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159811-51-5

Basic Information
CAS No.: 159811-51-5
Name: Ulipristal
Article Data: 11
Molecular Structure:
Molecular Structure of 159811-51-5 (Ulipristal)
Formula: C28H35 N O3
Molecular Weight: 433.591
Synonyms: CDB3236; Deacetyl CDB 2914; Ulipristal
Density: 1.20
Melting Point: 183.5-184.5oC /Losartan/
Boiling Point: 638.5±55.0 °C(Predicted)
PSA: 57.61000
LogP: 4.97220
Synthetic route

C31H43NO4

159811-51-5

CDB-3236

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20℃; for 1h; Industrial scale;98.2%
126690-41-3

3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene

159811-51-5

CDB-3236

Conditions
ConditionsYield
With sulfuric acid In ethanol for 1h; Heating;88%
Stage #1: 3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene With potassium hydrogensulfate; water at 5℃; for 4h;
Stage #2: With potassium hydroxide; water In dichloromethane Product distribution / selectivity;
With hydrogenchloride; water at 25℃; for 2h;
With hydrogenchloride In water at 25℃; for 2h;

11β-(4-N,N-dimethylaminophenyl)-17α-hydroxy-20-methoxy-19-norpregna-4,9,20-triene-3-one

159811-51-5

CDB-3236

Conditions
ConditionsYield
With acetic acid In water at 25℃; for 1h;74%
With hydrogenchloride In methanol at 20℃; for 0.5h;70%
1094602-02-4

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile

917-54-4

methyllithium

159811-51-5

CDB-3236

Conditions
ConditionsYield
Stage #1: 11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; methyllithium With N,N,N,N,-tetramethylethylenediamine at -50 - -35℃; for 3h;
Stage #2: With water at 20℃;
Stage #3: With sulfuric acid In methanol at 40℃; for 3h;
70.7%
91934-94-0

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile

917-54-4

methyllithium

159811-51-5

CDB-3236

Conditions
ConditionsYield
Stage #1: 11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; methyllithium With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -50 - -40℃; for 3h;
Stage #2: With water In tetrahydrofuran at 20℃;
Stage #3: With sulfuric acid In methanol at 40℃; for 3h;
70%
54201-84-2

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)

159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C
2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
3.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
2.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
2.2: 2 h / 10 - 20 °C / Large scale
3.1: hydrogenchloride / 2 h / 25 °C
View Scheme
54201-83-1

5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal)

159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
1.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
2.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
1.2: 2 h / 10 - 20 °C / Large scale
2.1: hydrogenchloride / 2 h / 25 °C
View Scheme

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 98 percent / DMAP; TEA / tetrahydrofuran / 20 °C
2.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C
2.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C
3.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C
4.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
4.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
5.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
290825-36-4

3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene

159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C
1.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C
2.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C
3.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
3.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
4.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
137532-55-9

3-(ethylenedioxy)estra-5α,10α-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene

159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: triethylamine; acetic acid / Inert atmosphere
3.1: sodium methylate / methanol
4.1: Acidic conditions
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
4.2: 2 h / 70 °C / Inert atmosphere
5.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium / tetrahydrofuran; ethylene dibromide / 3 h / 45 °C / Industrial scale
1.2: 0 °C / Industrial scale
2.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale
2.2: 2 h / -5 - 0 °C / Industrial scale
3.1: methanol / 2.5 h / 70 °C / Industrial scale
3.2: 5 h / 70 °C / Industrial scale
4.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale
View Scheme
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    Ulipristal

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    Reliable Quality Ulipristal

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    Address:No.2-812, Zhongyin Plaza,Yunlong District

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  • Ulipristal

  • Casno:

    159811-51-5

    Ulipristal

    Min.Order: 1 Gram

    FOB Price:  USD $ 66.0-66.0

    Ulipristal Chemical Properties Boiling point 638.5±55.0 °C(Predicted) density 1.20 storage temp. Sealed in dry,Room Temperature pka 12.94±0.60(Predicted)

    SHANGHAI MINSTAR CHEMICAL CO., LTD. is a leading, experienced, professional supplier of API & intermediates, plant extract, food additive, fine chemicals and industry chemicals, et

  •  Shanghai Minstar Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-21-18019205509

    Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA

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  • Ulipristal

  • Casno:

    159811-51-5

    Ulipristal

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 2.0-2.0

    Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

    Welcome to Taizhou Zhenyu Biotech Co.,LTD , Sister Company of Ningbo Zhenlei Chemical co.,ltd ,is a rapid growing company , We are one of TOP supplier and manufactuer of Human APIs

  •  TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:13958565781

    Address:Room 623 Yulan Square Bussiness Building . Jiaojiang Taizhou Zhejiang 318000 China

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  • Ulipristal

  • Casno:

    159811-51-5

    Ulipristal

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, s

  •  Shandong Mopai Biotechnology Co., LTD

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-15965530500

    Address:shandong

       Inquiry Now

  • Ulipristal

  • Casno:

    159811-51-5

    Ulipristal

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.5-1.5

    1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

    KAISA GROUP INC.is the enterprise which is specialize in manfacturing and exporting avariety of Chemical in China. We have the strong economic base and comprehensive technology.We

  •  KAISA GROUP INC

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:15131197030

    Address:1312 17th Street Suite 1402 Denver CO 80202

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  • Ulipristal

  • Casno:

    159811-51-5

    Ulipristal

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.0-1.0

    We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

    We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production in China for chemicals cus

  •  Bluecrystal chem-union

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-1895157

    Address:Liang Xi Qu

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  • 19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

  • Casno:

    159811-51-5

    19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

    Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in carbomer, Dibenzylamine,meglumine,lead acetate and other chemical raw materials and chemical reagents research

  •  Hebei Mojin Biotechnology Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:13231137666

    Address:room 1401,A building,Enjoy city,shijiazhuang city,hebei province,China

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  • 11β-[4-(N,N-dimethylamino)-phenyl]-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione

  • Casno:

    159811-51-5

    11β-[4-(N,N-dimethylamino)-phenyl]-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    highest purity most favorable priceAppearance:solid or liquid Storage:room temperature under 25℃ Package:drum or bag Application:for pharmaceutical Transportation:by sea and air

    Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries. Annually, mo

  •  Kono Chem Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-29-86107037-8015

    Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China

       Inquiry Now

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