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CAS No.: | 1625-39-4 |
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Name: | 11-beta,17-alpha,21-trihydroxy-6-alpha-methylpregn-4-ene-3,20-dione |
Molecular Structure: | |
Formula: | C22H32 O5 |
Molecular Weight: | 376.493 |
Synonyms: | Corticosterone,17-hydroxy-6a-methyl-(6CI); Pregn-4-ene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl- (7CI,8CI); 6a-Methyl-11b,17a,21-trihydroxy-4-pregnene-3,20-dione;6a-Methylcortisol; 6a-Methylhydrocortisone; NSC 19618;U 7240 |
Density: | 1.26g/cm3 |
Melting Point: | 203-208 °C |
Boiling Point: | 568.2°Cat760mmHg |
Flash Point: | 311.5°C |
PSA: | 94.83000 |
LogP: | 2.02760 |
5,11β,17,21-tetrahydroxy-6β-methyl-5α-pregnane-3,20-dione
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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With sodium hydroxide |
21-acetoxy-11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Hydrolysis; |
21-acetoxy-11β-hydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 2 steps 1: diacetoxy-phenyl-iodan; OsO4; pyridine / Reagens 4: tert-Butylalkohol 2: Hydrolysis View Scheme |
3,3;20,20-bis-ethanediyldioxy-6β-methyl-5α-pregnane-5,11β,17,21-tetraol
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 2 steps 1: aqueous H2SO4; methanol 2: aqueous methanol.NaOH View Scheme |
3,3;20,20-bis-ethanediyldioxy-5,6α-epoxy-5α-pregnane-11β,17,21-triol
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 3 steps 1: diethyl ether; tetrahydrofuran 2: aqueous H2SO4; methanol 3: aqueous methanol.NaOH View Scheme |
Conditions | Yield |
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With hydrogen; Wilkinson's catalyst In ethanol; ethyl acetate at 20℃; under 760.051 Torr; for 168h; | |
With hydrogen; Wilkinson's catalyst In ethanol; ethyl acetate at 20℃; under 760.051 Torr; for 168h; | |
With hydrogen; Wilkinson's catalyst In ethanol; ethyl acetate at 20℃; under 760.051 Torr; for 168h; |
17-hydroxy-pregn-4-ene-3,11,20-trione
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 8 steps 1: toluene-4-sulfonic acid / dichloromethane; water 2: N-methylaniline; hydrogenchloride / tetrahydrofuran 3: hydrogenchloride; palladium on activated charcoal / ethanol; cyclohexene 4: toluene-4-sulfonic acid / dichloromethane 5: sodium tetrahydroborate / methanol 6: hydrogenchloride 7: iodine; calcium chloride; calcium oxide / methanol 8: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide View Scheme |
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 6 steps 1: hydrogenchloride; palladium on activated charcoal / ethanol; cyclohexene 2: toluene-4-sulfonic acid / dichloromethane 3: sodium tetrahydroborate / methanol 4: hydrogenchloride 5: iodine; calcium chloride; calcium oxide / methanol 6: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide View Scheme |
11-oxomedroxyprogesterone
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / dichloromethane 2: sodium tetrahydroborate / methanol 3: hydrogenchloride 4: iodine; calcium chloride; calcium oxide / methanol 5: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide View Scheme |
11β,17α,21-trihydroxy-6α-methylpregna-4-ene-3,20-dione
Conditions | Yield |
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Multi-step reaction with 4 steps 1: sodium tetrahydroborate / methanol 2: hydrogenchloride 3: iodine; calcium chloride; calcium oxide / methanol 4: sodium hydroxide; potassium acetate / methanol; N,N-dimethyl-formamide View Scheme |