-methylcarbamate;
EINECS: 216-353-0
Density: 1.137 g/cm3
Melting Point: 150-153 °C(lit.)
Boiling Point: 313.3 °C at 760 mmHg
Flash Point: 143.3 °C
Solubility: Slightly soluble: 0.07 g/100 mL
Appearance: odorless white crystalline solid
Hazard Symbols: VeryT+,DangerousN,ToxicT
Risk Codes: 26/28-50/53
Safety: 36/37-45-60-61-1/2
Transport Information: UN 2811 6.1/PG 1
PSA: 47.56000
LogP: 2.50920
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    Carbofuran

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Chemistry

Molecular Structure:

Molecular Formula: C12H15NO3
Molecular Weight: 221.2524
IUPAC Name: (2,2-Dimethyl-3H-1-benzofuran-7-yl) N-methylcarbamate
Synonyms of Carbofuran (CAS NO.1563-66-2): 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, 7-(N-methylcarbamate) ; 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate ; Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester ; Furadan ; Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
CAS NO: 1563-66-2
Product Categories: Acaricide ; Agricultural Chemical ; Anthelmintics ; Anti-Infective Agents ; Antinematodal agents ; Antiparasitic Agents ; Avicide ; Cholinergic Agents ; Cholinesterase inhibitors ; Enzyme Inhibitors ; Human Data ; Insecticide ; Insecticides ; Mutation data ; Nematocide ; Neurotransmitter Agents ; Pesticides ; Reproductive Effect
Melting point: 150-153 °C 
Index of Refraction: 1.525
Molar Refractivity: 59.67 cm3
Molar Volume: 194.4 cm3
Surface Tension: 40.5 dyne/cm
Density: 1.137 g/cm3
Flash Point: 143.3 °C
Enthalpy of Vaporization: 55.43 kJ/mol
Boiling Point: 313.3 °C at 760 mmHg
Vapour Pressure: 0.000502 mmHg at 25°C

History

 Carbofuran (CAS NO.1563-66-2) is one of the few insecticides effective on soybean aphids, which have expanded their range since 2002 to include most soybean-growing regions of the U.S.
 

Uses

 Carbofuran (CAS NO.1563-66-2) is used as a systemic insecticide to control insects in a wide variety of field crops.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 420ug/kg (0.42mg/kg)   Toxicology and Applied Pharmacology. Vol. 26, Pg. 154, 1973.
bird - wild LD50 skin 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 26, Pg. 154, 1973.
chicken LD50 oral 6300ug/kg (6.3mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
dog LC50 inhalation 52mg/m3 (52mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
JOM, Journal of Occupational Medicine. Vol. 12, Pg. 16, 1970.
dog LD50 oral 19mg/kg (19mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
JOM, Journal of Occupational Medicine. Vol. 12, Pg. 16, 1970.
duck LD50 oral 415ug/kg (0.415mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 556, 1972.
guinea pig LC50 inhalation 43mg/m3/4H (43mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. N5182, Pg. 1967,
mammal (species unspecified) LD50 skin 837mg/kg (837mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(2), Pg. 89, 1988.
mouse LD50 intravenous 450ug/kg (0.45mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#11280,
mouse LD50 oral 2mg/kg (2mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 18, Pg. 793, 1970.
mouse LD50 unreported 5mg/kg (5mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(10), Pg. 23, 1984.
pigeon LD50 oral 1330ug/kg (1.33mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
quail LD50 oral 3160ug/kg (3.16mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
rabbit LD50 skin 885mg/kg (885mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 81, 1973.
rabbit LD50 unreported 885mg/kg (885mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 192, 1971.
rat LC50 inhalation 85mg/m3 (85mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
JOM, Journal of Occupational Medicine. Vol. 12, Pg. 16, 1970.
rat LD50 oral 5mg/kg (5mg/kg)   Pesticide Science. Vol. 1, Pg. 117, 1970.
rat LD50 skin 120mg/kg (120mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LD50 unreported 19mg/kg (19mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(10), Pg. 23, 1984.
women TDLo oral 1200ug/kg (1.2mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Khigiena i Zdraveopazvane. Hygiene and Sanitation. Vol. 24, Pg. 445, 1981.

Safety Profile

Hazard Codes of Carbofuran (CAS NO.1563-66-2): VeryT+,DangerousN,ToxicT
Risk Statements: 26/28-50/53 
R26/28: Very toxic by inhalation and if swallowed. 
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 36/37-45-60-61-1/2 
S36/37: Wear suitable protective clothing and gloves. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S60: This material and its container must be disposed of as hazardous waste. 
S61: Avoid release to the environment. Refer to special instructions / safety data sheets. 
S1/2: Keep locked up and out of the reach of children.
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: FB9450000
HazardClass: 6.1(a)
PackingGroup: I

Specification

The technical or chemical name of Carbofuran is 2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate and its CAS number is 1563-66-2 and it is manufactured by reaction of Methyl isocyanate with 2,3-dihydro-2,2-dimethyl-7-hydroxybenzofuran.