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CAS No.: | 157356-73-5 |
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Name: | 4-(1-Methylethenyl)-2-propyl-1H-Imidazole-5-carboxylic acidethylester |
Article Data: | 1 |
Molecular Structure: | |
Formula: | C12H18N2O2 |
Molecular Weight: | 222.287 |
Synonyms: | 4-(1-Methylethenyl)-2-propyl-1H-Imidazole-5-carboxylic acidethylester |
Density: | 1.055±0.06 g/cm3(Predicted) |
Boiling Point: | 411.9±33.0 °C(Predicted) |
PSA: | 54.98000 |
LogP: | 2.57200 |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
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With pyridine; trichlorophosphate 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h; Yield given. Multistep reaction; |
2-propyl-1H-imidazole-4,5-dicarboxylic acid
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / HCl / Ambient temperature 2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 3: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h View Scheme |
2-propylimidazole-4,5-dicarbonitrile
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 4: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h View Scheme |
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
ethyl 4-isopropyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol for 3h; Ambient temperature; | 93% |
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
A
3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
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With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction. Yields of byproduct given; |
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
B
5-Isopropenyl-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction. Yields of byproduct given; |
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: 82 percent / HCl / dioxane / 16 h / Ambient temperature 4: 100 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 92 percent / HCl / dioxane / 16 h / Ambient temperature 3: 94 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: 82 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |