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1625-39-4

Basic Information
CAS No.: 1625-39-4
Name: 11-beta,17-alpha,21-trihydroxy-6-alpha-methylpregn-4-ene-3,20-dione
Molecular Structure:
Molecular Structure of 1625-39-4 (11-beta,17-alpha,21-trihydroxy-6-alpha-methylpregn-4-ene-3,20-dione)
Formula: C22H32 O5
Molecular Weight: 376.493
Synonyms: Corticosterone,17-hydroxy-6a-methyl-(6CI); Pregn-4-ene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl- (7CI,8CI); 6a-Methyl-11b,17a,21-trihydroxy-4-pregnene-3,20-dione;6a-Methylcortisol; 6a-Methylhydrocortisone; NSC 19618;U 7240
Density: 1.26g/cm3
Melting Point: 203-208 °C
Boiling Point: 568.2°Cat760mmHg
Flash Point: 311.5°C
PSA: 94.83000
LogP: 2.02760
Synthetic route
76338-56-2

5,11β,17,21-tetrahydroxy-6β-methyl-5α-pregnane-3,20-dione

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
With sodium hydroxide
1625-11-2

21-acetoxy-11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Hydrolysis;
3386-05-8, 14423-18-8, 75110-33-7

21-acetoxy-11β-hydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diacetoxy-phenyl-iodan; OsO4; pyridine / Reagens 4: tert-Butylalkohol
2: Hydrolysis
View Scheme
6726-27-8

3,3;20,20-bis-ethanediyldioxy-6β-methyl-5α-pregnane-5,11β,17,21-tetraol

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous H2SO4; methanol
2: aqueous methanol.NaOH
View Scheme
76338-55-1

3,3;20,20-bis-ethanediyldioxy-5,6α-epoxy-5α-pregnane-11β,17,21-triol

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diethyl ether; tetrahydrofuran
2: aqueous H2SO4; methanol
3: aqueous methanol.NaOH
View Scheme
83-43-2

Methylprednisolone

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
With hydrogen; Wilkinson's catalyst In ethanol; ethyl acetate at 20℃; under 760.051 Torr; for 168h;
With hydrogen; Wilkinson's catalyst In ethanol; ethyl acetate at 20℃; under 760.051 Torr; for 168h;
With hydrogen; Wilkinson's catalyst In ethanol; ethyl acetate at 20℃; under 760.051 Torr; for 168h;
1882-82-2

17-hydroxy-pregn-4-ene-3,11,20-trione

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: toluene-4-sulfonic acid / dichloromethane; water
2: N-methylaniline; hydrogenchloride / tetrahydrofuran
3: hydrogenchloride; palladium on activated charcoal / ethanol; cyclohexene
4: toluene-4-sulfonic acid / dichloromethane
5: sodium tetrahydroborate / methanol
6: hydrogenchloride
7: iodine; calcium chloride; calcium oxide / methanol
8: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide
View Scheme

C22H28O4

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: hydrogenchloride; palladium on activated charcoal / ethanol; cyclohexene
2: toluene-4-sulfonic acid / dichloromethane
3: sodium tetrahydroborate / methanol
4: hydrogenchloride
5: iodine; calcium chloride; calcium oxide / methanol
6: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide
View Scheme
82332-00-1

11-oxomedroxyprogesterone

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / dichloromethane
2: sodium tetrahydroborate / methanol
3: hydrogenchloride
4: iodine; calcium chloride; calcium oxide / methanol
5: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide
View Scheme

C26H38O6

1625-39-4

11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol
2: hydrogenchloride
3: iodine; calcium chloride; calcium oxide / methanol
4: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide
View Scheme
Downstream Products
1625-11-2
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